fix+feat: 修 17 号图中文乱码（图内改英文+nan 显示 n.d.）；新增 MitoCarta3.0 结构化提取（script/18 -> ref/mitocarta3.0/）与 P2 预研文档
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# P2 预研：MitoCarta3.0 结构化资产 + liana+ 复用要点
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> 日期：2026-09-17 | 状态：预研完成，待 P2 执行
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> P2 聚焦两方向：**MitoCarta 线粒体通路精细分析** + **liana+ 细胞通讯**
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---
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## 1. MitoCarta3.0 结构化资产（已提取，`script/18_mitocarta_extract.py`）
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`ref/Mouse.MitoCarta3.0.xls`（Rath et al. 2021, NAR）→ `ref/mitocarta3.0/`：
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| 文件 | 内容 |
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|---|---|
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| `Mouse_MitoCarta3.0_genes.csv` | 1140 个小鼠线粒体基因：亚线粒体定位（Matrix 528 / MIM 354 / MOM 110 / IMS 52）、通路归属、证据 |
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| `MitoPathways.csv` | 149 条 MitoPathway，层级拆为 L1/L2/L3 |
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| `MitoPathways_long.csv` | 基因 × 通路长表（3894 行，1037 基因） |
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| `MitoPathways.gmt` | 全层级 GMT → gseapy prerank 直接可用 |
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| `MitoPathways_L1.gmt` | 7 个一级大类 GMT → 模块打分 |
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**L1 七大类**：Metabolism（72 子通路/1659 基因次）、Mitochondrial central dogma（21/787）、OXPHOS（20/672）、Mitochondrial dynamics and surveillance（11/238）、Protein import/sorting/homeostasis（13/275）、Signaling（7/108）、Small molecule transport（5/155）。
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### P2 中用法（对现有分析的增量）
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1. **GSEA prerank 补 Hallmark 盲区**：Hallmark 只有 OXPHOS 一条线粒体通路；用 `MitoPathways.gmt` 对已有 `de_*.csv` 重跑 prerank，可分辨 Complex I–V 各复合体、mtDNA maintenance、mito-ribosome、Fe-S cluster、线粒体动力学（融合/分裂，OPA1 本体所在）等精细通路的方向。
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2. **与手工基因集交叉核对**：P0/P1 的 ETC/CI/糖酵解模块是手工整理，用 MitoCarta L2（如 `OXPHOS > Complex I`）重打分做敏感性核对——若结论一致，正面回应"基因集选择偏倚"质疑。
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3. **OPA1 通路定位**：OPA1 属 `Mitochondrial dynamics and surveillance`，检查该大类在 RGC2-like 的整体方向（预期受扰），及线粒体自噬条目与作者 fig. S5 的对照。
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⚠️ 注意：`ref/` 目录原约定只读，本次按用户明确指示将结构化产物存回 `ref/mitocarta3.0/`（原始 xls 未动），后续同类资产沿用此例。
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---
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## 2. liana+ 复用要点（来自 `D:\个人文档\PROJECTS\mg_liana+`）
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该仓库是用户此前课题（microglia Opa1-cko → neuron，LIANA+ 0.1.9 全流程），以下直接复用：
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### 2.1 关键兼容性补丁（必须照抄，否则 scipy 1.17/numpy 2.x 下直接报错）
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```python
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import liana.method._liana_pipe as _lp
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def _patched_trimean(a, axis=0):
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arr = a.toarray() if hasattr(a, "toarray") else a.A
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return np.mean(np.quantile(arr, q=[0.25, 0.5, 0.5, 0.75], axis=axis), axis=axis)
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_lp._trimean = _patched_trimean
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import liana.method.sc._cellchat as _cc
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_cc.np.product = np.prod # numpy 2.x 移除了 np.product
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# Windows 控制台 UTF-8
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sys.stdout.reconfigure(encoding="utf-8"); sys.stderr.reconfigure(encoding="utf-8")
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```
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### 2.2 核心调用
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```python
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li.mt.rank_aggregate(adata, groupby="cell_type", resource_name="mouseconsensus",
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expr_prop=0.1, min_cells=5, n_perms=...)
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li.pl.dotplot(liana_res=..., source_groups=..., target_groups=...)
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```
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- 资源优先 `mouseconsensus`（内置小鼠 LR 库）；不足时用 `li.rs.get_hcop_orthologs()` 映射 human consensus。
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- 差异通讯的务实策略：**各条件分别跑 rank_aggregate → 比较 Δmagnitude_rank / Δlr_means**（mg_liana+ 的 script/03 即此路线；`li.multi.df_to_lr` 需 liana≥0.2.0，本环境 0.1.9 不可用，不依赖）。
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- 参考文档已就位：`mg_liana+/ref/`（api.md、Steady-state LR、Prior Knowledge、CCC best practices）。
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### 2.3 迁移到本项目的设计调整
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| mg_liana+ 做法 | 本项目调整 | 原因 |
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|---|---|---|
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| cko vs flox 两条件 | **WT / S1 / S2 三条件分别跑** | 沿用方向一致性框架：S1∩S2 方向一致且 S1-S2 不"差异"的 LR 对才可信 |
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| min_cells=5 | microglia WT 仅 8 核、RGC2-like WT 仅 7 核 → 这两类的 WT 侧 LR 近乎不可用，**结论限于方向性**，与第三轮裁决一致 | 小样本硬约束 |
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| expr_prop=0.1 | ⚠️ **深度混杂直接污染 lr_means**（WT 非杆核深度 2 倍），Δlr_means 解释须谨慎，优先看 rank 相对变化而非绝对值 | P1 已证深度是主 confounder |
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| 分组用 cell_type | 分组用 `cmp_group`（Müller / RGC1-like / RGC2-like / Microglia / 其余细胞类型） | 与 P1 分组口径一致 |
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| 聚焦 MG→Neuron | 聚焦 **Müller ↔ Microglia ↔ RGC** 三角 + 候选轴：C3–C3aR、Apoe–Trem2、Spp1–CD44/Itg 家族、补体级联；另可加 Müller→RGC 代谢支持轴（Glul/Slc1a3 谷氨酸循环） | AGENTS.md 假设（b）线粒体损伤→炎症→神经元 |
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### 2.4 复用文件清单
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- `script/02_steady_state_lr.py` → 改造为本项目 `script/19_liana_steady_state.py`（补丁 + 三条件循环）
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- `script/03_differential_ccc.py` → 改造为 `script/20_liana_diff.py`（三向比较 + 一致性过滤）
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- dotplot/tileplot 可视化模式参考其 `05/06/07` 脚本（plotnine）
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---
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## 3. P2 建议执行顺序
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1. `script/19` MitoCarta GSEA prerank（复用 de_*.csv，纯增量，半天内）
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2. `script/20` MitoCarta L2 模块敏感性核对（对照手工 ETC/CI 列表）
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3. `script/21` liana 三条件稳态 LR（先 3000 核采样跑通，再全量）
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4. `script/22` liana 差异通讯 + 一致性过滤 + 候选轴可视化
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5. 汇总进 `doc/第一轮分析报告_P2.md`
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MitoPathway,MitoPathway Hierarchy,Genes,n_genes,L1,L2,L3
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Mitochondrial central dogma,Mitochondrial central dogma,"2810006K23Rik, Aars2, Alkbh1, Angel2, Apex1, Atad3a, Aurkaip1, Cars2, Cdk5rap1, Chchd1, Coa3, Cox14, Dap3, Dars2, Ddx28, Dhx30, Dna2, Dus2, Ears2, Elac2, Endog, Eral1, Exd2, Exog, Fars2, Fastk, Fastkd1, Fastkd2, Fastkd3, Fastkd5, Gadd45gip1, Gars, Gatb, Gatc, Gfm1, Gfm2, Grsf1, Gtpbp10, Gtpbp3, Guf1, Hars2, Hemk1, Hsd17b10, Iars2, Kars, Lactb2, Lars2, Lig3, Lrpprc, Malsu1, Mars2, Metap1d, Mettl15, Mettl17, Mettl4, Mettl5, Mettl8, Mgme1, Mief1, Mpv17l2, Mrm1, Mrm2, Mrm3, Mrpl1, Mrpl10, Mrpl11, Mrpl12, Mrpl13, Mrpl14, Mrpl15, Mrpl16, Mrpl17, Mrpl18, Mrpl19, Mrpl2, Mrpl20, Mrpl21, Mrpl22, Mrpl23, Mrpl24, Mrpl27, Mrpl28, Mrpl3, Mrpl30, Mrpl32, Mrpl33, Mrpl34, Mrpl35, Mrpl36, Mrpl37, Mrpl38, Mrpl39, Mrpl4, Mrpl40, Mrpl41, Mrpl42, Mrpl43, Mrpl44, Mrpl45, Mrpl46, Mrpl47, Mrpl48, Mrpl49, Mrpl50, Mrpl51, Mrpl52, Mrpl53, Mrpl54, Mrpl55, Mrpl57, Mrpl58, Mrpl9, Mrps10, Mrps11, Mrps12, Mrps14, Mrps15, Mrps16, Mrps17, Mrps18a, Mrps18b, Mrps18c, Mrps2, Mrps21, Mrps22, Mrps23, Mrps24, Mrps25, Mrps26, Mrps27, Mrps28, Mrps30, Mrps31, Mrps33, Mrps34, Mrps35, Mrps36, Mrps5, Mrps6, Mrps7, Mrps9, Mrrf, Mterf1a, Mterf1b, Mterf2, Mterf3, Mterf4, Mtfmt, Mtg1, Mtg2, Mtif2, Mtif3, Mto1, Mtpap, Mtres1, Mtrf1, Mtrf1l, Mutyh, Myg1, Nars2, Ngrn, Noa1, Nsun2, Nsun3, Nsun4, Ogg1, Osgepl1, Oxa1l, Pars2, Pde12, Pdf, Pif1, Pnpt1, Polb, Poldip2, Polg, Polg2, Polq, Polrmt, Ppa2, Primpol, Prorp, Ptcd1, Ptcd2, Ptcd3, Pus1, Pusl1, Qrsl1, Qtrt1, Rars2, Rbfa, Rcc1l, Recql4, Rexo2, Rmnd1, Rnaseh1, Rpusd3, Rpusd4, Sars2, Slirp, Ssbp1, Supv3l1, Taco1, Tars2, Tbrg4, Tefm, Tfam, Tfb1m, Tfb2m, Thg1l, Timm21, Top1mt, Top3a, Trit1, Trmt1, Trmt10c, Trmt2b, Trmt5, Trmu, Trnt1, Trub2, Tsfm, Tufm, Twnk, Ung, Vars2, Wars2, Yars2, Ybey, Yrdc",230,Mitochondrial central dogma,,
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mtDNA maintenance,Mitochondrial central dogma > mtDNA maintenance,"Apex1, Atad3a, Dna2, Endog, Exog, Lig3, Mettl4, Mgme1, Mterf1a, Mterf1b, Mterf2, Mutyh, Ogg1, Pif1, Polb, Poldip2, Polg, Polg2, Polq, Polrmt, Ppa2, Primpol, Recql4, Rnaseh1, Ssbp1, Tfam, Tfb2m, Top1mt, Top3a, Twnk, Ung",31,Mitochondrial central dogma,mtDNA maintenance,
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mtDNA replication,Mitochondrial central dogma > mtDNA maintenance > mtDNA replication,"Dna2, Exog, Lig3, Mgme1, Polg, Polg2, Polrmt, Rnaseh1, Ssbp1, Tfam, Tfb2m, Top1mt, Top3a, Twnk",14,Mitochondrial central dogma,mtDNA maintenance,mtDNA replication
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mtDNA nucleoid,Mitochondrial central dogma > mtDNA maintenance > mtDNA nucleoid,"Atad3a, Mterf1a, Mterf1b, Mterf2, Poldip2, Polg, Polg2, Polrmt, Ssbp1, Tfam, Twnk",11,Mitochondrial central dogma,mtDNA maintenance,mtDNA nucleoid
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mtDNA repair,Mitochondrial central dogma > mtDNA maintenance > mtDNA repair,"Apex1, Exog, Lig3, Ogg1, Polb, Polg, Primpol, Recql4, Ung",9,Mitochondrial central dogma,mtDNA maintenance,mtDNA repair
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mtDNA modifications,Mitochondrial central dogma > mtDNA maintenance > mtDNA modifications,Mettl4,1,Mitochondrial central dogma,mtDNA maintenance,mtDNA modifications
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mtDNA stability and decay,Mitochondrial central dogma > mtDNA maintenance > mtDNA stability and decay,"Endog, Exog, Mgme1",3,Mitochondrial central dogma,mtDNA maintenance,mtDNA stability and decay
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mtRNA metabolism,Mitochondrial central dogma > mtRNA metabolism,"Alkbh1, Angel2, Cdk5rap1, Ddx28, Dhx30, Dus2, Elac2, Endog, Eral1, Fastk, Fastkd1, Fastkd2, Fastkd3, Fastkd5, Grsf1, Gtpbp3, Hsd17b10, Lactb2, Lrpprc, Mettl15, Mettl17, Mettl5, Mettl8, Mrm1, Mrm2, Mrm3, Mrpl12, Mrpl47, Mrps7, Mrps9, Mterf1a, Mterf1b, Mto1, Mtpap, Mtres1, Myg1, Ngrn, Noa1, Nsun2, Nsun3, Nsun4, Osgepl1, Pde12, Pnpt1, Polrmt, Ppa2, Prorp, Ptcd1, Ptcd2, Pus1, Qtrt1, Rcc1l, Rexo2, Rmnd1, Rnaseh1, Rpusd3, Rpusd4, Slirp, Supv3l1, Tbrg4, Tefm, Tfam, Tfb1m, Tfb2m, Thg1l, Top1mt, Trit1, Trmt1, Trmt10c, Trmt2b, Trmt5, Trmu, Trnt1, Trub2, Ybey, Yrdc",76,Mitochondrial central dogma,mtRNA metabolism,
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Transcription,Mitochondrial central dogma > mtRNA metabolism > Transcription,"Mrpl12, Mterf1a, Mterf1b, Mtres1, Polrmt, Tefm, Tfam, Tfb2m, Top1mt",9,Mitochondrial central dogma,mtRNA metabolism,Transcription
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mtRNA granules,Mitochondrial central dogma > mtRNA metabolism > mtRNA granules,"Alkbh1, Ddx28, Dhx30, Eral1, Fastk, Fastkd1, Fastkd2, Fastkd5, Grsf1, Hsd17b10, Mrm1, Mrm2, Mrpl47, Mrps7, Mrps9, Mtpap, Noa1, Prorp, Ptcd1, Ptcd2, Pus1, Rmnd1, Rpusd3, Rpusd4, Supv3l1, Tfb1m, Trmt10c, Trub2",28,Mitochondrial central dogma,mtRNA metabolism,mtRNA granules
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Polycistronic mtRNA processing,Mitochondrial central dogma > mtRNA metabolism > Polycistronic mtRNA processing,"Elac2, Fastk, Fastkd1, Fastkd2, Fastkd3, Fastkd5, Grsf1, Hsd17b10, Prorp, Ptcd2, Tbrg4, Trmt10c, Ybey",13,Mitochondrial central dogma,mtRNA metabolism,Polycistronic mtRNA processing
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mt-tRNA modifications,Mitochondrial central dogma > mtRNA metabolism > mt-tRNA modifications,"Alkbh1, Cdk5rap1, Dus2, Gtpbp3, Hsd17b10, Mto1, Nsun2, Nsun3, Osgepl1, Pus1, Qtrt1, Rpusd4, Thg1l, Trit1, Trmt1, Trmt10c, Trmt2b, Trmt5, Trmu, Trnt1, Yrdc",21,Mitochondrial central dogma,mtRNA metabolism,mt-tRNA modifications
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mt-rRNA modifications,Mitochondrial central dogma > mtRNA metabolism > mt-rRNA modifications,"Mettl15, Mettl17, Mettl5, Mrm1, Mrm2, Mrm3, Mtpap, Myg1, Ngrn, Nsun4, Rcc1l, Rpusd3, Rpusd4, Tfb1m, Trit1, Trmt2b, Trub2",17,Mitochondrial central dogma,mtRNA metabolism,mt-rRNA modifications
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mt-mRNA modifications,Mitochondrial central dogma > mtRNA metabolism > mt-mRNA modifications,"Angel2, Mtpap, Myg1, Pde12",4,Mitochondrial central dogma,mtRNA metabolism,mt-mRNA modifications
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mtRNA stability and decay,Mitochondrial central dogma > mtRNA metabolism > mtRNA stability and decay,"Endog, Fastk, Fastkd1, Fastkd2, Fastkd3, Fastkd5, Grsf1, Lactb2, Lrpprc, Mtpap, Pde12, Pnpt1, Rexo2, Rnaseh1, Slirp, Supv3l1, Tbrg4",17,Mitochondrial central dogma,mtRNA metabolism,mtRNA stability and decay
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Translation,Mitochondrial central dogma > Translation,"2810006K23Rik, Aars2, Aurkaip1, Cars2, Chchd1, Coa3, Cox14, Dap3, Dars2, Ddx28, Dhx30, Ears2, Eral1, Exd2, Fars2, Fastkd2, Gadd45gip1, Gars, Gatb, Gatc, Gfm1, Gfm2, Grsf1, Gtpbp10, Guf1, Hars2, Hemk1, Iars2, Kars, Lars2, Lrpprc, Malsu1, Mars2, Metap1d, Mettl17, Mief1, Mpv17l2, Mrm2, Mrm3, Mrpl1, Mrpl10, Mrpl11, Mrpl12, Mrpl13, Mrpl14, Mrpl15, Mrpl16, Mrpl17, Mrpl18, Mrpl19, Mrpl2, Mrpl20, Mrpl21, Mrpl22, Mrpl23, Mrpl24, Mrpl27, Mrpl28, Mrpl3, Mrpl30, Mrpl32, Mrpl33, Mrpl34, Mrpl35, Mrpl36, Mrpl37, Mrpl38, Mrpl39, Mrpl4, Mrpl40, Mrpl41, Mrpl42, Mrpl43, Mrpl44, Mrpl45, Mrpl46, Mrpl47, Mrpl48, Mrpl49, Mrpl50, Mrpl51, Mrpl52, Mrpl53, Mrpl54, Mrpl55, Mrpl57, Mrpl58, Mrpl9, Mrps10, Mrps11, Mrps12, Mrps14, Mrps15, Mrps16, Mrps17, Mrps18a, Mrps18b, Mrps18c, Mrps2, Mrps21, Mrps22, Mrps23, Mrps24, Mrps25, Mrps26, Mrps27, Mrps28, Mrps30, Mrps31, Mrps33, Mrps34, Mrps35, Mrps36, Mrps5, Mrps6, Mrps7, Mrps9, Mrrf, Mterf1a, Mterf3, Mterf4, Mtfmt, Mtg1, Mtg2, Mtif2, Mtif3, Mtres1, Mtrf1, Mtrf1l, Nars2, Ngrn, Noa1, Nsun4, Oxa1l, Pars2, Pdf, Ppa2, Ptcd3, Pusl1, Qrsl1, Rars2, Rbfa, Rmnd1, Sars2, Slirp, Taco1, Tars2, Tfb1m, Timm21, Tsfm, Tufm, Vars2, Wars2, Yars2, Ybey",155,Mitochondrial central dogma,Translation,
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Mitochondrial ribosome,Mitochondrial central dogma > Translation > Mitochondrial ribosome,"Aurkaip1, Chchd1, Dap3, Gadd45gip1, Mrpl1, Mrpl10, Mrpl11, Mrpl12, Mrpl13, Mrpl14, Mrpl15, Mrpl16, Mrpl17, Mrpl18, Mrpl19, Mrpl2, Mrpl20, Mrpl21, Mrpl22, Mrpl23, Mrpl24, Mrpl27, Mrpl28, Mrpl3, Mrpl30, Mrpl32, Mrpl33, Mrpl34, Mrpl35, Mrpl36, Mrpl37, Mrpl38, Mrpl39, Mrpl4, Mrpl40, Mrpl41, Mrpl42, Mrpl43, Mrpl44, Mrpl45, Mrpl46, Mrpl47, Mrpl48, Mrpl49, Mrpl50, Mrpl51, Mrpl52, Mrpl53, Mrpl54, Mrpl55, Mrpl57, Mrpl58, Mrpl9, Mrps10, Mrps11, Mrps12, Mrps14, Mrps15, Mrps16, Mrps17, Mrps18a, Mrps18b, Mrps18c, Mrps2, Mrps21, Mrps22, Mrps23, Mrps24, Mrps25, Mrps26, Mrps27, Mrps28, Mrps30, Mrps31, Mrps33, Mrps34, Mrps35, Mrps36, Mrps5, Mrps6, Mrps7, Mrps9, Ptcd3",83,Mitochondrial central dogma,Translation,Mitochondrial ribosome
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Mitochondrial ribosome assembly,Mitochondrial central dogma > Translation > Mitochondrial ribosome assembly,"Ddx28, Dhx30, Eral1, Fastkd2, Grsf1, Gtpbp10, Malsu1, Mettl17, Mief1, Mpv17l2, Mrm2, Mrm3, Mterf1a, Mterf3, Mterf4, Mtg1, Mtg2, Ngrn, Noa1, Nsun4, Ptcd3, Rbfa, Tfb1m, Ybey",24,Mitochondrial central dogma,Translation,Mitochondrial ribosome assembly
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Translation factors,Mitochondrial central dogma > Translation > Translation factors,"2810006K23Rik, Coa3, Cox14, Gfm1, Gfm2, Hemk1, Mrpl58, Mrrf, Mtif2, Mtif3, Mtrf1, Mtrf1l, Taco1, Timm21, Tsfm, Tufm",16,Mitochondrial central dogma,Translation,Translation factors
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mt-tRNA synthetases,Mitochondrial central dogma > Translation > mt-tRNA synthetases,"Aars2, Cars2, Dars2, Ears2, Fars2, Gars, Gatb, Gatc, Hars2, Iars2, Kars, Lars2, Mars2, Nars2, Pars2, Qrsl1, Rars2, Sars2, Tars2, Vars2, Wars2, Yars2",22,Mitochondrial central dogma,Translation,mt-tRNA synthetases
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fMet processing,Mitochondrial central dogma > Translation > fMet processing,"Metap1d, Mtfmt, Pdf",3,Mitochondrial central dogma,Translation,fMet processing
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"Protein import, sorting and homeostasis","Protein import, sorting and homeostasis","Afg1l, Afg3l1, Afg3l2, Agk, Aifm1, Atad1, Atp23, Casp3, Casp8, Casp9, Chchd4, Clpb, Clpp, Clpx, Dnaja3, Dnajc11, Dnajc15, Dnajc19, Dnajc4, Dnlz, Fkbp10, Gfer, Grpel1, Grpel2, Hspd1, Hspe1, Htra2, Ide, Immp1l, Immp2l, Lactb, Lap3, Lonp1, Maip1, Metap1d, Mipep, Mtx1, Mtx2, Mul1, Nln, Nrd1, Oma1, Oxa1l, Pam16, Park7, Parl, Pdf, Phb, Phb2, Pitrm1, Pmpca, Pmpcb, Prss35, Romo1, Samm50, Spg7, Stoml2, Timm10, Timm10b, Timm13, Timm17a, Timm17b, Timm21, Timm22, Timm23, Timm29, Timm44, Timm50, Timm8a1, Timm8a2, Timm8b, Timm9, Tomm20, Tomm20l, Tomm22, Tomm34, Tomm40, Tomm40l, Tomm5, Tomm6, Tomm7, Tomm70a, Trap1, Uqcrc1, Uqcrc2, Usp30, Xpnpep3, Yme1l1",88,"Protein import, sorting and homeostasis",,
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Protein import and sorting,"Protein import, sorting and homeostasis > Protein import and sorting","Agk, Aifm1, Chchd4, Dnajc11, Dnajc15, Dnajc19, Gfer, Grpel1, Grpel2, Immp1l, Immp2l, Mipep, Mtx1, Mtx2, Nrd1, Oxa1l, Pam16, Pmpca, Pmpcb, Romo1, Samm50, Timm10, Timm10b, Timm13, Timm17a, Timm17b, Timm21, Timm22, Timm23, Timm29, Timm44, Timm50, Timm8a1, Timm8a2, Timm8b, Timm9, Tomm20, Tomm20l, Tomm22, Tomm34, Tomm40, Tomm40l, Tomm5, Tomm6, Tomm7, Tomm70a, Uqcrc1, Uqcrc2, Xpnpep3",49,"Protein import, sorting and homeostasis",Protein import and sorting,
|
||||
TOM,"Protein import, sorting and homeostasis > Protein import and sorting > TOM","Tomm20, Tomm22, Tomm34, Tomm40, Tomm40l, Tomm5, Tomm6, Tomm7, Tomm70a",9,"Protein import, sorting and homeostasis",Protein import and sorting,TOM
|
||||
SAM,"Protein import, sorting and homeostasis > Protein import and sorting > SAM","Mtx1, Mtx2, Samm50",3,"Protein import, sorting and homeostasis",Protein import and sorting,SAM
|
||||
MIA40,"Protein import, sorting and homeostasis > Protein import and sorting > MIA40","Aifm1, Chchd4, Gfer",3,"Protein import, sorting and homeostasis",Protein import and sorting,MIA40
|
||||
TIM22 carrier pathway,"Protein import, sorting and homeostasis > Protein import and sorting > TIM22 carrier pathway","Agk, Timm22, Timm29",3,"Protein import, sorting and homeostasis",Protein import and sorting,TIM22 carrier pathway
|
||||
TIM23 presequence pathway,"Protein import, sorting and homeostasis > Protein import and sorting > TIM23 presequence pathway","Romo1, Timm17a, Timm17b, Timm21, Timm23, Timm50",6,"Protein import, sorting and homeostasis",Protein import and sorting,TIM23 presequence pathway
|
||||
Import motor,"Protein import, sorting and homeostasis > Protein import and sorting > Import motor","Dnajc15, Dnajc19, Grpel1, Grpel2, Pam16, Timm44",6,"Protein import, sorting and homeostasis",Protein import and sorting,Import motor
|
||||
OXA,"Protein import, sorting and homeostasis > Protein import and sorting > OXA",Oxa1l,1,"Protein import, sorting and homeostasis",Protein import and sorting,OXA
|
||||
Preprotein cleavage,"Protein import, sorting and homeostasis > Protein import and sorting > Preprotein cleavage","Immp1l, Immp2l, Mipep, Pmpca, Pmpcb, Uqcrc1, Uqcrc2, Xpnpep3",8,"Protein import, sorting and homeostasis",Protein import and sorting,Preprotein cleavage
|
||||
Protein homeostasis,"Protein import, sorting and homeostasis > Protein homeostasis","Afg1l, Afg3l1, Afg3l2, Atad1, Atp23, Casp3, Casp8, Casp9, Clpb, Clpp, Clpx, Dnaja3, Dnajc4, Dnlz, Fkbp10, Hspd1, Hspe1, Htra2, Ide, Immp1l, Immp2l, Lactb, Lap3, Lonp1, Maip1, Metap1d, Mipep, Mul1, Nln, Nrd1, Oma1, Park7, Parl, Pdf, Phb, Phb2, Pitrm1, Pmpca, Pmpcb, Prss35, Spg7, Stoml2, Timm10, Timm10b, Timm13, Timm8a1, Timm8a2, Timm8b, Timm9, Trap1, Usp30, Xpnpep3, Yme1l1",53,"Protein import, sorting and homeostasis",Protein homeostasis,
|
||||
Proteases,"Protein import, sorting and homeostasis > Protein homeostasis > Proteases","Afg1l, Afg3l1, Afg3l2, Atad1, Atp23, Casp3, Casp9, Clpb, Clpp, Clpx, Htra2, Ide, Immp1l, Immp2l, Lactb, Lap3, Lonp1, Metap1d, Mipep, Nln, Oma1, Parl, Pitrm1, Pmpca, Pmpcb, Spg7, Usp30, Xpnpep3, Yme1l1",29,"Protein import, sorting and homeostasis",Protein homeostasis,Proteases
|
||||
Chaperones,"Protein import, sorting and homeostasis > Protein homeostasis > Chaperones","Dnaja3, Dnlz, Fkbp10, Hspd1, Hspe1, Maip1, Nrd1, Phb, Phb2, Timm10, Timm10b, Timm13, Timm8a1, Timm8a2, Timm8b, Timm9, Trap1",17,"Protein import, sorting and homeostasis",Protein homeostasis,Chaperones
|
||||
OXPHOS,OXPHOS,"Acad9, Aifm1, Atp5a1, Atp5b, Atp5c1, Atp5d, Atp5e, Atp5g1, Atp5g2, Atp5g3, Atp5h, Atp5j, Atp5j2, Atp5k, Atp5l, Atp5md, Atp5mpl, Atp5o, Atp5pb, Atpaf1, Atpaf2, Atpif1, Atpsckmt, Bcs1l, Cep89, Cmc1, Cmc2, Coa3, Coa4, Coa5, Coa6, Coa7, Coa8, Cox10, Cox11, Cox14, Cox15, Cox16, Cox17, Cox18, Cox19, Cox20, Cox4i1, Cox4i2, Cox5a, Cox5b, Cox6a1, Cox6a2, Cox6b1, Cox6b2, Cox6c, Cox7a1, Cox7a2, Cox7a2l, Cox7b, Cox7c, Cox8a, Cox8b, Cox8c, Cyc1, Cycs, Cyct, Dmac1, Dmac2, Dmac2l, Ecsit, Fmc1, Foxred1, Hccs, Higd1a, Higd2a, Lyrm2, Lyrm7, mt-Atp6, mt-Atp8, mt-Co1, mt-Co2, mt-Co3, mt-Cytb, mt-Nd1, mt-Nd2, mt-Nd3, mt-Nd4, mt-Nd4l, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa3, Ndufa4, Ndufa5, Ndufa6, Ndufa7, Ndufa8, Ndufa9, Ndufab1, Ndufaf1, Ndufaf2, Ndufaf3, Ndufaf4, Ndufaf5, Ndufaf6, Ndufaf7, Ndufaf8, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufc2, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3, Nubpl, Pet100, Pet117, Pnkd, Rab5if, Sco1, Sco2, Sdha, Sdhaf1, Sdhaf2, Sdhaf3, Sdhaf4, Sdhb, Sdhc, Sdhd, Smim20, Surf1, Taco1, Timm21, Timmdc1, Tmem126a, Tmem126b, Tmem177, Tmem186, Tmem70, Ttc19, Uqcc1, Uqcc2, Uqcc3, Uqcr10, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrh, Uqcrq",168,OXPHOS,,
|
||||
OXPHOS subunits,OXPHOS > OXPHOS subunits,"Atp5a1, Atp5b, Atp5c1, Atp5d, Atp5e, Atp5g1, Atp5g2, Atp5g3, Atp5h, Atp5j, Atp5j2, Atp5k, Atp5l, Atp5md, Atp5mpl, Atp5o, Atp5pb, Atpif1, Cox4i1, Cox4i2, Cox5a, Cox5b, Cox6a1, Cox6a2, Cox6b1, Cox6b2, Cox6c, Cox7a1, Cox7a2, Cox7a2l, Cox7b, Cox7c, Cox8a, Cox8b, Cox8c, Cyc1, Cycs, Cyct, Dmac2l, Hccs, mt-Atp6, mt-Atp8, mt-Co1, mt-Co2, mt-Co3, mt-Cytb, mt-Nd1, mt-Nd2, mt-Nd3, mt-Nd4, mt-Nd4l, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa3, Ndufa4, Ndufa5, Ndufa6, Ndufa7, Ndufa8, Ndufa9, Ndufab1, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufc2, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3, Sdha, Sdhb, Sdhc, Sdhd, Uqcr10, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrh, Uqcrq",102,OXPHOS,OXPHOS subunits,
|
||||
OXPHOS assembly factors,OXPHOS > OXPHOS assembly factors,"Acad9, Aifm1, Atpaf1, Atpaf2, Atpsckmt, Bcs1l, Cep89, Cmc1, Cmc2, Coa3, Coa4, Coa5, Coa6, Coa7, Coa8, Cox10, Cox11, Cox14, Cox15, Cox16, Cox17, Cox18, Cox19, Cox20, Cox7a2l, Dmac1, Dmac2, Ecsit, Fmc1, Foxred1, Higd1a, Higd2a, Lyrm2, Lyrm7, Ndufaf1, Ndufaf2, Ndufaf3, Ndufaf4, Ndufaf5, Ndufaf6, Ndufaf7, Ndufaf8, Nubpl, Pet100, Pet117, Pnkd, Rab5if, Sco1, Sco2, Sdhaf1, Sdhaf2, Sdhaf3, Sdhaf4, Smim20, Surf1, Taco1, Timm21, Timmdc1, Tmem126a, Tmem126b, Tmem177, Tmem186, Tmem70, Ttc19, Uqcc1, Uqcc2, Uqcc3",67,OXPHOS,OXPHOS assembly factors,
|
||||
Complex I,OXPHOS > Complex I,"Acad9, Aifm1, Dmac1, Dmac2, Ecsit, Foxred1, Lyrm2, mt-Nd1, mt-Nd2, mt-Nd3, mt-Nd4, mt-Nd4l, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa3, Ndufa5, Ndufa6, Ndufa7, Ndufa8, Ndufa9, Ndufab1, Ndufaf1, Ndufaf2, Ndufaf3, Ndufaf4, Ndufaf5, Ndufaf6, Ndufaf7, Ndufaf8, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufc2, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3, Nubpl, Timmdc1, Tmem126a, Tmem126b, Tmem186, Tmem70",64,OXPHOS,Complex I,
|
||||
CI subunits,OXPHOS > Complex I > CI subunits,"mt-Nd1, mt-Nd2, mt-Nd3, mt-Nd4, mt-Nd4l, mt-Nd5, mt-Nd6, Ndufa1, Ndufa10, Ndufa11, Ndufa12, Ndufa13, Ndufa2, Ndufa3, Ndufa5, Ndufa6, Ndufa7, Ndufa8, Ndufa9, Ndufab1, Ndufb10, Ndufb11, Ndufb2, Ndufb3, Ndufb4, Ndufb5, Ndufb6, Ndufb7, Ndufb8, Ndufb9, Ndufc1, Ndufc2, Ndufs1, Ndufs2, Ndufs3, Ndufs4, Ndufs5, Ndufs6, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Ndufv3",43,OXPHOS,Complex I,CI subunits
|
||||
CI assembly factors,OXPHOS > Complex I > CI assembly factors,"Acad9, Aifm1, Dmac1, Dmac2, Ecsit, Foxred1, Lyrm2, Ndufaf1, Ndufaf2, Ndufaf3, Ndufaf4, Ndufaf5, Ndufaf6, Ndufaf7, Ndufaf8, Nubpl, Timmdc1, Tmem126a, Tmem126b, Tmem186, Tmem70",21,OXPHOS,Complex I,CI assembly factors
|
||||
Complex II,OXPHOS > Complex II,"Sdha, Sdhaf1, Sdhaf2, Sdhaf3, Sdhaf4, Sdhb, Sdhc, Sdhd",8,OXPHOS,Complex II,
|
||||
CII subunits,OXPHOS > Complex II > CII subunits,"Sdha, Sdhb, Sdhc, Sdhd",4,OXPHOS,Complex II,CII subunits
|
||||
CII assembly factors,OXPHOS > Complex II > CII assembly factors,"Sdhaf1, Sdhaf2, Sdhaf3, Sdhaf4",4,OXPHOS,Complex II,CII assembly factors
|
||||
Complex III,OXPHOS > Complex III,"Bcs1l, Cyc1, Lyrm7, mt-Cytb, Ttc19, Uqcc1, Uqcc2, Uqcc3, Uqcr10, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrh, Uqcrq",16,OXPHOS,Complex III,
|
||||
CIII subunits,OXPHOS > Complex III > CIII subunits,"Cyc1, mt-Cytb, Uqcr10, Uqcr11, Uqcrb, Uqcrc1, Uqcrc2, Uqcrfs1, Uqcrh, Uqcrq",10,OXPHOS,Complex III,CIII subunits
|
||||
CIII assembly factors,OXPHOS > Complex III > CIII assembly factors,"Bcs1l, Lyrm7, Ttc19, Uqcc1, Uqcc2, Uqcc3",6,OXPHOS,Complex III,CIII assembly factors
|
||||
Complex IV,OXPHOS > Complex IV,"Cep89, Cmc1, Cmc2, Coa3, Coa4, Coa5, Coa6, Coa7, Coa8, Cox10, Cox11, Cox14, Cox15, Cox16, Cox17, Cox18, Cox19, Cox20, Cox4i1, Cox4i2, Cox5a, Cox5b, Cox6a1, Cox6a2, Cox6b1, Cox6b2, Cox6c, Cox7a1, Cox7a2, Cox7a2l, Cox7b, Cox7c, Cox8a, Cox8b, Cox8c, Higd1a, mt-Co1, mt-Co2, mt-Co3, Ndufa4, Pet100, Pet117, Pnkd, Sco1, Sco2, Smim20, Surf1, Taco1, Timm21, Tmem177",50,OXPHOS,Complex IV,
|
||||
CIV subunits,OXPHOS > Complex IV > CIV subunits,"Cox4i1, Cox4i2, Cox5a, Cox5b, Cox6a1, Cox6a2, Cox6b1, Cox6b2, Cox6c, Cox7a1, Cox7a2, Cox7a2l, Cox7b, Cox7c, Cox8a, Cox8b, Cox8c, mt-Co1, mt-Co2, mt-Co3, Ndufa4",21,OXPHOS,Complex IV,CIV subunits
|
||||
CIV assembly factors,OXPHOS > Complex IV > CIV assembly factors,"Cep89, Cmc1, Cmc2, Coa3, Coa4, Coa5, Coa6, Coa7, Coa8, Cox10, Cox11, Cox14, Cox15, Cox16, Cox17, Cox18, Cox19, Cox20, Higd1a, Pet100, Pet117, Pnkd, Sco1, Sco2, Smim20, Surf1, Taco1, Timm21, Tmem177",29,OXPHOS,Complex IV,CIV assembly factors
|
||||
Complex V,OXPHOS > Complex V,"Atp5a1, Atp5b, Atp5c1, Atp5d, Atp5e, Atp5g1, Atp5g2, Atp5g3, Atp5h, Atp5j, Atp5j2, Atp5k, Atp5l, Atp5md, Atp5mpl, Atp5o, Atp5pb, Atpaf1, Atpaf2, Atpif1, Atpsckmt, Dmac2l, Fmc1, mt-Atp6, mt-Atp8, Tmem70",26,OXPHOS,Complex V,
|
||||
CV subunits,OXPHOS > Complex V > CV subunits,"Atp5a1, Atp5b, Atp5c1, Atp5d, Atp5e, Atp5g1, Atp5g2, Atp5g3, Atp5h, Atp5j, Atp5j2, Atp5k, Atp5l, Atp5md, Atp5mpl, Atp5o, Atp5pb, Atpif1, Dmac2l, mt-Atp6, mt-Atp8",21,OXPHOS,Complex V,CV subunits
|
||||
CV assembly factors,OXPHOS > Complex V > CV assembly factors,"Atpaf1, Atpaf2, Atpsckmt, Fmc1, Tmem70",5,OXPHOS,Complex V,CV assembly factors
|
||||
Respirasome assembly,OXPHOS > Respirasome assembly,"Cox7a2l, Higd1a, Higd2a, Rab5if",4,OXPHOS,Respirasome assembly,
|
||||
Cytochrome C,OXPHOS > Cytochrome C,"Cycs, Cyct, Hccs",3,OXPHOS,Cytochrome C,
|
||||
Metabolism,Metabolism,"Aadat, Aass, Abat, Abcb10, Abcb6, Abcb7, Abhd10, Abhd11, Acaa1a, Acaa1b, Acaa2, Acaca, Acacb, Acad10, Acad11, Acad12, Acad8, Acadl, Acadm, Acads, Acadsb, Acadvl, Acat1, Acly, Aco2, Acod1, Acot10, Acot11, Acot13, Acot2, Acot7, Acot9, Acp6, Acsf2, Acsf3, Acsl1, Acsl6, Acsm1, Acsm2, Acsm3, Acsm4, Acsm5, Acss1, Acss3, Adhfe1, Agk, Agmat, Agpat4, Agpat5, Agxt, Agxt2, Aifm2, Aifm3, Ak2, Ak3, Ak4, Akr1b10, Akr1b7, Akr7a5, Alas1, Alas2, Aldh18a1, Aldh1b1, Aldh1l1, Aldh1l2, Aldh2, Aldh3a2, Aldh4a1, Aldh5a1, Aldh6a1, Aldh7a1, Aldh9a1, Amacr, Amt, Antkmt, Arg2, Auh, Bcat2, Bckdha, Bckdhb, Bckdk, Bco2, Bdh1, Bola1, Bola3, Bphl, Car5a, Car5b, Cat, Cbr2, Cbr3, Cbr4, Chchd7, Chdh, Chpt1, Cisd1, Cisd3, Ckmt1, Ckmt2, Clybl, Cmpk2, Coasy, Comt, Coq10a, Coq10b, Coq2, Coq3, Coq4, Coq5, Coq6, Coq7, Coq8a, Coq8b, Coq9, Cox10, Cox11, Cox15, Cox17, Cox19, Cpox, Cps1, Cpt1a, Cpt1b, Cpt1c, Cpt2, Crat, Crls1, Crot, Cs, Cyb5b, Cyb5r3, Cyc1, Cycs, Cyct, Cyp11a1, Cyp11b1, Cyp11b2, Cyp24a1, Cyp27a1, Cyp27b1, D2hgdh, Dbi, Dbt, Dcxr, Decr1, Dglucy, Dguok, Dhodh, Dhrs1, Dhrs2, Dhrs4, Dhtkd1, Dlat, Dld, Dlst, Dmgdh, Dna2, Dut, Ech1, Echdc1, Echs1, Eci1, Eci2, Ehhadh, Ephx2, Etfa, Etfb, Etfbkmt, Etfdh, Etfrf1, Ethe1, Fabp1, Fahd1, Fam210b, Fasn, Fdps, Fdx1, Fdx2, Fdxr, Fech, Fh1, Fhit, Flad1, Fpgs, Fth1, Ftmt, Fxn, Gatm, Gcat, Gcdh, Gcsh, Gldc, Glrx2, Glrx5, Gls, Gls2, Glud1, Glyat, Glyctk, Gm4952, Gm4984, Got2, Gpam, Gpat2, Gpd2, Gpt2, Gpx1, Gpx4, Grhpr, Grpel1, Grpel2, Gsr, Gstk1, Gstz1, Gtpbp3, Guk1, H2-Ke6, Hadh, Hadha, Hadhb, Hagh, Hao2, Hccs, Hibadh, Hibch, Hint1, Hint2, Hmgcl, Hmgcs2, Hoga1, Hscb, Hsd17b10, Hsd17b4, Hspa9, Htd2, Iba57, Idh2, Idh3a, Idh3b, Idh3g, Idi1, Isca1, Isca2, Iscu, Ivd, Kmo, Kyat3, L2hgdh, Lactb, Ldhal6b, Ldhb, Ldhd, Lias, Lipt1, Lipt2, Lypla1, Lyplal1, Lyrm4, Maoa, Maob, Mcat, Mccc1, Mccc2, Mcee, Mdh2, Me2, Me3, Mecr, Mgst1, Mgst3, Mlycd, Mmaa, Mmab, Mmadhc, Mmut, Mocs1, Mpc1, Mpc2, Mpst, Mrps36, Msra, Msrb2, Msrb3, mt-Co1, mt-Cytb, Mtarc1, Mtarc2, Mtfmt, Mthfd1l, Mthfd2, Mthfd2l, Mthfs, Mthfsl, Mto1, Nadk2, Nags, Nat8l, Naxd, Naxe, Ndufab1, Ndufs1, Ndufs2, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Neu4, Nfs1, Nfu1, Nit1, Nit2, Nme3, Nme4, Nme6, Nmnat3, Nnt, Noct, Nt5dc2, Nt5m, Nthl1, Nubpl, Nudt13, Nudt19, Nudt2, Nudt5, Nudt8, Nudt9, Oat, Ogdh, Ogdhl, Osbpl1a, Otc, Oxct1, Oxct2a, Oxr1, Oxsm, Paics, Pank2, Pcbd2, Pcca, Pccb, Pck2, Pcx, Pdha1, Pdha2, Pdhb, Pdhx, Pdk1, Pdk2, Pdk3, Pdk4, Pdp1, Pdp2, Pdpr, Pdss1, Pdss2, Pgs1, Phyh, Pisd, Pld6, Plpbp, Plscr3, Pnpla8, Pnpo, Ppa2, Ppm1k, Ppox, Prdx2, Prdx3, Prdx4, Prdx5, Prdx6, Prelid1, Prelid3a, Prelid3b, Prodh, Prodh2, Prxl2a, Ptges2, Ptpmt1, Pycr1, Pycr2, Qdpr, Rdh13, Rdh14, Rfk, Rpia, Rsad1, Sardh, Sco1, Sco2, Scp2, Sdha, Sdhb, Sdhc, Sdhd, Sdsl, Selenoo, Serac1, Sfxn1, Sfxn3, Sfxn5, Shmt2, Sirt3, Sirt4, Sirt5, Slc25a1, Slc25a10, Slc25a11, Slc25a12, Slc25a13, Slc25a14, Slc25a15, Slc25a19, Slc25a2, Slc25a20, Slc25a21, Slc25a23, Slc25a24, Slc25a25, Slc25a28, Slc25a29, Slc25a3, Slc25a30, Slc25a31, Slc25a32, Slc25a33, Slc25a36, Slc25a37, Slc25a38, Slc25a4, Slc25a41, Slc25a42, Slc25a44, Slc25a5, Slc25a51, Sod1, Sod2, Sphk2, Spr, Sptlc2, Sqor, Star, Stard7, Sucla2, Suclg1, Suclg2, Sugct, Suox, Tamm41, Taz, Them4, Them5, Tk2, Tmlhe, Triap1, Tspo, Tst, Tstd1, Txn2, Txnrd1, Txnrd2, Uqcrfs1, Zadh2",464,Metabolism,,
|
||||
Carbohydrate metabolism,Metabolism > Carbohydrate metabolism,"Abhd11, Acaa2, Acat1, Acly, Aco2, Acod1, Auh, Bdh1, Clybl, Cs, D2hgdh, Dcxr, Dlat, Dld, Dlst, Fahd1, Fh1, Glyctk, Gm4984, Got2, Gpd2, Hadhb, Hmgcl, Hmgcs2, Idh2, Idh3a, Idh3b, Idh3g, L2hgdh, Ldhal6b, Ldhd, Mcee, Mdh2, Me2, Me3, Mmut, Mpc1, Mpc2, Mrps36, Neu4, Ogdh, Ogdhl, Oxct1, Oxct2a, Pcca, Pccb, Pck2, Pcx, Pdha1, Pdha2, Pdhb, Pdhx, Pdk1, Pdk2, Pdk3, Pdk4, Pdp1, Pdp2, Pdpr, Rpia, Sdha, Sdhb, Sdhc, Sdhd, Sfxn5, Slc25a1, Slc25a10, Slc25a11, Slc25a12, Slc25a13, Sucla2, Suclg1, Suclg2",73,Metabolism,Carbohydrate metabolism,
|
||||
Gluconeogenesis,Metabolism > Carbohydrate metabolism > Gluconeogenesis,"Gm4984, Mdh2, Mpc1, Mpc2, Pck2, Pcx, Slc25a1, Slc25a10, Slc25a11",9,Metabolism,Carbohydrate metabolism,Gluconeogenesis
|
||||
Malate-aspartate shuttle,Metabolism > Carbohydrate metabolism > Malate-aspartate shuttle,"Got2, Mdh2, Slc25a10, Slc25a11, Slc25a12, Slc25a13",6,Metabolism,Carbohydrate metabolism,Malate-aspartate shuttle
|
||||
Glycerol phosphate shuttle,Metabolism > Carbohydrate metabolism > Glycerol phosphate shuttle,Gpd2,1,Metabolism,Carbohydrate metabolism,Glycerol phosphate shuttle
|
||||
Pyruvate metabolism,Metabolism > Carbohydrate metabolism > Pyruvate metabolism,"Dlat, Dld, Gm4984, Mpc1, Mpc2, Pdha1, Pdha2, Pdhb, Pdhx, Pdk1, Pdk2, Pdk3, Pdk4, Pdp1, Pdp2, Pdpr",16,Metabolism,Carbohydrate metabolism,Pyruvate metabolism
|
||||
TCA cycle,Metabolism > Carbohydrate metabolism > TCA cycle,"Aco2, Cs, Dld, Dlst, Fh1, Idh2, Idh3a, Idh3b, Idh3g, Mdh2, Mrps36, Ogdh, Ogdhl, Sdha, Sdhb, Sdhc, Sdhd, Sucla2, Suclg1, Suclg2",20,Metabolism,Carbohydrate metabolism,TCA cycle
|
||||
TCA-associated,Metabolism > Carbohydrate metabolism > TCA-associated,"Abhd11, Acly, D2hgdh, Fahd1, Gm4984, L2hgdh, Me2, Me3, Mpc1, Mpc2, Pck2, Pcx, Sfxn5, Slc25a1, Slc25a11",15,Metabolism,Carbohydrate metabolism,TCA-associated
|
||||
Itaconate metabolism,Metabolism > Carbohydrate metabolism > Itaconate metabolism,"Acod1, Auh, Clybl, Sucla2, Suclg1, Suclg2",6,Metabolism,Carbohydrate metabolism,Itaconate metabolism
|
||||
Ketone metabolism,Metabolism > Carbohydrate metabolism > Ketone metabolism,"Acaa2, Acat1, Bdh1, Hadhb, Hmgcl, Hmgcs2, Oxct1, Oxct2a",8,Metabolism,Carbohydrate metabolism,Ketone metabolism
|
||||
Propanoate metabolism,Metabolism > Carbohydrate metabolism > Propanoate metabolism,"Mcee, Mmut, Pcca, Pccb",4,Metabolism,Carbohydrate metabolism,Propanoate metabolism
|
||||
Lipid metabolism,Metabolism > Lipid metabolism,"Acaa1a, Acaa1b, Acaa2, Acaca, Acacb, Acad10, Acad11, Acad12, Acadl, Acadm, Acads, Acadsb, Acadvl, Acat1, Acot10, Acot11, Acot13, Acot2, Acot7, Acot9, Acp6, Acsf2, Acsf3, Acsl1, Acsl6, Acsm1, Acsm2, Acsm3, Acsm4, Acsm5, Acss1, Acss3, Agk, Agpat4, Agpat5, Akr1b7, Amacr, Cbr4, Chpt1, Cpt1a, Cpt1b, Cpt1c, Cpt2, Crat, Crls1, Crot, Cyb5r3, Cyp11a1, Cyp11b1, Cyp11b2, Cyp27a1, Dbi, Decr1, Dhrs1, Ech1, Echdc1, Echs1, Eci1, Eci2, Ehhadh, Ephx2, Etfa, Etfb, Etfdh, Fabp1, Fasn, Fdps, Fdx1, Fdxr, Gcsh, Gpam, Gpat2, H2-Ke6, Hadh, Hadha, Hadhb, Hao2, Hint2, Hsd17b10, Hsd17b4, Htd2, Idi1, Lactb, Lias, Lipt1, Lipt2, Lypla1, Lyplal1, Mcat, Mcee, Mecr, Mgst3, Mlycd, Mmut, Ndufab1, Osbpl1a, Oxsm, Pcca, Pccb, Pgs1, Phyh, Pisd, Pld6, Plscr3, Pnpla8, Prdx6, Prelid1, Prelid3a, Prelid3b, Ptges2, Ptpmt1, Scp2, Serac1, Slc25a1, Slc25a20, Sphk2, Sptlc2, Star, Stard7, Tamm41, Taz, Them4, Them5, Triap1, Tspo, Zadh2",126,Metabolism,Lipid metabolism,
|
||||
Fatty acid oxidation,Metabolism > Lipid metabolism > Fatty acid oxidation,"Acaa1a, Acaa2, Acacb, Acad10, Acad11, Acad12, Acadl, Acadm, Acads, Acadsb, Acadvl, Acat1, Acot11, Acsf2, Acsl1, Acsl6, Acsm1, Acsm2, Acsm3, Acsm4, Acsm5, Acss1, Amacr, Cpt1a, Cpt1b, Cpt1c, Cpt2, Crat, Crot, Decr1, Echs1, Eci1, Eci2, Etfa, Etfb, Etfdh, Hadh, Hadha, Hadhb, Hsd17b10, Mcee, Mmut, Pcca, Pccb, Slc25a20",45,Metabolism,Lipid metabolism,Fatty acid oxidation
|
||||
Type II fatty acid synthesis,Metabolism > Lipid metabolism > Type II fatty acid synthesis,"Acaca, Acsf3, Cbr4, H2-Ke6, Htd2, Mcat, Mecr, Ndufab1, Oxsm",9,Metabolism,Lipid metabolism,Type II fatty acid synthesis
|
||||
Lipoate insertion,Metabolism > Lipid metabolism > Lipoate insertion,"Gcsh, Lias, Lipt1, Lipt2",4,Metabolism,Lipid metabolism,Lipoate insertion
|
||||
Cardiolipin synthesis,Metabolism > Lipid metabolism > Cardiolipin synthesis,"Agpat4, Agpat5, Crls1, Gpam, Gpat2, Hadha, Pgs1, Pld6, Plscr3, Pnpla8, Prelid1, Prelid3a, Ptpmt1, Tamm41, Taz, Triap1",16,Metabolism,Lipid metabolism,Cardiolipin synthesis
|
||||
"Cholesterol, bile acid, steroid synthesis","Metabolism > Lipid metabolism > Cholesterol, bile acid, steroid synthesis","Cyp11a1, Cyp11b1, Cyp11b2, Cyp27a1, Dhrs1, Fdx1, Fdxr, H2-Ke6, Hint2, Hsd17b10, Osbpl1a, Scp2, Star, Tspo",14,Metabolism,Lipid metabolism,"Cholesterol, bile acid, steroid synthesis"
|
||||
Cholesterol-associated,Metabolism > Lipid metabolism > Cholesterol-associated,"Fdps, Idi1",2,Metabolism,Lipid metabolism,Cholesterol-associated
|
||||
Phospholipid metabolism,Metabolism > Lipid metabolism > Phospholipid metabolism,"Acp6, Agk, Agpat4, Agpat5, Akr1b7, Chpt1, Gpam, Gpat2, Lactb, Osbpl1a, Pgs1, Pisd, Pnpla8, Prdx6, Prelid1, Prelid3a, Prelid3b, Ptpmt1, Serac1, Sphk2, Sptlc2, Stard7, Tamm41, Triap1",24,Metabolism,Lipid metabolism,Phospholipid metabolism
|
||||
Eicosanoid metabolism,Metabolism > Lipid metabolism > Eicosanoid metabolism,"Mgst3, Ptges2, Zadh2",3,Metabolism,Lipid metabolism,Eicosanoid metabolism
|
||||
Amino acid metabolism,Metabolism > Amino acid metabolism,"Aadat, Aass, Abat, Acaa2, Acad8, Acadsb, Acat1, Adhfe1, Agmat, Agxt, Agxt2, Akr7a5, Aldh18a1, Aldh4a1, Aldh5a1, Aldh6a1, Aldh7a1, Aldh9a1, Amt, Arg2, Auh, Bcat2, Bckdha, Bckdhb, Bckdk, Car5a, Car5b, Chdh, Comt, Cps1, Dbt, Dglucy, Dhtkd1, Dld, Dlst, Dmgdh, Echs1, Etfa, Etfb, Etfdh, Gcat, Gcdh, Gcsh, Gldc, Gls, Gls2, Glud1, Glyat, Got2, Gpt2, Grhpr, Hadh, Hadha, Hadhb, Hibadh, Hibch, Hmgcl, Hoga1, Hsd17b10, Ivd, Kmo, Kyat3, Ldhb, Maoa, Maob, Mccc1, Mccc2, Nags, Nat8l, Oat, Otc, Ppm1k, Prodh, Prodh2, Pycr1, Pycr2, Sardh, Sdsl, Sfxn1, Sfxn3, Shmt2, Slc25a12, Slc25a13, Slc25a15, Slc25a2, Slc25a21, Slc25a29, Slc25a38, Slc25a44, Sugct",90,Metabolism,Amino acid metabolism,
|
||||
Branched-chain amino acid metabolism,Metabolism > Amino acid metabolism > Branched-chain amino acid metabolism,"Acad8, Acadsb, Acat1, Aldh6a1, Auh, Bcat2, Bckdha, Bckdhb, Bckdk, Dbt, Dld, Echs1, Etfa, Etfb, Etfdh, Hadha, Hibadh, Hibch, Hmgcl, Hsd17b10, Ivd, Mccc1, Mccc2, Ppm1k, Slc25a44",25,Metabolism,Amino acid metabolism,Branched-chain amino acid metabolism
|
||||
Branched-chain amino acid dehydrogenase complex,Metabolism > Amino acid metabolism > Branched-chain amino acid dehydrogenase complex,"Bckdha, Bckdhb, Bckdk, Dbt, Dld, Ppm1k",6,Metabolism,Amino acid metabolism,Branched-chain amino acid dehydrogenase complex
|
||||
Lysine metabolism,Metabolism > Amino acid metabolism > Lysine metabolism,"Aadat, Aass, Acaa2, Acat1, Aldh7a1, Dhtkd1, Dld, Dlst, Echs1, Etfa, Etfb, Etfdh, Gcdh, Hadh, Hadhb, Slc25a29",16,Metabolism,Amino acid metabolism,Lysine metabolism
|
||||
Serine metabolism,Metabolism > Amino acid metabolism > Serine metabolism,"Agxt, Sdsl, Sfxn1, Sfxn3, Shmt2",5,Metabolism,Amino acid metabolism,Serine metabolism
|
||||
Glycine metabolism,Metabolism > Amino acid metabolism > Glycine metabolism,"Aldh7a1, Amt, Chdh, Dld, Dmgdh, Etfa, Etfb, Etfdh, Gcat, Gcsh, Gldc, Glyat, Sardh, Shmt2, Slc25a38",15,Metabolism,Amino acid metabolism,Glycine metabolism
|
||||
Glycine cleavage system,Metabolism > Amino acid metabolism > Glycine cleavage system,"Amt, Dld, Gcsh, Gldc",4,Metabolism,Amino acid metabolism,Glycine cleavage system
|
||||
Glutamate metabolism,Metabolism > Amino acid metabolism > Glutamate metabolism,"Gls, Gls2, Glud1, Got2, Gpt2, Nat8l, Slc25a12",7,Metabolism,Amino acid metabolism,Glutamate metabolism
|
||||
Proline metabolism,Metabolism > Amino acid metabolism > Proline metabolism,"Aldh18a1, Aldh4a1, Oat, Prodh, Pycr1, Pycr2",6,Metabolism,Amino acid metabolism,Proline metabolism
|
||||
Glyoxylate metabolism,Metabolism > Amino acid metabolism > Glyoxylate metabolism,"Agxt, Agxt2, Aldh4a1, Got2, Grhpr, Hoga1, Ldhb, Prodh2",8,Metabolism,Amino acid metabolism,Glyoxylate metabolism
|
||||
GABA metabolism,Metabolism > Amino acid metabolism > GABA metabolism,"Abat, Adhfe1, Akr7a5, Aldh5a1, Aldh9a1, Glud1",6,Metabolism,Amino acid metabolism,GABA metabolism
|
||||
Catechol metabolism,Metabolism > Amino acid metabolism > Catechol metabolism,"Comt, Maoa, Maob",3,Metabolism,Amino acid metabolism,Catechol metabolism
|
||||
Kynurenine metabolism,Metabolism > Amino acid metabolism > Kynurenine metabolism,"Got2, Kmo, Kyat3",3,Metabolism,Amino acid metabolism,Kynurenine metabolism
|
||||
Urea cycle,Metabolism > Amino acid metabolism > Urea cycle,"Car5a, Car5b, Cps1, Nags, Otc, Slc25a13, Slc25a15, Slc25a2",8,Metabolism,Amino acid metabolism,Urea cycle
|
||||
Nucleotide metabolism,Metabolism > Nucleotide metabolism,"Ak2, Ak3, Ak4, Antkmt, Ckmt1, Ckmt2, Cmpk2, Dguok, Dhodh, Dut, Fhit, Gatm, Guk1, Hint1, Nme3, Nme4, Nme6, Nt5dc2, Nt5m, Nudt2, Nudt5, Nudt9, Paics, Ppa2, Slc25a23, Slc25a24, Slc25a25, Slc25a31, Slc25a33, Slc25a36, Slc25a4, Slc25a41, Slc25a5, Sucla2, Suclg1, Tk2",36,Metabolism,Nucleotide metabolism,
|
||||
Nucleotide import,Metabolism > Nucleotide metabolism > Nucleotide import,"Slc25a23, Slc25a24, Slc25a25, Slc25a31, Slc25a33, Slc25a36, Slc25a4, Slc25a41, Slc25a5",9,Metabolism,Nucleotide metabolism,Nucleotide import
|
||||
Nucleotide synthesis and processing,Metabolism > Nucleotide metabolism > Nucleotide synthesis and processing,"Ak2, Ak3, Ak4, Cmpk2, Dguok, Dhodh, Dut, Fhit, Guk1, Hint1, Nme3, Nme4, Nme6, Nt5dc2, Nt5m, Nudt2, Nudt5, Nudt9, Paics, Sucla2, Suclg1, Tk2",22,Metabolism,Nucleotide metabolism,Nucleotide synthesis and processing
|
||||
Creatine metabolism,Metabolism > Nucleotide metabolism > Creatine metabolism,"Ckmt1, Ckmt2, Gatm",3,Metabolism,Nucleotide metabolism,Creatine metabolism
|
||||
Metals and cofactors,Metabolism > Metals and cofactors,"Abat, Abcb10, Abcb6, Abcb7, Aco2, Aifm3, Alas1, Alas2, Bola1, Bola3, Chchd7, Cisd1, Cisd3, Coasy, Coq10a, Coq10b, Coq2, Coq3, Coq4, Coq5, Coq6, Coq7, Coq8a, Coq8b, Coq9, Cox10, Cox11, Cox15, Cox17, Cox19, Cpox, Cpt1a, Cpt1b, Cpt1c, Cpt2, Cyb5b, Cyc1, Cycs, Cyp11a1, Cyp11b2, Cyp24a1, Cyp27a1, Cyp27b1, Dna2, Etfdh, Fabp1, Fam210b, Fdx1, Fdx2, Fdxr, Fech, Fth1, Ftmt, Fxn, Glrx2, Glrx5, Grpel1, Grpel2, Hccs, Hscb, Hspa9, Iba57, Isca1, Isca2, Iscu, Kmo, Kyat3, Lias, Lyrm4, Mocs1, mt-Co1, mt-Cytb, Mtarc1, Mtarc2, Nadk2, Naxd, Naxe, Ndufab1, Ndufs1, Ndufs2, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Nfs1, Nfu1, Nmnat3, Nnt, Noct, Nthl1, Nubpl, Nudt13, Nudt19, Nudt8, Pank2, Pcbd2, Pdss1, Pdss2, Ppox, Qdpr, Rsad1, Sco1, Sco2, Sdhb, Sdhc, Sdhd, Sirt3, Sirt4, Sirt5, Slc25a20, Slc25a28, Slc25a3, Slc25a37, Slc25a38, Slc25a42, Slc25a51, Spr, Suox, Tmlhe, Uqcrfs1",120,Metabolism,Metals and cofactors,
|
||||
Carnitine synthesis and transport,Metabolism > Metals and cofactors > Carnitine synthesis and transport,"Cpt1a, Cpt1b, Cpt1c, Cpt2, Slc25a20, Tmlhe",6,Metabolism,Metals and cofactors,Carnitine synthesis and transport
|
||||
Carnitine shuttle,Metabolism > Metals and cofactors > Carnitine shuttle,"Cpt1a, Cpt1b, Cpt1c, Cpt2, Slc25a20",5,Metabolism,Metals and cofactors,Carnitine shuttle
|
||||
Coenzyme A metabolism,Metabolism > Metals and cofactors > Coenzyme A metabolism,"Coasy, Nudt19, Nudt8, Pank2, Slc25a42",5,Metabolism,Metals and cofactors,Coenzyme A metabolism
|
||||
Coenzyme Q metabolism,Metabolism > Metals and cofactors > Coenzyme Q metabolism,"Coq10a, Coq10b, Coq2, Coq3, Coq4, Coq5, Coq6, Coq7, Coq8a, Coq8b, Coq9, Pdss1, Pdss2",13,Metabolism,Metals and cofactors,Coenzyme Q metabolism
|
||||
Copper metabolism,Metabolism > Metals and cofactors > Copper metabolism,"Chchd7, Cox11, Cox17, Cox19, Sco1, Sco2, Slc25a3",7,Metabolism,Metals and cofactors,Copper metabolism
|
||||
Iron homeostasis,Metabolism > Metals and cofactors > Iron homeostasis,"Fam210b, Fth1, Ftmt, Slc25a28, Slc25a37",5,Metabolism,Metals and cofactors,Iron homeostasis
|
||||
Heme synthesis and processing,Metabolism > Metals and cofactors > Heme synthesis and processing,"Abcb10, Abcb6, Abcb7, Alas1, Alas2, Cox10, Cox15, Cpox, Fabp1, Fdx1, Fdx2, Fdxr, Fech, Hccs, Ppox, Slc25a38",16,Metabolism,Metals and cofactors,Heme synthesis and processing
|
||||
Fe-S cluster biosynthesis,Metabolism > Metals and cofactors > Fe-S cluster biosynthesis,"Abcb7, Bola1, Bola3, Cisd1, Cisd3, Fdx1, Fdx2, Fdxr, Fxn, Glrx5, Grpel1, Grpel2, Hscb, Hspa9, Iba57, Isca1, Isca2, Iscu, Lyrm4, Ndufab1, Nfs1, Nfu1, Nubpl",23,Metabolism,Metals and cofactors,Fe-S cluster biosynthesis
|
||||
Molybdenum cofactor synthesis and proteins,Metabolism > Metals and cofactors > Molybdenum cofactor synthesis and proteins,"Abcb7, Mocs1, Mtarc1, Mtarc2, Suox",5,Metabolism,Metals and cofactors,Molybdenum cofactor synthesis and proteins
|
||||
NAD biosynthesis and metabolism,Metabolism > Metals and cofactors > NAD biosynthesis and metabolism,"Kmo, Kyat3, Nadk2, Naxd, Naxe, Nmnat3, Nnt, Noct, Nudt13, Sirt3, Sirt4, Sirt5, Slc25a51",13,Metabolism,Metals and cofactors,NAD biosynthesis and metabolism
|
||||
Tetrahydrobiopterin synthesis,Metabolism > Metals and cofactors > Tetrahydrobiopterin synthesis,"Pcbd2, Qdpr, Spr",3,Metabolism,Metals and cofactors,Tetrahydrobiopterin synthesis
|
||||
Fe-S-containing proteins,Metabolism > Metals and cofactors > Fe-S-containing proteins,"Abat, Aco2, Aifm3, Bola1, Bola3, Cisd1, Cisd3, Dna2, Etfdh, Fdx1, Fdx2, Fech, Glrx2, Glrx5, Isca1, Isca2, Iscu, Lias, Ndufs1, Ndufs2, Ndufs7, Ndufs8, Ndufv1, Ndufv2, Nfs1, Nfu1, Nthl1, Nubpl, Rsad1, Sdhb, Uqcrfs1",31,Metabolism,Metals and cofactors,Fe-S-containing proteins
|
||||
Heme-containing proteins,Metabolism > Metals and cofactors > Heme-containing proteins,"Cyb5b, Cyc1, Cycs, Cyp11a1, Cyp11b2, Cyp24a1, Cyp27a1, Cyp27b1, mt-Co1, mt-Cytb, Sdhc, Sdhd",12,Metabolism,Metals and cofactors,Heme-containing proteins
|
||||
Vitamin metabolism,Metabolism > Vitamin metabolism,"Acaca, Acacb, Akr1b10, Aldh1l1, Aldh1l2, Aldh7a1, Amt, Bco2, Chdh, Cyp24a1, Cyp27b1, Dhrs4, Dmgdh, Etfa, Etfb, Etfdh, Fdx1, Fdxr, Flad1, Fpgs, Glrx2, Gtpbp3, Mccc1, Mmaa, Mmab, Mmadhc, Mmut, Mtfmt, Mthfd1l, Mthfd2, Mthfd2l, Mthfs, Mthfsl, Mto1, Pcca, Pcx, Plpbp, Pnpo, Qdpr, Rdh13, Rdh14, Rfk, Sardh, Sfxn1, Sfxn3, Shmt2, Slc25a19, Slc25a32, Slc25a38, Txn2",50,Metabolism,Vitamin metabolism,
|
||||
Choline and betaine metabolism,Metabolism > Vitamin metabolism > Choline and betaine metabolism,"Aldh7a1, Chdh, Dmgdh, Etfa, Etfb, Etfdh, Sardh",7,Metabolism,Vitamin metabolism,Choline and betaine metabolism
|
||||
Biotin utilizing proteins,Metabolism > Vitamin metabolism > Biotin utilizing proteins,"Acaca, Acacb, Mccc1, Pcca, Pcx",5,Metabolism,Vitamin metabolism,Biotin utilizing proteins
|
||||
Vitamin A metabolism,Metabolism > Vitamin metabolism > Vitamin A metabolism,"Akr1b10, Bco2, Dhrs4, Rdh13, Rdh14",5,Metabolism,Vitamin metabolism,Vitamin A metabolism
|
||||
Vitamin B1 metabolism,Metabolism > Vitamin metabolism > Vitamin B1 metabolism,Slc25a19,1,Metabolism,Vitamin metabolism,Vitamin B1 metabolism
|
||||
Vitamin B2 metabolism,Metabolism > Vitamin metabolism > Vitamin B2 metabolism,"Flad1, Rfk, Slc25a32",3,Metabolism,Vitamin metabolism,Vitamin B2 metabolism
|
||||
Vitamin B6 metabolism,Metabolism > Vitamin metabolism > Vitamin B6 metabolism,"Plpbp, Pnpo",2,Metabolism,Vitamin metabolism,Vitamin B6 metabolism
|
||||
Vitamin B12 metabolism,Metabolism > Vitamin metabolism > Vitamin B12 metabolism,"Mmaa, Mmab, Mmadhc, Mmut",4,Metabolism,Vitamin metabolism,Vitamin B12 metabolism
|
||||
Vitamin C metabolism,Metabolism > Vitamin metabolism > Vitamin C metabolism,"Glrx2, Txn2",2,Metabolism,Vitamin metabolism,Vitamin C metabolism
|
||||
Vitamin D metabolism,Metabolism > Vitamin metabolism > Vitamin D metabolism,"Cyp24a1, Cyp27b1, Fdx1, Fdxr",4,Metabolism,Vitamin metabolism,Vitamin D metabolism
|
||||
Folate and 1-C metabolism,Metabolism > Vitamin metabolism > Folate and 1-C metabolism,"Aldh1l1, Aldh1l2, Aldh7a1, Amt, Chdh, Dmgdh, Fpgs, Gtpbp3, Mtfmt, Mthfd1l, Mthfd2, Mthfd2l, Mthfs, Mthfsl, Mto1, Qdpr, Sardh, Sfxn1, Sfxn3, Shmt2, Slc25a32, Slc25a38",22,Metabolism,Vitamin metabolism,Folate and 1-C metabolism
|
||||
Detoxification,Metabolism > Detoxification,"Abhd10, Acsm2, Acsm5, Aifm2, Akr1b10, Akr7a5, Aldh1b1, Aldh2, Aldh3a2, Aldh7a1, Aldh9a1, Bphl, Cat, Cbr3, Cyb5b, Cyb5r3, Dhrs2, Ephx2, Glrx2, Glyat, Gpx1, Gpx4, Gsr, Gstk1, Gstz1, Hagh, Maoa, Maob, Mgst1, Mpst, Msra, Msrb2, Msrb3, Mtarc1, Mtarc2, Nit1, Nit2, Oxr1, Prdx2, Prdx3, Prdx4, Prdx5, Prdx6, Prxl2a, Selenoo, Sod1, Sod2, Tst, Txn2, Txnrd1, Txnrd2",51,Metabolism,Detoxification,
|
||||
Xenobiotic metabolism,Metabolism > Detoxification > Xenobiotic metabolism,"Abhd10, Acsm2, Acsm5, Akr1b10, Akr7a5, Aldh1b1, Aldh2, Bphl, Cbr3, Cyb5b, Cyb5r3, Dhrs2, Ephx2, Glyat, Gstk1, Gstz1, Maoa, Maob, Mgst1, Mpst, Mtarc1, Mtarc2, Tst",23,Metabolism,Detoxification,Xenobiotic metabolism
|
||||
ROS and glutathione metabolism,Metabolism > Detoxification > ROS and glutathione metabolism,"Aifm2, Aldh3a2, Aldh7a1, Aldh9a1, Cat, Glrx2, Gpx1, Gpx4, Gsr, Hagh, Mgst1, Msra, Msrb2, Msrb3, Nit1, Oxr1, Prdx2, Prdx3, Prdx4, Prdx5, Prdx6, Prxl2a, Sod1, Sod2, Txn2, Txnrd1, Txnrd2",27,Metabolism,Detoxification,ROS and glutathione metabolism
|
||||
Amidoxime reducing complex,Metabolism > Detoxification > Amidoxime reducing complex,"Cyb5b, Cyb5r3, Mtarc1, Mtarc2",4,Metabolism,Detoxification,Amidoxime reducing complex
|
||||
Selenoproteins,Metabolism > Detoxification > Selenoproteins,"Gpx1, Gpx4, Selenoo, Txnrd1, Txnrd2",5,Metabolism,Detoxification,Selenoproteins
|
||||
Electron carriers,Metabolism > Electron carriers,"Chdh, Cyb5b, Cyc1, Cycs, Cyct, Dhodh, Etfa, Etfb, Etfbkmt, Etfdh, Etfrf1, Gpd2, mt-Cytb, Prodh, Prodh2, Sqor",16,Metabolism,Electron carriers,
|
||||
Cytochromes,Metabolism > Electron carriers > Cytochromes,"Cyb5b, Cyc1, Cycs, Cyct, mt-Cytb",5,Metabolism,Electron carriers,Cytochromes
|
||||
"Q-linked reactions, other","Metabolism > Electron carriers > Q-linked reactions, other","Chdh, Dhodh, Etfa, Etfb, Etfbkmt, Etfdh, Etfrf1, Gpd2, Prodh, Prodh2, Sqor",11,Metabolism,Electron carriers,"Q-linked reactions, other"
|
||||
Sulfur metabolism,Metabolism > Sulfur metabolism,"Ethe1, Got2, Mpst, Msra, Msrb2, Slc25a14, Slc25a30, Sqor, Suox, Tst, Tstd1",11,Metabolism,Sulfur metabolism,
|
||||
Small molecule transport,Small molecule transport,"Abca9, Abcb10, Abcb6, Abcb7, Abcb8, Abcd1, Abcd2, Abcd3, Ccdc51, Gm4984, Letmd1, Mcu, Mcub, Micu1, Micu2, Micu3, Mpc1, Mpc2, Mpv17, Mpv17l, Mrs2, Mtch1, Mtch2, Romo1, Sfxn1, Sfxn2, Sfxn3, Sfxn4, Sfxn5, Slc25a1, Slc25a10, Slc25a11, Slc25a12, Slc25a13, Slc25a14, Slc25a15, Slc25a16, Slc25a18, Slc25a19, Slc25a2, Slc25a20, Slc25a21, Slc25a22, Slc25a23, Slc25a24, Slc25a25, Slc25a26, Slc25a27, Slc25a28, Slc25a29, Slc25a3, Slc25a30, Slc25a31, Slc25a32, Slc25a33, Slc25a34, Slc25a35, Slc25a36, Slc25a37, Slc25a38, Slc25a39, Slc25a4, Slc25a40, Slc25a41, Slc25a42, Slc25a43, Slc25a44, Slc25a45, Slc25a46, Slc25a47, Slc25a48, Slc25a5, Slc25a51, Slc25a53, Slc25a54, Slc30a9, Slc8b1, Smdt1, Stard7, Ucp1, Ucp2, Ucp3, Vdac1, Vdac2, Vdac3",85,Small molecule transport,,
|
||||
SLC25A family,Small molecule transport > SLC25A family,"Mtch1, Mtch2, Slc25a1, Slc25a10, Slc25a11, Slc25a12, Slc25a13, Slc25a14, Slc25a15, Slc25a16, Slc25a18, Slc25a19, Slc25a2, Slc25a20, Slc25a21, Slc25a22, Slc25a23, Slc25a24, Slc25a25, Slc25a26, Slc25a27, Slc25a28, Slc25a29, Slc25a3, Slc25a30, Slc25a31, Slc25a32, Slc25a33, Slc25a34, Slc25a35, Slc25a36, Slc25a37, Slc25a38, Slc25a39, Slc25a4, Slc25a40, Slc25a41, Slc25a42, Slc25a43, Slc25a44, Slc25a45, Slc25a46, Slc25a47, Slc25a48, Slc25a5, Slc25a51, Slc25a53, Slc25a54, Ucp1, Ucp2, Ucp3",51,Small molecule transport,SLC25A family,
|
||||
ABC transporters,Small molecule transport > ABC transporters,"Abca9, Abcb10, Abcb6, Abcb7, Abcb8, Abcd1, Abcd2, Abcd3",8,Small molecule transport,ABC transporters,
|
||||
Sideroflexins,Small molecule transport > Sideroflexins,"Sfxn1, Sfxn2, Sfxn3, Sfxn4, Sfxn5",5,Small molecule transport,Sideroflexins,
|
||||
Signaling,Signaling,"Acod1, Adcy10, Akap1, Akap10, Bloc1s1, C1qbp, Cstad, Dele1, Efhd1, Fundc2, Ifi27, Letm1, Lypla1, Macrod1, Mavs, Mcrip2, Mcu, Mcub, Micu1, Micu2, Micu3, Mrs2, Mul1, Nlrx1, Ociad2, Pde2a, Pink1, Ppif, Pptc7, Prkaca, Rhot1, Rhot2, Sirt3, Slc25a12, Slc25a13, Slc25a23, Slc25a24, Slc25a25, Slc25a3, Slc25a31, Slc25a4, Slc25a5, Slc8b1, Smdt1, Sphkap, Vdac1, Vdac3",47,Signaling,,
|
||||
Calcium homeostasis,Signaling > Calcium homeostasis,"Efhd1, Letm1, Mcu, Mcub, Micu1, Micu2, Micu3, Ppif, Rhot1, Rhot2, Slc25a12, Slc25a13, Slc25a23, Slc25a24, Slc25a25, Slc25a3, Slc25a31, Slc25a4, Slc25a5, Slc8b1, Smdt1, Vdac1, Vdac3",23,Signaling,Calcium homeostasis,
|
||||
Calcium uniporter,Small molecule transport > Calcium uniporter,"Mcu, Mcub, Micu1, Micu2, Micu3, Smdt1",6,Small molecule transport,Calcium uniporter,
|
||||
Calcium cycle,Signaling > Calcium homeostasis > Calcium cycle,"Letm1, Mcu, Mcub, Micu1, Micu2, Micu3, Slc25a3, Slc8b1, Smdt1",9,Signaling,Calcium homeostasis,Calcium cycle
|
||||
Mitochondrial permeability transition pore,Signaling > Calcium homeostasis > Mitochondrial permeability transition pore,"Ppif, Slc25a31, Slc25a4, Slc25a5, Vdac1, Vdac3",6,Signaling,Calcium homeostasis,Mitochondrial permeability transition pore
|
||||
EF hand proteins,Signaling > Calcium homeostasis > EF hand proteins,"Efhd1, Micu1, Micu2, Micu3, Rhot1, Rhot2, Slc25a12, Slc25a13, Slc25a23, Slc25a24, Slc25a25",11,Signaling,Calcium homeostasis,EF hand proteins
|
||||
Immune response,Signaling > Immune response,"Acod1, C1qbp, Cstad, Ifi27, Mavs, Nlrx1",6,Signaling,Immune response,
|
||||
cAMP-PKA signaling,Signaling > cAMP-PKA signaling,"Adcy10, Akap1, Akap10, Pde2a, Prkaca, Sphkap",6,Signaling,cAMP-PKA signaling,
|
||||
Mitochondrial dynamics and surveillance,Mitochondrial dynamics and surveillance,"Ahcyl1, Aifm1, Aifm2, Aifm3, Apoo, Apool, Arl2, Armc10, Armcx1, Armcx3, Atad3a, Atp5k, Atp5l, Atp5md, Bad, Bak1, Bax, Bbc3, Bcl2, Bcl2a1d, Bcl2l1, Bcl2l10, Bcl2l11, Bcl2l13, Bcl2l2, Bid, Bik, Bnip3, Bnip3l, Bok, Casp3, Casp8, Casp9, Chchd2, Chchd3, Chchd6, Cycs, Diablo, Dnajc11, Dnm1l, Endog, Fis1, Fkbp8, Fundc1, Fundc2, Ghitm, Htra2, Ifi27, Immt, Marchf5, Mcl1, Mff, Mfn1, Mfn2, Mgarp, Micos10, Micos13, Mief1, Mief2, Miga1, Miga2, Mtch2, Mtfp1, Mtfr1, Mtfr2, Mtx1, Mtx2, Mtx3, Mul1, Myo19, Nbr1, Nipsnap1, Nipsnap2, Oma1, Opa1, Park7, Parl, Pgam5, Pigbos1, Pink1, Pld6, Pmaip1, Prkn, Rab24, Rhot1, Rhot2, Rmdn3, Samm50, Septin4, Slc25a46, Snap29, Sphk2, Spire1, Stx17, Styxl1, Synj2bp, Tmem11, Tomm20, Tomm7, Usp30, Vdac1, Vps13d",102,Mitochondrial dynamics and surveillance,,
|
||||
Fusion,Mitochondrial dynamics and surveillance > Fusion,"Arl2, Mfn1, Mfn2, Miga1, Miga2, Mtch2, Oma1, Opa1, Pld6",9,Mitochondrial dynamics and surveillance,Fusion,
|
||||
Fission,Mitochondrial dynamics and surveillance > Fission,"Armc10, Dnm1l, Fis1, Mff, Mief1, Mief2, Mtfp1, Mtfr1, Mtfr2, Mul1, Oma1, Rab24, Slc25a46, Spire1, Stx17",15,Mitochondrial dynamics and surveillance,Fission,
|
||||
Organelle contact sites,Mitochondrial dynamics and surveillance > Organelle contact sites,"Ahcyl1, Atad3a, Fkbp8, Fundc2, Mfn1, Mfn2, Miga2, Pigbos1, Rmdn3, Spire1, Stx17, Synj2bp, Vdac1",13,Mitochondrial dynamics and surveillance,Organelle contact sites,
|
||||
Intramitochondrial membrane interactions,Mitochondrial dynamics and surveillance > Intramitochondrial membrane interactions,"Atad3a, Chchd3, Dnajc11, Mtx1, Mtx2, Mtx3, Samm50, Slc25a46",8,Mitochondrial dynamics and surveillance,Intramitochondrial membrane interactions,
|
||||
Trafficking,Mitochondrial dynamics and surveillance > Trafficking,"Armc10, Armcx1, Armcx3, Mgarp, Myo19, Rhot1, Rhot2",7,Mitochondrial dynamics and surveillance,Trafficking,
|
||||
Mitophagy,Mitochondrial dynamics and surveillance > Mitophagy,"Bcl2l13, Fkbp8, Fundc1, Marchf5, Nipsnap1, Nipsnap2, Park7, Parl, Pgam5, Pink1, Prkn, Tomm7, Usp30, Vps13d",14,Mitochondrial dynamics and surveillance,Mitophagy,
|
||||
Autophagy,Mitochondrial dynamics and surveillance > Autophagy,"Bcl2l13, Fkbp8, Fundc1, Marchf5, Nbr1, Nipsnap1, Nipsnap2, Park7, Parl, Pgam5, Pink1, Prkn, Rab24, Snap29, Stx17, Tomm7, Usp30, Vps13d",18,Mitochondrial dynamics and surveillance,Autophagy,
|
||||
Apoptosis,Mitochondrial dynamics and surveillance > Apoptosis,"Aifm1, Aifm2, Aifm3, Bad, Bak1, Bax, Bbc3, Bcl2, Bcl2a1d, Bcl2l1, Bcl2l10, Bcl2l11, Bcl2l13, Bcl2l2, Bid, Bik, Bnip3, Bnip3l, Bok, Casp3, Casp8, Casp9, Chchd2, Cycs, Diablo, Endog, Ghitm, Htra2, Ifi27, Mcl1, Pmaip1, Septin4, Sphk2, Styxl1",34,Mitochondrial dynamics and surveillance,Apoptosis,
|
||||
Cristae formation,Mitochondrial dynamics and surveillance > Cristae formation,"Apoo, Apool, Atp5k, Atp5l, Atp5md, Chchd3, Chchd6, Immt, Micos10, Micos13, Opa1",11,Mitochondrial dynamics and surveillance,Cristae formation,
|
||||
MICOS complex,Mitochondrial dynamics and surveillance > Cristae formation > MICOS complex,"Apoo, Apool, Chchd3, Chchd6, Immt, Micos10, Micos13",7,Mitochondrial dynamics and surveillance,Cristae formation,MICOS complex
|
||||
|
@@ -0,0 +1,149 @@
|
||||
Mitochondrial central dogma MitoCarta3.0 2810006K23Rik Aars2 Alkbh1 Angel2 Apex1 Atad3a Aurkaip1 Cars2 Cdk5rap1 Chchd1 Coa3 Cox14 Dap3 Dars2 Ddx28 Dhx30 Dna2 Dus2 Ears2 Elac2 Endog Eral1 Exd2 Exog Fars2 Fastk Fastkd1 Fastkd2 Fastkd3 Fastkd5 Gadd45gip1 Gars Gatb Gatc Gfm1 Gfm2 Grsf1 Gtpbp10 Gtpbp3 Guf1 Hars2 Hemk1 Hsd17b10 Iars2 Kars Lactb2 Lars2 Lig3 Lrpprc Malsu1 Mars2 Metap1d Mettl15 Mettl17 Mettl4 Mettl5 Mettl8 Mgme1 Mief1 Mpv17l2 Mrm1 Mrm2 Mrm3 Mrpl1 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Mrpl2 Mrpl20 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Mrpl3 Mrpl30 Mrpl32 Mrpl33 Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrpl4 Mrpl40 Mrpl41 Mrpl42 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl47 Mrpl48 Mrpl49 Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl54 Mrpl55 Mrpl57 Mrpl58 Mrpl9 Mrps10 Mrps11 Mrps12 Mrps14 Mrps15 Mrps16 Mrps17 Mrps18a Mrps18b Mrps18c Mrps2 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrps28 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrps36 Mrps5 Mrps6 Mrps7 Mrps9 Mrrf Mterf1a Mterf1b Mterf2 Mterf3 Mterf4 Mtfmt Mtg1 Mtg2 Mtif2 Mtif3 Mto1 Mtpap Mtres1 Mtrf1 Mtrf1l Mutyh Myg1 Nars2 Ngrn Noa1 Nsun2 Nsun3 Nsun4 Ogg1 Osgepl1 Oxa1l Pars2 Pde12 Pdf Pif1 Pnpt1 Polb Poldip2 Polg Polg2 Polq Polrmt Ppa2 Primpol Prorp Ptcd1 Ptcd2 Ptcd3 Pus1 Pusl1 Qrsl1 Qtrt1 Rars2 Rbfa Rcc1l Recql4 Rexo2 Rmnd1 Rnaseh1 Rpusd3 Rpusd4 Sars2 Slirp Ssbp1 Supv3l1 Taco1 Tars2 Tbrg4 Tefm Tfam Tfb1m Tfb2m Thg1l Timm21 Top1mt Top3a Trit1 Trmt1 Trmt10c Trmt2b Trmt5 Trmu Trnt1 Trub2 Tsfm Tufm Twnk Ung Vars2 Wars2 Yars2 Ybey Yrdc
|
||||
Mitochondrial central dogma > mtDNA maintenance MitoCarta3.0 Apex1 Atad3a Dna2 Endog Exog Lig3 Mettl4 Mgme1 Mterf1a Mterf1b Mterf2 Mutyh Ogg1 Pif1 Polb Poldip2 Polg Polg2 Polq Polrmt Ppa2 Primpol Recql4 Rnaseh1 Ssbp1 Tfam Tfb2m Top1mt Top3a Twnk Ung
|
||||
Mitochondrial central dogma > mtDNA maintenance > mtDNA replication MitoCarta3.0 Dna2 Exog Lig3 Mgme1 Polg Polg2 Polrmt Rnaseh1 Ssbp1 Tfam Tfb2m Top1mt Top3a Twnk
|
||||
Mitochondrial central dogma > mtDNA maintenance > mtDNA nucleoid MitoCarta3.0 Atad3a Mterf1a Mterf1b Mterf2 Poldip2 Polg Polg2 Polrmt Ssbp1 Tfam Twnk
|
||||
Mitochondrial central dogma > mtDNA maintenance > mtDNA repair MitoCarta3.0 Apex1 Exog Lig3 Ogg1 Polb Polg Primpol Recql4 Ung
|
||||
Mitochondrial central dogma > mtDNA maintenance > mtDNA modifications MitoCarta3.0 Mettl4
|
||||
Mitochondrial central dogma > mtDNA maintenance > mtDNA stability and decay MitoCarta3.0 Endog Exog Mgme1
|
||||
Mitochondrial central dogma > mtRNA metabolism MitoCarta3.0 Alkbh1 Angel2 Cdk5rap1 Ddx28 Dhx30 Dus2 Elac2 Endog Eral1 Fastk Fastkd1 Fastkd2 Fastkd3 Fastkd5 Grsf1 Gtpbp3 Hsd17b10 Lactb2 Lrpprc Mettl15 Mettl17 Mettl5 Mettl8 Mrm1 Mrm2 Mrm3 Mrpl12 Mrpl47 Mrps7 Mrps9 Mterf1a Mterf1b Mto1 Mtpap Mtres1 Myg1 Ngrn Noa1 Nsun2 Nsun3 Nsun4 Osgepl1 Pde12 Pnpt1 Polrmt Ppa2 Prorp Ptcd1 Ptcd2 Pus1 Qtrt1 Rcc1l Rexo2 Rmnd1 Rnaseh1 Rpusd3 Rpusd4 Slirp Supv3l1 Tbrg4 Tefm Tfam Tfb1m Tfb2m Thg1l Top1mt Trit1 Trmt1 Trmt10c Trmt2b Trmt5 Trmu Trnt1 Trub2 Ybey Yrdc
|
||||
Mitochondrial central dogma > mtRNA metabolism > Transcription MitoCarta3.0 Mrpl12 Mterf1a Mterf1b Mtres1 Polrmt Tefm Tfam Tfb2m Top1mt
|
||||
Mitochondrial central dogma > mtRNA metabolism > mtRNA granules MitoCarta3.0 Alkbh1 Ddx28 Dhx30 Eral1 Fastk Fastkd1 Fastkd2 Fastkd5 Grsf1 Hsd17b10 Mrm1 Mrm2 Mrpl47 Mrps7 Mrps9 Mtpap Noa1 Prorp Ptcd1 Ptcd2 Pus1 Rmnd1 Rpusd3 Rpusd4 Supv3l1 Tfb1m Trmt10c Trub2
|
||||
Mitochondrial central dogma > mtRNA metabolism > Polycistronic mtRNA processing MitoCarta3.0 Elac2 Fastk Fastkd1 Fastkd2 Fastkd3 Fastkd5 Grsf1 Hsd17b10 Prorp Ptcd2 Tbrg4 Trmt10c Ybey
|
||||
Mitochondrial central dogma > mtRNA metabolism > mt-tRNA modifications MitoCarta3.0 Alkbh1 Cdk5rap1 Dus2 Gtpbp3 Hsd17b10 Mto1 Nsun2 Nsun3 Osgepl1 Pus1 Qtrt1 Rpusd4 Thg1l Trit1 Trmt1 Trmt10c Trmt2b Trmt5 Trmu Trnt1 Yrdc
|
||||
Mitochondrial central dogma > mtRNA metabolism > mt-rRNA modifications MitoCarta3.0 Mettl15 Mettl17 Mettl5 Mrm1 Mrm2 Mrm3 Mtpap Myg1 Ngrn Nsun4 Rcc1l Rpusd3 Rpusd4 Tfb1m Trit1 Trmt2b Trub2
|
||||
Mitochondrial central dogma > mtRNA metabolism > mt-mRNA modifications MitoCarta3.0 Angel2 Mtpap Myg1 Pde12
|
||||
Mitochondrial central dogma > mtRNA metabolism > mtRNA stability and decay MitoCarta3.0 Endog Fastk Fastkd1 Fastkd2 Fastkd3 Fastkd5 Grsf1 Lactb2 Lrpprc Mtpap Pde12 Pnpt1 Rexo2 Rnaseh1 Slirp Supv3l1 Tbrg4
|
||||
Mitochondrial central dogma > Translation MitoCarta3.0 2810006K23Rik Aars2 Aurkaip1 Cars2 Chchd1 Coa3 Cox14 Dap3 Dars2 Ddx28 Dhx30 Ears2 Eral1 Exd2 Fars2 Fastkd2 Gadd45gip1 Gars Gatb Gatc Gfm1 Gfm2 Grsf1 Gtpbp10 Guf1 Hars2 Hemk1 Iars2 Kars Lars2 Lrpprc Malsu1 Mars2 Metap1d Mettl17 Mief1 Mpv17l2 Mrm2 Mrm3 Mrpl1 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Mrpl2 Mrpl20 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Mrpl3 Mrpl30 Mrpl32 Mrpl33 Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrpl4 Mrpl40 Mrpl41 Mrpl42 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl47 Mrpl48 Mrpl49 Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl54 Mrpl55 Mrpl57 Mrpl58 Mrpl9 Mrps10 Mrps11 Mrps12 Mrps14 Mrps15 Mrps16 Mrps17 Mrps18a Mrps18b Mrps18c Mrps2 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrps28 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrps36 Mrps5 Mrps6 Mrps7 Mrps9 Mrrf Mterf1a Mterf3 Mterf4 Mtfmt Mtg1 Mtg2 Mtif2 Mtif3 Mtres1 Mtrf1 Mtrf1l Nars2 Ngrn Noa1 Nsun4 Oxa1l Pars2 Pdf Ppa2 Ptcd3 Pusl1 Qrsl1 Rars2 Rbfa Rmnd1 Sars2 Slirp Taco1 Tars2 Tfb1m Timm21 Tsfm Tufm Vars2 Wars2 Yars2 Ybey
|
||||
Mitochondrial central dogma > Translation > Mitochondrial ribosome MitoCarta3.0 Aurkaip1 Chchd1 Dap3 Gadd45gip1 Mrpl1 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Mrpl2 Mrpl20 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Mrpl3 Mrpl30 Mrpl32 Mrpl33 Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrpl4 Mrpl40 Mrpl41 Mrpl42 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl47 Mrpl48 Mrpl49 Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl54 Mrpl55 Mrpl57 Mrpl58 Mrpl9 Mrps10 Mrps11 Mrps12 Mrps14 Mrps15 Mrps16 Mrps17 Mrps18a Mrps18b Mrps18c Mrps2 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrps28 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrps36 Mrps5 Mrps6 Mrps7 Mrps9 Ptcd3
|
||||
Mitochondrial central dogma > Translation > Mitochondrial ribosome assembly MitoCarta3.0 Ddx28 Dhx30 Eral1 Fastkd2 Grsf1 Gtpbp10 Malsu1 Mettl17 Mief1 Mpv17l2 Mrm2 Mrm3 Mterf1a Mterf3 Mterf4 Mtg1 Mtg2 Ngrn Noa1 Nsun4 Ptcd3 Rbfa Tfb1m Ybey
|
||||
Mitochondrial central dogma > Translation > Translation factors MitoCarta3.0 2810006K23Rik Coa3 Cox14 Gfm1 Gfm2 Hemk1 Mrpl58 Mrrf Mtif2 Mtif3 Mtrf1 Mtrf1l Taco1 Timm21 Tsfm Tufm
|
||||
Mitochondrial central dogma > Translation > mt-tRNA synthetases MitoCarta3.0 Aars2 Cars2 Dars2 Ears2 Fars2 Gars Gatb Gatc Hars2 Iars2 Kars Lars2 Mars2 Nars2 Pars2 Qrsl1 Rars2 Sars2 Tars2 Vars2 Wars2 Yars2
|
||||
Mitochondrial central dogma > Translation > fMet processing MitoCarta3.0 Metap1d Mtfmt Pdf
|
||||
Protein import, sorting and homeostasis MitoCarta3.0 Afg1l Afg3l1 Afg3l2 Agk Aifm1 Atad1 Atp23 Casp3 Casp8 Casp9 Chchd4 Clpb Clpp Clpx Dnaja3 Dnajc11 Dnajc15 Dnajc19 Dnajc4 Dnlz Fkbp10 Gfer Grpel1 Grpel2 Hspd1 Hspe1 Htra2 Ide Immp1l Immp2l Lactb Lap3 Lonp1 Maip1 Metap1d Mipep Mtx1 Mtx2 Mul1 Nln Nrd1 Oma1 Oxa1l Pam16 Park7 Parl Pdf Phb Phb2 Pitrm1 Pmpca Pmpcb Prss35 Romo1 Samm50 Spg7 Stoml2 Timm10 Timm10b Timm13 Timm17a Timm17b Timm21 Timm22 Timm23 Timm29 Timm44 Timm50 Timm8a1 Timm8a2 Timm8b Timm9 Tomm20 Tomm20l Tomm22 Tomm34 Tomm40 Tomm40l Tomm5 Tomm6 Tomm7 Tomm70a Trap1 Uqcrc1 Uqcrc2 Usp30 Xpnpep3 Yme1l1
|
||||
Protein import, sorting and homeostasis > Protein import and sorting MitoCarta3.0 Agk Aifm1 Chchd4 Dnajc11 Dnajc15 Dnajc19 Gfer Grpel1 Grpel2 Immp1l Immp2l Mipep Mtx1 Mtx2 Nrd1 Oxa1l Pam16 Pmpca Pmpcb Romo1 Samm50 Timm10 Timm10b Timm13 Timm17a Timm17b Timm21 Timm22 Timm23 Timm29 Timm44 Timm50 Timm8a1 Timm8a2 Timm8b Timm9 Tomm20 Tomm20l Tomm22 Tomm34 Tomm40 Tomm40l Tomm5 Tomm6 Tomm7 Tomm70a Uqcrc1 Uqcrc2 Xpnpep3
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > TOM MitoCarta3.0 Tomm20 Tomm22 Tomm34 Tomm40 Tomm40l Tomm5 Tomm6 Tomm7 Tomm70a
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > SAM MitoCarta3.0 Mtx1 Mtx2 Samm50
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > MIA40 MitoCarta3.0 Aifm1 Chchd4 Gfer
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > TIM22 carrier pathway MitoCarta3.0 Agk Timm22 Timm29
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > TIM23 presequence pathway MitoCarta3.0 Romo1 Timm17a Timm17b Timm21 Timm23 Timm50
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > Import motor MitoCarta3.0 Dnajc15 Dnajc19 Grpel1 Grpel2 Pam16 Timm44
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > OXA MitoCarta3.0 Oxa1l
|
||||
Protein import, sorting and homeostasis > Protein import and sorting > Preprotein cleavage MitoCarta3.0 Immp1l Immp2l Mipep Pmpca Pmpcb Uqcrc1 Uqcrc2 Xpnpep3
|
||||
Protein import, sorting and homeostasis > Protein homeostasis MitoCarta3.0 Afg1l Afg3l1 Afg3l2 Atad1 Atp23 Casp3 Casp8 Casp9 Clpb Clpp Clpx Dnaja3 Dnajc4 Dnlz Fkbp10 Hspd1 Hspe1 Htra2 Ide Immp1l Immp2l Lactb Lap3 Lonp1 Maip1 Metap1d Mipep Mul1 Nln Nrd1 Oma1 Park7 Parl Pdf Phb Phb2 Pitrm1 Pmpca Pmpcb Prss35 Spg7 Stoml2 Timm10 Timm10b Timm13 Timm8a1 Timm8a2 Timm8b Timm9 Trap1 Usp30 Xpnpep3 Yme1l1
|
||||
Protein import, sorting and homeostasis > Protein homeostasis > Proteases MitoCarta3.0 Afg1l Afg3l1 Afg3l2 Atad1 Atp23 Casp3 Casp9 Clpb Clpp Clpx Htra2 Ide Immp1l Immp2l Lactb Lap3 Lonp1 Metap1d Mipep Nln Oma1 Parl Pitrm1 Pmpca Pmpcb Spg7 Usp30 Xpnpep3 Yme1l1
|
||||
Protein import, sorting and homeostasis > Protein homeostasis > Chaperones MitoCarta3.0 Dnaja3 Dnlz Fkbp10 Hspd1 Hspe1 Maip1 Nrd1 Phb Phb2 Timm10 Timm10b Timm13 Timm8a1 Timm8a2 Timm8b Timm9 Trap1
|
||||
OXPHOS MitoCarta3.0 Acad9 Aifm1 Atp5a1 Atp5b Atp5c1 Atp5d Atp5e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5j Atp5j2 Atp5k Atp5l Atp5md Atp5mpl Atp5o Atp5pb Atpaf1 Atpaf2 Atpif1 Atpsckmt Bcs1l Cep89 Cmc1 Cmc2 Coa3 Coa4 Coa5 Coa6 Coa7 Coa8 Cox10 Cox11 Cox14 Cox15 Cox16 Cox17 Cox18 Cox19 Cox20 Cox4i1 Cox4i2 Cox5a Cox5b Cox6a1 Cox6a2 Cox6b1 Cox6b2 Cox6c Cox7a1 Cox7a2 Cox7a2l Cox7b Cox7c Cox8a Cox8b Cox8c Cyc1 Cycs Cyct Dmac1 Dmac2 Dmac2l Ecsit Fmc1 Foxred1 Hccs Higd1a Higd2a Lyrm2 Lyrm7 Ndufa1 Ndufa10 Ndufa11 Ndufa12 Ndufa13 Ndufa2 Ndufa3 Ndufa4 Ndufa5 Ndufa6 Ndufa7 Ndufa8 Ndufa9 Ndufab1 Ndufaf1 Ndufaf2 Ndufaf3 Ndufaf4 Ndufaf5 Ndufaf6 Ndufaf7 Ndufaf8 Ndufb10 Ndufb11 Ndufb2 Ndufb3 Ndufb4 Ndufb5 Ndufb6 Ndufb7 Ndufb8 Ndufb9 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs3 Ndufs4 Ndufs5 Ndufs6 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Ndufv3 Nubpl Pet100 Pet117 Pnkd Rab5if Sco1 Sco2 Sdha Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4 Sdhb Sdhc Sdhd Smim20 Surf1 Taco1 Timm21 Timmdc1 Tmem126a Tmem126b Tmem177 Tmem186 Tmem70 Ttc19 Uqcc1 Uqcc2 Uqcc3 Uqcr10 Uqcr11 Uqcrb Uqcrc1 Uqcrc2 Uqcrfs1 Uqcrh Uqcrq mt-Atp6 mt-Atp8 mt-Co1 mt-Co2 mt-Co3 mt-Cytb mt-Nd1 mt-Nd2 mt-Nd3 mt-Nd4 mt-Nd4l mt-Nd5 mt-Nd6
|
||||
OXPHOS > OXPHOS subunits MitoCarta3.0 Atp5a1 Atp5b Atp5c1 Atp5d Atp5e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5j Atp5j2 Atp5k Atp5l Atp5md Atp5mpl Atp5o Atp5pb Atpif1 Cox4i1 Cox4i2 Cox5a Cox5b Cox6a1 Cox6a2 Cox6b1 Cox6b2 Cox6c Cox7a1 Cox7a2 Cox7a2l Cox7b Cox7c Cox8a Cox8b Cox8c Cyc1 Cycs Cyct Dmac2l Hccs Ndufa1 Ndufa10 Ndufa11 Ndufa12 Ndufa13 Ndufa2 Ndufa3 Ndufa4 Ndufa5 Ndufa6 Ndufa7 Ndufa8 Ndufa9 Ndufab1 Ndufb10 Ndufb11 Ndufb2 Ndufb3 Ndufb4 Ndufb5 Ndufb6 Ndufb7 Ndufb8 Ndufb9 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs3 Ndufs4 Ndufs5 Ndufs6 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Ndufv3 Sdha Sdhb Sdhc Sdhd Uqcr10 Uqcr11 Uqcrb Uqcrc1 Uqcrc2 Uqcrfs1 Uqcrh Uqcrq mt-Atp6 mt-Atp8 mt-Co1 mt-Co2 mt-Co3 mt-Cytb mt-Nd1 mt-Nd2 mt-Nd3 mt-Nd4 mt-Nd4l mt-Nd5 mt-Nd6
|
||||
OXPHOS > OXPHOS assembly factors MitoCarta3.0 Acad9 Aifm1 Atpaf1 Atpaf2 Atpsckmt Bcs1l Cep89 Cmc1 Cmc2 Coa3 Coa4 Coa5 Coa6 Coa7 Coa8 Cox10 Cox11 Cox14 Cox15 Cox16 Cox17 Cox18 Cox19 Cox20 Cox7a2l Dmac1 Dmac2 Ecsit Fmc1 Foxred1 Higd1a Higd2a Lyrm2 Lyrm7 Ndufaf1 Ndufaf2 Ndufaf3 Ndufaf4 Ndufaf5 Ndufaf6 Ndufaf7 Ndufaf8 Nubpl Pet100 Pet117 Pnkd Rab5if Sco1 Sco2 Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4 Smim20 Surf1 Taco1 Timm21 Timmdc1 Tmem126a Tmem126b Tmem177 Tmem186 Tmem70 Ttc19 Uqcc1 Uqcc2 Uqcc3
|
||||
OXPHOS > Complex I MitoCarta3.0 Acad9 Aifm1 Dmac1 Dmac2 Ecsit Foxred1 Lyrm2 Ndufa1 Ndufa10 Ndufa11 Ndufa12 Ndufa13 Ndufa2 Ndufa3 Ndufa5 Ndufa6 Ndufa7 Ndufa8 Ndufa9 Ndufab1 Ndufaf1 Ndufaf2 Ndufaf3 Ndufaf4 Ndufaf5 Ndufaf6 Ndufaf7 Ndufaf8 Ndufb10 Ndufb11 Ndufb2 Ndufb3 Ndufb4 Ndufb5 Ndufb6 Ndufb7 Ndufb8 Ndufb9 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs3 Ndufs4 Ndufs5 Ndufs6 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Ndufv3 Nubpl Timmdc1 Tmem126a Tmem126b Tmem186 Tmem70 mt-Nd1 mt-Nd2 mt-Nd3 mt-Nd4 mt-Nd4l mt-Nd5 mt-Nd6
|
||||
OXPHOS > Complex I > CI subunits MitoCarta3.0 Ndufa1 Ndufa10 Ndufa11 Ndufa12 Ndufa13 Ndufa2 Ndufa3 Ndufa5 Ndufa6 Ndufa7 Ndufa8 Ndufa9 Ndufab1 Ndufb10 Ndufb11 Ndufb2 Ndufb3 Ndufb4 Ndufb5 Ndufb6 Ndufb7 Ndufb8 Ndufb9 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs3 Ndufs4 Ndufs5 Ndufs6 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Ndufv3 mt-Nd1 mt-Nd2 mt-Nd3 mt-Nd4 mt-Nd4l mt-Nd5 mt-Nd6
|
||||
OXPHOS > Complex I > CI assembly factors MitoCarta3.0 Acad9 Aifm1 Dmac1 Dmac2 Ecsit Foxred1 Lyrm2 Ndufaf1 Ndufaf2 Ndufaf3 Ndufaf4 Ndufaf5 Ndufaf6 Ndufaf7 Ndufaf8 Nubpl Timmdc1 Tmem126a Tmem126b Tmem186 Tmem70
|
||||
OXPHOS > Complex II MitoCarta3.0 Sdha Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4 Sdhb Sdhc Sdhd
|
||||
OXPHOS > Complex II > CII subunits MitoCarta3.0 Sdha Sdhb Sdhc Sdhd
|
||||
OXPHOS > Complex II > CII assembly factors MitoCarta3.0 Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4
|
||||
OXPHOS > Complex III MitoCarta3.0 Bcs1l Cyc1 Lyrm7 Ttc19 Uqcc1 Uqcc2 Uqcc3 Uqcr10 Uqcr11 Uqcrb Uqcrc1 Uqcrc2 Uqcrfs1 Uqcrh Uqcrq mt-Cytb
|
||||
OXPHOS > Complex III > CIII subunits MitoCarta3.0 Cyc1 Uqcr10 Uqcr11 Uqcrb Uqcrc1 Uqcrc2 Uqcrfs1 Uqcrh Uqcrq mt-Cytb
|
||||
OXPHOS > Complex III > CIII assembly factors MitoCarta3.0 Bcs1l Lyrm7 Ttc19 Uqcc1 Uqcc2 Uqcc3
|
||||
OXPHOS > Complex IV MitoCarta3.0 Cep89 Cmc1 Cmc2 Coa3 Coa4 Coa5 Coa6 Coa7 Coa8 Cox10 Cox11 Cox14 Cox15 Cox16 Cox17 Cox18 Cox19 Cox20 Cox4i1 Cox4i2 Cox5a Cox5b Cox6a1 Cox6a2 Cox6b1 Cox6b2 Cox6c Cox7a1 Cox7a2 Cox7a2l Cox7b Cox7c Cox8a Cox8b Cox8c Higd1a Ndufa4 Pet100 Pet117 Pnkd Sco1 Sco2 Smim20 Surf1 Taco1 Timm21 Tmem177 mt-Co1 mt-Co2 mt-Co3
|
||||
OXPHOS > Complex IV > CIV subunits MitoCarta3.0 Cox4i1 Cox4i2 Cox5a Cox5b Cox6a1 Cox6a2 Cox6b1 Cox6b2 Cox6c Cox7a1 Cox7a2 Cox7a2l Cox7b Cox7c Cox8a Cox8b Cox8c Ndufa4 mt-Co1 mt-Co2 mt-Co3
|
||||
OXPHOS > Complex IV > CIV assembly factors MitoCarta3.0 Cep89 Cmc1 Cmc2 Coa3 Coa4 Coa5 Coa6 Coa7 Coa8 Cox10 Cox11 Cox14 Cox15 Cox16 Cox17 Cox18 Cox19 Cox20 Higd1a Pet100 Pet117 Pnkd Sco1 Sco2 Smim20 Surf1 Taco1 Timm21 Tmem177
|
||||
OXPHOS > Complex V MitoCarta3.0 Atp5a1 Atp5b Atp5c1 Atp5d Atp5e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5j Atp5j2 Atp5k Atp5l Atp5md Atp5mpl Atp5o Atp5pb Atpaf1 Atpaf2 Atpif1 Atpsckmt Dmac2l Fmc1 Tmem70 mt-Atp6 mt-Atp8
|
||||
OXPHOS > Complex V > CV subunits MitoCarta3.0 Atp5a1 Atp5b Atp5c1 Atp5d Atp5e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5j Atp5j2 Atp5k Atp5l Atp5md Atp5mpl Atp5o Atp5pb Atpif1 Dmac2l mt-Atp6 mt-Atp8
|
||||
OXPHOS > Complex V > CV assembly factors MitoCarta3.0 Atpaf1 Atpaf2 Atpsckmt Fmc1 Tmem70
|
||||
OXPHOS > Respirasome assembly MitoCarta3.0 Cox7a2l Higd1a Higd2a Rab5if
|
||||
OXPHOS > Cytochrome C MitoCarta3.0 Cycs Cyct Hccs
|
||||
Metabolism MitoCarta3.0 Aadat Aass Abat Abcb10 Abcb6 Abcb7 Abhd10 Abhd11 Acaa1a Acaa1b Acaa2 Acaca Acacb Acad10 Acad11 Acad12 Acad8 Acadl Acadm Acads Acadsb Acadvl Acat1 Acly Aco2 Acod1 Acot10 Acot11 Acot13 Acot2 Acot7 Acot9 Acp6 Acsf2 Acsf3 Acsl1 Acsl6 Acsm1 Acsm2 Acsm3 Acsm4 Acsm5 Acss1 Acss3 Adhfe1 Agk Agmat Agpat4 Agpat5 Agxt Agxt2 Aifm2 Aifm3 Ak2 Ak3 Ak4 Akr1b10 Akr1b7 Akr7a5 Alas1 Alas2 Aldh18a1 Aldh1b1 Aldh1l1 Aldh1l2 Aldh2 Aldh3a2 Aldh4a1 Aldh5a1 Aldh6a1 Aldh7a1 Aldh9a1 Amacr Amt Antkmt Arg2 Auh Bcat2 Bckdha Bckdhb Bckdk Bco2 Bdh1 Bola1 Bola3 Bphl Car5a Car5b Cat Cbr2 Cbr3 Cbr4 Chchd7 Chdh Chpt1 Cisd1 Cisd3 Ckmt1 Ckmt2 Clybl Cmpk2 Coasy Comt Coq10a Coq10b Coq2 Coq3 Coq4 Coq5 Coq6 Coq7 Coq8a Coq8b Coq9 Cox10 Cox11 Cox15 Cox17 Cox19 Cpox Cps1 Cpt1a Cpt1b Cpt1c Cpt2 Crat Crls1 Crot Cs Cyb5b Cyb5r3 Cyc1 Cycs Cyct Cyp11a1 Cyp11b1 Cyp11b2 Cyp24a1 Cyp27a1 Cyp27b1 D2hgdh Dbi Dbt Dcxr Decr1 Dglucy Dguok Dhodh Dhrs1 Dhrs2 Dhrs4 Dhtkd1 Dlat Dld Dlst Dmgdh Dna2 Dut Ech1 Echdc1 Echs1 Eci1 Eci2 Ehhadh Ephx2 Etfa Etfb Etfbkmt Etfdh Etfrf1 Ethe1 Fabp1 Fahd1 Fam210b Fasn Fdps Fdx1 Fdx2 Fdxr Fech Fh1 Fhit Flad1 Fpgs Fth1 Ftmt Fxn Gatm Gcat Gcdh Gcsh Gldc Glrx2 Glrx5 Gls Gls2 Glud1 Glyat Glyctk Gm4952 Gm4984 Got2 Gpam Gpat2 Gpd2 Gpt2 Gpx1 Gpx4 Grhpr Grpel1 Grpel2 Gsr Gstk1 Gstz1 Gtpbp3 Guk1 H2-Ke6 Hadh Hadha Hadhb Hagh Hao2 Hccs Hibadh Hibch Hint1 Hint2 Hmgcl Hmgcs2 Hoga1 Hscb Hsd17b10 Hsd17b4 Hspa9 Htd2 Iba57 Idh2 Idh3a Idh3b Idh3g Idi1 Isca1 Isca2 Iscu Ivd Kmo Kyat3 L2hgdh Lactb Ldhal6b Ldhb Ldhd Lias Lipt1 Lipt2 Lypla1 Lyplal1 Lyrm4 Maoa Maob Mcat Mccc1 Mccc2 Mcee Mdh2 Me2 Me3 Mecr Mgst1 Mgst3 Mlycd Mmaa Mmab Mmadhc Mmut Mocs1 Mpc1 Mpc2 Mpst Mrps36 Msra Msrb2 Msrb3 Mtarc1 Mtarc2 Mtfmt Mthfd1l Mthfd2 Mthfd2l Mthfs Mthfsl Mto1 Nadk2 Nags Nat8l Naxd Naxe Ndufab1 Ndufs1 Ndufs2 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Neu4 Nfs1 Nfu1 Nit1 Nit2 Nme3 Nme4 Nme6 Nmnat3 Nnt Noct Nt5dc2 Nt5m Nthl1 Nubpl Nudt13 Nudt19 Nudt2 Nudt5 Nudt8 Nudt9 Oat Ogdh Ogdhl Osbpl1a Otc Oxct1 Oxct2a Oxr1 Oxsm Paics Pank2 Pcbd2 Pcca Pccb Pck2 Pcx Pdha1 Pdha2 Pdhb Pdhx Pdk1 Pdk2 Pdk3 Pdk4 Pdp1 Pdp2 Pdpr Pdss1 Pdss2 Pgs1 Phyh Pisd Pld6 Plpbp Plscr3 Pnpla8 Pnpo Ppa2 Ppm1k Ppox Prdx2 Prdx3 Prdx4 Prdx5 Prdx6 Prelid1 Prelid3a Prelid3b Prodh Prodh2 Prxl2a Ptges2 Ptpmt1 Pycr1 Pycr2 Qdpr Rdh13 Rdh14 Rfk Rpia Rsad1 Sardh Sco1 Sco2 Scp2 Sdha Sdhb Sdhc Sdhd Sdsl Selenoo Serac1 Sfxn1 Sfxn3 Sfxn5 Shmt2 Sirt3 Sirt4 Sirt5 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a19 Slc25a2 Slc25a20 Slc25a21 Slc25a23 Slc25a24 Slc25a25 Slc25a28 Slc25a29 Slc25a3 Slc25a30 Slc25a31 Slc25a32 Slc25a33 Slc25a36 Slc25a37 Slc25a38 Slc25a4 Slc25a41 Slc25a42 Slc25a44 Slc25a5 Slc25a51 Sod1 Sod2 Sphk2 Spr Sptlc2 Sqor Star Stard7 Sucla2 Suclg1 Suclg2 Sugct Suox Tamm41 Taz Them4 Them5 Tk2 Tmlhe Triap1 Tspo Tst Tstd1 Txn2 Txnrd1 Txnrd2 Uqcrfs1 Zadh2 mt-Co1 mt-Cytb
|
||||
Metabolism > Carbohydrate metabolism MitoCarta3.0 Abhd11 Acaa2 Acat1 Acly Aco2 Acod1 Auh Bdh1 Clybl Cs D2hgdh Dcxr Dlat Dld Dlst Fahd1 Fh1 Glyctk Gm4984 Got2 Gpd2 Hadhb Hmgcl Hmgcs2 Idh2 Idh3a Idh3b Idh3g L2hgdh Ldhal6b Ldhd Mcee Mdh2 Me2 Me3 Mmut Mpc1 Mpc2 Mrps36 Neu4 Ogdh Ogdhl Oxct1 Oxct2a Pcca Pccb Pck2 Pcx Pdha1 Pdha2 Pdhb Pdhx Pdk1 Pdk2 Pdk3 Pdk4 Pdp1 Pdp2 Pdpr Rpia Sdha Sdhb Sdhc Sdhd Sfxn5 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Sucla2 Suclg1 Suclg2
|
||||
Metabolism > Carbohydrate metabolism > Gluconeogenesis MitoCarta3.0 Gm4984 Mdh2 Mpc1 Mpc2 Pck2 Pcx Slc25a1 Slc25a10 Slc25a11
|
||||
Metabolism > Carbohydrate metabolism > Malate-aspartate shuttle MitoCarta3.0 Got2 Mdh2 Slc25a10 Slc25a11 Slc25a12 Slc25a13
|
||||
Metabolism > Carbohydrate metabolism > Glycerol phosphate shuttle MitoCarta3.0 Gpd2
|
||||
Metabolism > Carbohydrate metabolism > Pyruvate metabolism MitoCarta3.0 Dlat Dld Gm4984 Mpc1 Mpc2 Pdha1 Pdha2 Pdhb Pdhx Pdk1 Pdk2 Pdk3 Pdk4 Pdp1 Pdp2 Pdpr
|
||||
Metabolism > Carbohydrate metabolism > TCA cycle MitoCarta3.0 Aco2 Cs Dld Dlst Fh1 Idh2 Idh3a Idh3b Idh3g Mdh2 Mrps36 Ogdh Ogdhl Sdha Sdhb Sdhc Sdhd Sucla2 Suclg1 Suclg2
|
||||
Metabolism > Carbohydrate metabolism > TCA-associated MitoCarta3.0 Abhd11 Acly D2hgdh Fahd1 Gm4984 L2hgdh Me2 Me3 Mpc1 Mpc2 Pck2 Pcx Sfxn5 Slc25a1 Slc25a11
|
||||
Metabolism > Carbohydrate metabolism > Itaconate metabolism MitoCarta3.0 Acod1 Auh Clybl Sucla2 Suclg1 Suclg2
|
||||
Metabolism > Carbohydrate metabolism > Ketone metabolism MitoCarta3.0 Acaa2 Acat1 Bdh1 Hadhb Hmgcl Hmgcs2 Oxct1 Oxct2a
|
||||
Metabolism > Carbohydrate metabolism > Propanoate metabolism MitoCarta3.0 Mcee Mmut Pcca Pccb
|
||||
Metabolism > Lipid metabolism MitoCarta3.0 Acaa1a Acaa1b Acaa2 Acaca Acacb Acad10 Acad11 Acad12 Acadl Acadm Acads Acadsb Acadvl Acat1 Acot10 Acot11 Acot13 Acot2 Acot7 Acot9 Acp6 Acsf2 Acsf3 Acsl1 Acsl6 Acsm1 Acsm2 Acsm3 Acsm4 Acsm5 Acss1 Acss3 Agk Agpat4 Agpat5 Akr1b7 Amacr Cbr4 Chpt1 Cpt1a Cpt1b Cpt1c Cpt2 Crat Crls1 Crot Cyb5r3 Cyp11a1 Cyp11b1 Cyp11b2 Cyp27a1 Dbi Decr1 Dhrs1 Ech1 Echdc1 Echs1 Eci1 Eci2 Ehhadh Ephx2 Etfa Etfb Etfdh Fabp1 Fasn Fdps Fdx1 Fdxr Gcsh Gpam Gpat2 H2-Ke6 Hadh Hadha Hadhb Hao2 Hint2 Hsd17b10 Hsd17b4 Htd2 Idi1 Lactb Lias Lipt1 Lipt2 Lypla1 Lyplal1 Mcat Mcee Mecr Mgst3 Mlycd Mmut Ndufab1 Osbpl1a Oxsm Pcca Pccb Pgs1 Phyh Pisd Pld6 Plscr3 Pnpla8 Prdx6 Prelid1 Prelid3a Prelid3b Ptges2 Ptpmt1 Scp2 Serac1 Slc25a1 Slc25a20 Sphk2 Sptlc2 Star Stard7 Tamm41 Taz Them4 Them5 Triap1 Tspo Zadh2
|
||||
Metabolism > Lipid metabolism > Fatty acid oxidation MitoCarta3.0 Acaa1a Acaa2 Acacb Acad10 Acad11 Acad12 Acadl Acadm Acads Acadsb Acadvl Acat1 Acot11 Acsf2 Acsl1 Acsl6 Acsm1 Acsm2 Acsm3 Acsm4 Acsm5 Acss1 Amacr Cpt1a Cpt1b Cpt1c Cpt2 Crat Crot Decr1 Echs1 Eci1 Eci2 Etfa Etfb Etfdh Hadh Hadha Hadhb Hsd17b10 Mcee Mmut Pcca Pccb Slc25a20
|
||||
Metabolism > Lipid metabolism > Type II fatty acid synthesis MitoCarta3.0 Acaca Acsf3 Cbr4 H2-Ke6 Htd2 Mcat Mecr Ndufab1 Oxsm
|
||||
Metabolism > Lipid metabolism > Lipoate insertion MitoCarta3.0 Gcsh Lias Lipt1 Lipt2
|
||||
Metabolism > Lipid metabolism > Cardiolipin synthesis MitoCarta3.0 Agpat4 Agpat5 Crls1 Gpam Gpat2 Hadha Pgs1 Pld6 Plscr3 Pnpla8 Prelid1 Prelid3a Ptpmt1 Tamm41 Taz Triap1
|
||||
Metabolism > Lipid metabolism > Cholesterol, bile acid, steroid synthesis MitoCarta3.0 Cyp11a1 Cyp11b1 Cyp11b2 Cyp27a1 Dhrs1 Fdx1 Fdxr H2-Ke6 Hint2 Hsd17b10 Osbpl1a Scp2 Star Tspo
|
||||
Metabolism > Lipid metabolism > Cholesterol-associated MitoCarta3.0 Fdps Idi1
|
||||
Metabolism > Lipid metabolism > Phospholipid metabolism MitoCarta3.0 Acp6 Agk Agpat4 Agpat5 Akr1b7 Chpt1 Gpam Gpat2 Lactb Osbpl1a Pgs1 Pisd Pnpla8 Prdx6 Prelid1 Prelid3a Prelid3b Ptpmt1 Serac1 Sphk2 Sptlc2 Stard7 Tamm41 Triap1
|
||||
Metabolism > Lipid metabolism > Eicosanoid metabolism MitoCarta3.0 Mgst3 Ptges2 Zadh2
|
||||
Metabolism > Amino acid metabolism MitoCarta3.0 Aadat Aass Abat Acaa2 Acad8 Acadsb Acat1 Adhfe1 Agmat Agxt Agxt2 Akr7a5 Aldh18a1 Aldh4a1 Aldh5a1 Aldh6a1 Aldh7a1 Aldh9a1 Amt Arg2 Auh Bcat2 Bckdha Bckdhb Bckdk Car5a Car5b Chdh Comt Cps1 Dbt Dglucy Dhtkd1 Dld Dlst Dmgdh Echs1 Etfa Etfb Etfdh Gcat Gcdh Gcsh Gldc Gls Gls2 Glud1 Glyat Got2 Gpt2 Grhpr Hadh Hadha Hadhb Hibadh Hibch Hmgcl Hoga1 Hsd17b10 Ivd Kmo Kyat3 Ldhb Maoa Maob Mccc1 Mccc2 Nags Nat8l Oat Otc Ppm1k Prodh Prodh2 Pycr1 Pycr2 Sardh Sdsl Sfxn1 Sfxn3 Shmt2 Slc25a12 Slc25a13 Slc25a15 Slc25a2 Slc25a21 Slc25a29 Slc25a38 Slc25a44 Sugct
|
||||
Metabolism > Amino acid metabolism > Branched-chain amino acid metabolism MitoCarta3.0 Acad8 Acadsb Acat1 Aldh6a1 Auh Bcat2 Bckdha Bckdhb Bckdk Dbt Dld Echs1 Etfa Etfb Etfdh Hadha Hibadh Hibch Hmgcl Hsd17b10 Ivd Mccc1 Mccc2 Ppm1k Slc25a44
|
||||
Metabolism > Amino acid metabolism > Branched-chain amino acid dehydrogenase complex MitoCarta3.0 Bckdha Bckdhb Bckdk Dbt Dld Ppm1k
|
||||
Metabolism > Amino acid metabolism > Lysine metabolism MitoCarta3.0 Aadat Aass Acaa2 Acat1 Aldh7a1 Dhtkd1 Dld Dlst Echs1 Etfa Etfb Etfdh Gcdh Hadh Hadhb Slc25a29
|
||||
Metabolism > Amino acid metabolism > Serine metabolism MitoCarta3.0 Agxt Sdsl Sfxn1 Sfxn3 Shmt2
|
||||
Metabolism > Amino acid metabolism > Glycine metabolism MitoCarta3.0 Aldh7a1 Amt Chdh Dld Dmgdh Etfa Etfb Etfdh Gcat Gcsh Gldc Glyat Sardh Shmt2 Slc25a38
|
||||
Metabolism > Amino acid metabolism > Glycine cleavage system MitoCarta3.0 Amt Dld Gcsh Gldc
|
||||
Metabolism > Amino acid metabolism > Glutamate metabolism MitoCarta3.0 Gls Gls2 Glud1 Got2 Gpt2 Nat8l Slc25a12
|
||||
Metabolism > Amino acid metabolism > Proline metabolism MitoCarta3.0 Aldh18a1 Aldh4a1 Oat Prodh Pycr1 Pycr2
|
||||
Metabolism > Amino acid metabolism > Glyoxylate metabolism MitoCarta3.0 Agxt Agxt2 Aldh4a1 Got2 Grhpr Hoga1 Ldhb Prodh2
|
||||
Metabolism > Amino acid metabolism > GABA metabolism MitoCarta3.0 Abat Adhfe1 Akr7a5 Aldh5a1 Aldh9a1 Glud1
|
||||
Metabolism > Amino acid metabolism > Catechol metabolism MitoCarta3.0 Comt Maoa Maob
|
||||
Metabolism > Amino acid metabolism > Kynurenine metabolism MitoCarta3.0 Got2 Kmo Kyat3
|
||||
Metabolism > Amino acid metabolism > Urea cycle MitoCarta3.0 Car5a Car5b Cps1 Nags Otc Slc25a13 Slc25a15 Slc25a2
|
||||
Metabolism > Nucleotide metabolism MitoCarta3.0 Ak2 Ak3 Ak4 Antkmt Ckmt1 Ckmt2 Cmpk2 Dguok Dhodh Dut Fhit Gatm Guk1 Hint1 Nme3 Nme4 Nme6 Nt5dc2 Nt5m Nudt2 Nudt5 Nudt9 Paics Ppa2 Slc25a23 Slc25a24 Slc25a25 Slc25a31 Slc25a33 Slc25a36 Slc25a4 Slc25a41 Slc25a5 Sucla2 Suclg1 Tk2
|
||||
Metabolism > Nucleotide metabolism > Nucleotide import MitoCarta3.0 Slc25a23 Slc25a24 Slc25a25 Slc25a31 Slc25a33 Slc25a36 Slc25a4 Slc25a41 Slc25a5
|
||||
Metabolism > Nucleotide metabolism > Nucleotide synthesis and processing MitoCarta3.0 Ak2 Ak3 Ak4 Cmpk2 Dguok Dhodh Dut Fhit Guk1 Hint1 Nme3 Nme4 Nme6 Nt5dc2 Nt5m Nudt2 Nudt5 Nudt9 Paics Sucla2 Suclg1 Tk2
|
||||
Metabolism > Nucleotide metabolism > Creatine metabolism MitoCarta3.0 Ckmt1 Ckmt2 Gatm
|
||||
Metabolism > Metals and cofactors MitoCarta3.0 Abat Abcb10 Abcb6 Abcb7 Aco2 Aifm3 Alas1 Alas2 Bola1 Bola3 Chchd7 Cisd1 Cisd3 Coasy Coq10a Coq10b Coq2 Coq3 Coq4 Coq5 Coq6 Coq7 Coq8a Coq8b Coq9 Cox10 Cox11 Cox15 Cox17 Cox19 Cpox Cpt1a Cpt1b Cpt1c Cpt2 Cyb5b Cyc1 Cycs Cyp11a1 Cyp11b2 Cyp24a1 Cyp27a1 Cyp27b1 Dna2 Etfdh Fabp1 Fam210b Fdx1 Fdx2 Fdxr Fech Fth1 Ftmt Fxn Glrx2 Glrx5 Grpel1 Grpel2 Hccs Hscb Hspa9 Iba57 Isca1 Isca2 Iscu Kmo Kyat3 Lias Lyrm4 Mocs1 Mtarc1 Mtarc2 Nadk2 Naxd Naxe Ndufab1 Ndufs1 Ndufs2 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Nfs1 Nfu1 Nmnat3 Nnt Noct Nthl1 Nubpl Nudt13 Nudt19 Nudt8 Pank2 Pcbd2 Pdss1 Pdss2 Ppox Qdpr Rsad1 Sco1 Sco2 Sdhb Sdhc Sdhd Sirt3 Sirt4 Sirt5 Slc25a20 Slc25a28 Slc25a3 Slc25a37 Slc25a38 Slc25a42 Slc25a51 Spr Suox Tmlhe Uqcrfs1 mt-Co1 mt-Cytb
|
||||
Metabolism > Metals and cofactors > Carnitine synthesis and transport MitoCarta3.0 Cpt1a Cpt1b Cpt1c Cpt2 Slc25a20 Tmlhe
|
||||
Metabolism > Metals and cofactors > Carnitine shuttle MitoCarta3.0 Cpt1a Cpt1b Cpt1c Cpt2 Slc25a20
|
||||
Metabolism > Metals and cofactors > Coenzyme A metabolism MitoCarta3.0 Coasy Nudt19 Nudt8 Pank2 Slc25a42
|
||||
Metabolism > Metals and cofactors > Coenzyme Q metabolism MitoCarta3.0 Coq10a Coq10b Coq2 Coq3 Coq4 Coq5 Coq6 Coq7 Coq8a Coq8b Coq9 Pdss1 Pdss2
|
||||
Metabolism > Metals and cofactors > Copper metabolism MitoCarta3.0 Chchd7 Cox11 Cox17 Cox19 Sco1 Sco2 Slc25a3
|
||||
Metabolism > Metals and cofactors > Iron homeostasis MitoCarta3.0 Fam210b Fth1 Ftmt Slc25a28 Slc25a37
|
||||
Metabolism > Metals and cofactors > Heme synthesis and processing MitoCarta3.0 Abcb10 Abcb6 Abcb7 Alas1 Alas2 Cox10 Cox15 Cpox Fabp1 Fdx1 Fdx2 Fdxr Fech Hccs Ppox Slc25a38
|
||||
Metabolism > Metals and cofactors > Fe-S cluster biosynthesis MitoCarta3.0 Abcb7 Bola1 Bola3 Cisd1 Cisd3 Fdx1 Fdx2 Fdxr Fxn Glrx5 Grpel1 Grpel2 Hscb Hspa9 Iba57 Isca1 Isca2 Iscu Lyrm4 Ndufab1 Nfs1 Nfu1 Nubpl
|
||||
Metabolism > Metals and cofactors > Molybdenum cofactor synthesis and proteins MitoCarta3.0 Abcb7 Mocs1 Mtarc1 Mtarc2 Suox
|
||||
Metabolism > Metals and cofactors > NAD biosynthesis and metabolism MitoCarta3.0 Kmo Kyat3 Nadk2 Naxd Naxe Nmnat3 Nnt Noct Nudt13 Sirt3 Sirt4 Sirt5 Slc25a51
|
||||
Metabolism > Metals and cofactors > Tetrahydrobiopterin synthesis MitoCarta3.0 Pcbd2 Qdpr Spr
|
||||
Metabolism > Metals and cofactors > Fe-S-containing proteins MitoCarta3.0 Abat Aco2 Aifm3 Bola1 Bola3 Cisd1 Cisd3 Dna2 Etfdh Fdx1 Fdx2 Fech Glrx2 Glrx5 Isca1 Isca2 Iscu Lias Ndufs1 Ndufs2 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Nfs1 Nfu1 Nthl1 Nubpl Rsad1 Sdhb Uqcrfs1
|
||||
Metabolism > Metals and cofactors > Heme-containing proteins MitoCarta3.0 Cyb5b Cyc1 Cycs Cyp11a1 Cyp11b2 Cyp24a1 Cyp27a1 Cyp27b1 Sdhc Sdhd mt-Co1 mt-Cytb
|
||||
Metabolism > Vitamin metabolism MitoCarta3.0 Acaca Acacb Akr1b10 Aldh1l1 Aldh1l2 Aldh7a1 Amt Bco2 Chdh Cyp24a1 Cyp27b1 Dhrs4 Dmgdh Etfa Etfb Etfdh Fdx1 Fdxr Flad1 Fpgs Glrx2 Gtpbp3 Mccc1 Mmaa Mmab Mmadhc Mmut Mtfmt Mthfd1l Mthfd2 Mthfd2l Mthfs Mthfsl Mto1 Pcca Pcx Plpbp Pnpo Qdpr Rdh13 Rdh14 Rfk Sardh Sfxn1 Sfxn3 Shmt2 Slc25a19 Slc25a32 Slc25a38 Txn2
|
||||
Metabolism > Vitamin metabolism > Choline and betaine metabolism MitoCarta3.0 Aldh7a1 Chdh Dmgdh Etfa Etfb Etfdh Sardh
|
||||
Metabolism > Vitamin metabolism > Biotin utilizing proteins MitoCarta3.0 Acaca Acacb Mccc1 Pcca Pcx
|
||||
Metabolism > Vitamin metabolism > Vitamin A metabolism MitoCarta3.0 Akr1b10 Bco2 Dhrs4 Rdh13 Rdh14
|
||||
Metabolism > Vitamin metabolism > Vitamin B1 metabolism MitoCarta3.0 Slc25a19
|
||||
Metabolism > Vitamin metabolism > Vitamin B2 metabolism MitoCarta3.0 Flad1 Rfk Slc25a32
|
||||
Metabolism > Vitamin metabolism > Vitamin B6 metabolism MitoCarta3.0 Plpbp Pnpo
|
||||
Metabolism > Vitamin metabolism > Vitamin B12 metabolism MitoCarta3.0 Mmaa Mmab Mmadhc Mmut
|
||||
Metabolism > Vitamin metabolism > Vitamin C metabolism MitoCarta3.0 Glrx2 Txn2
|
||||
Metabolism > Vitamin metabolism > Vitamin D metabolism MitoCarta3.0 Cyp24a1 Cyp27b1 Fdx1 Fdxr
|
||||
Metabolism > Vitamin metabolism > Folate and 1-C metabolism MitoCarta3.0 Aldh1l1 Aldh1l2 Aldh7a1 Amt Chdh Dmgdh Fpgs Gtpbp3 Mtfmt Mthfd1l Mthfd2 Mthfd2l Mthfs Mthfsl Mto1 Qdpr Sardh Sfxn1 Sfxn3 Shmt2 Slc25a32 Slc25a38
|
||||
Metabolism > Detoxification MitoCarta3.0 Abhd10 Acsm2 Acsm5 Aifm2 Akr1b10 Akr7a5 Aldh1b1 Aldh2 Aldh3a2 Aldh7a1 Aldh9a1 Bphl Cat Cbr3 Cyb5b Cyb5r3 Dhrs2 Ephx2 Glrx2 Glyat Gpx1 Gpx4 Gsr Gstk1 Gstz1 Hagh Maoa Maob Mgst1 Mpst Msra Msrb2 Msrb3 Mtarc1 Mtarc2 Nit1 Nit2 Oxr1 Prdx2 Prdx3 Prdx4 Prdx5 Prdx6 Prxl2a Selenoo Sod1 Sod2 Tst Txn2 Txnrd1 Txnrd2
|
||||
Metabolism > Detoxification > Xenobiotic metabolism MitoCarta3.0 Abhd10 Acsm2 Acsm5 Akr1b10 Akr7a5 Aldh1b1 Aldh2 Bphl Cbr3 Cyb5b Cyb5r3 Dhrs2 Ephx2 Glyat Gstk1 Gstz1 Maoa Maob Mgst1 Mpst Mtarc1 Mtarc2 Tst
|
||||
Metabolism > Detoxification > ROS and glutathione metabolism MitoCarta3.0 Aifm2 Aldh3a2 Aldh7a1 Aldh9a1 Cat Glrx2 Gpx1 Gpx4 Gsr Hagh Mgst1 Msra Msrb2 Msrb3 Nit1 Oxr1 Prdx2 Prdx3 Prdx4 Prdx5 Prdx6 Prxl2a Sod1 Sod2 Txn2 Txnrd1 Txnrd2
|
||||
Metabolism > Detoxification > Amidoxime reducing complex MitoCarta3.0 Cyb5b Cyb5r3 Mtarc1 Mtarc2
|
||||
Metabolism > Detoxification > Selenoproteins MitoCarta3.0 Gpx1 Gpx4 Selenoo Txnrd1 Txnrd2
|
||||
Metabolism > Electron carriers MitoCarta3.0 Chdh Cyb5b Cyc1 Cycs Cyct Dhodh Etfa Etfb Etfbkmt Etfdh Etfrf1 Gpd2 Prodh Prodh2 Sqor mt-Cytb
|
||||
Metabolism > Electron carriers > Cytochromes MitoCarta3.0 Cyb5b Cyc1 Cycs Cyct mt-Cytb
|
||||
Metabolism > Electron carriers > Q-linked reactions, other MitoCarta3.0 Chdh Dhodh Etfa Etfb Etfbkmt Etfdh Etfrf1 Gpd2 Prodh Prodh2 Sqor
|
||||
Metabolism > Sulfur metabolism MitoCarta3.0 Ethe1 Got2 Mpst Msra Msrb2 Slc25a14 Slc25a30 Sqor Suox Tst Tstd1
|
||||
Small molecule transport MitoCarta3.0 Abca9 Abcb10 Abcb6 Abcb7 Abcb8 Abcd1 Abcd2 Abcd3 Ccdc51 Gm4984 Letmd1 Mcu Mcub Micu1 Micu2 Micu3 Mpc1 Mpc2 Mpv17 Mpv17l Mrs2 Mtch1 Mtch2 Romo1 Sfxn1 Sfxn2 Sfxn3 Sfxn4 Sfxn5 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a16 Slc25a18 Slc25a19 Slc25a2 Slc25a20 Slc25a21 Slc25a22 Slc25a23 Slc25a24 Slc25a25 Slc25a26 Slc25a27 Slc25a28 Slc25a29 Slc25a3 Slc25a30 Slc25a31 Slc25a32 Slc25a33 Slc25a34 Slc25a35 Slc25a36 Slc25a37 Slc25a38 Slc25a39 Slc25a4 Slc25a40 Slc25a41 Slc25a42 Slc25a43 Slc25a44 Slc25a45 Slc25a46 Slc25a47 Slc25a48 Slc25a5 Slc25a51 Slc25a53 Slc25a54 Slc30a9 Slc8b1 Smdt1 Stard7 Ucp1 Ucp2 Ucp3 Vdac1 Vdac2 Vdac3
|
||||
Small molecule transport > SLC25A family MitoCarta3.0 Mtch1 Mtch2 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a16 Slc25a18 Slc25a19 Slc25a2 Slc25a20 Slc25a21 Slc25a22 Slc25a23 Slc25a24 Slc25a25 Slc25a26 Slc25a27 Slc25a28 Slc25a29 Slc25a3 Slc25a30 Slc25a31 Slc25a32 Slc25a33 Slc25a34 Slc25a35 Slc25a36 Slc25a37 Slc25a38 Slc25a39 Slc25a4 Slc25a40 Slc25a41 Slc25a42 Slc25a43 Slc25a44 Slc25a45 Slc25a46 Slc25a47 Slc25a48 Slc25a5 Slc25a51 Slc25a53 Slc25a54 Ucp1 Ucp2 Ucp3
|
||||
Small molecule transport > ABC transporters MitoCarta3.0 Abca9 Abcb10 Abcb6 Abcb7 Abcb8 Abcd1 Abcd2 Abcd3
|
||||
Small molecule transport > Sideroflexins MitoCarta3.0 Sfxn1 Sfxn2 Sfxn3 Sfxn4 Sfxn5
|
||||
Signaling MitoCarta3.0 Acod1 Adcy10 Akap1 Akap10 Bloc1s1 C1qbp Cstad Dele1 Efhd1 Fundc2 Ifi27 Letm1 Lypla1 Macrod1 Mavs Mcrip2 Mcu Mcub Micu1 Micu2 Micu3 Mrs2 Mul1 Nlrx1 Ociad2 Pde2a Pink1 Ppif Pptc7 Prkaca Rhot1 Rhot2 Sirt3 Slc25a12 Slc25a13 Slc25a23 Slc25a24 Slc25a25 Slc25a3 Slc25a31 Slc25a4 Slc25a5 Slc8b1 Smdt1 Sphkap Vdac1 Vdac3
|
||||
Signaling > Calcium homeostasis MitoCarta3.0 Efhd1 Letm1 Mcu Mcub Micu1 Micu2 Micu3 Ppif Rhot1 Rhot2 Slc25a12 Slc25a13 Slc25a23 Slc25a24 Slc25a25 Slc25a3 Slc25a31 Slc25a4 Slc25a5 Slc8b1 Smdt1 Vdac1 Vdac3
|
||||
Small molecule transport > Calcium uniporter MitoCarta3.0 Mcu Mcub Micu1 Micu2 Micu3 Smdt1
|
||||
Signaling > Calcium homeostasis > Calcium cycle MitoCarta3.0 Letm1 Mcu Mcub Micu1 Micu2 Micu3 Slc25a3 Slc8b1 Smdt1
|
||||
Signaling > Calcium homeostasis > Mitochondrial permeability transition pore MitoCarta3.0 Ppif Slc25a31 Slc25a4 Slc25a5 Vdac1 Vdac3
|
||||
Signaling > Calcium homeostasis > EF hand proteins MitoCarta3.0 Efhd1 Micu1 Micu2 Micu3 Rhot1 Rhot2 Slc25a12 Slc25a13 Slc25a23 Slc25a24 Slc25a25
|
||||
Signaling > Immune response MitoCarta3.0 Acod1 C1qbp Cstad Ifi27 Mavs Nlrx1
|
||||
Signaling > cAMP-PKA signaling MitoCarta3.0 Adcy10 Akap1 Akap10 Pde2a Prkaca Sphkap
|
||||
Mitochondrial dynamics and surveillance MitoCarta3.0 Ahcyl1 Aifm1 Aifm2 Aifm3 Apoo Apool Arl2 Armc10 Armcx1 Armcx3 Atad3a Atp5k Atp5l Atp5md Bad Bak1 Bax Bbc3 Bcl2 Bcl2a1d Bcl2l1 Bcl2l10 Bcl2l11 Bcl2l13 Bcl2l2 Bid Bik Bnip3 Bnip3l Bok Casp3 Casp8 Casp9 Chchd2 Chchd3 Chchd6 Cycs Diablo Dnajc11 Dnm1l Endog Fis1 Fkbp8 Fundc1 Fundc2 Ghitm Htra2 Ifi27 Immt Marchf5 Mcl1 Mff Mfn1 Mfn2 Mgarp Micos10 Micos13 Mief1 Mief2 Miga1 Miga2 Mtch2 Mtfp1 Mtfr1 Mtfr2 Mtx1 Mtx2 Mtx3 Mul1 Myo19 Nbr1 Nipsnap1 Nipsnap2 Oma1 Opa1 Park7 Parl Pgam5 Pigbos1 Pink1 Pld6 Pmaip1 Prkn Rab24 Rhot1 Rhot2 Rmdn3 Samm50 Septin4 Slc25a46 Snap29 Sphk2 Spire1 Stx17 Styxl1 Synj2bp Tmem11 Tomm20 Tomm7 Usp30 Vdac1 Vps13d
|
||||
Mitochondrial dynamics and surveillance > Fusion MitoCarta3.0 Arl2 Mfn1 Mfn2 Miga1 Miga2 Mtch2 Oma1 Opa1 Pld6
|
||||
Mitochondrial dynamics and surveillance > Fission MitoCarta3.0 Armc10 Dnm1l Fis1 Mff Mief1 Mief2 Mtfp1 Mtfr1 Mtfr2 Mul1 Oma1 Rab24 Slc25a46 Spire1 Stx17
|
||||
Mitochondrial dynamics and surveillance > Organelle contact sites MitoCarta3.0 Ahcyl1 Atad3a Fkbp8 Fundc2 Mfn1 Mfn2 Miga2 Pigbos1 Rmdn3 Spire1 Stx17 Synj2bp Vdac1
|
||||
Mitochondrial dynamics and surveillance > Intramitochondrial membrane interactions MitoCarta3.0 Atad3a Chchd3 Dnajc11 Mtx1 Mtx2 Mtx3 Samm50 Slc25a46
|
||||
Mitochondrial dynamics and surveillance > Trafficking MitoCarta3.0 Armc10 Armcx1 Armcx3 Mgarp Myo19 Rhot1 Rhot2
|
||||
Mitochondrial dynamics and surveillance > Mitophagy MitoCarta3.0 Bcl2l13 Fkbp8 Fundc1 Marchf5 Nipsnap1 Nipsnap2 Park7 Parl Pgam5 Pink1 Prkn Tomm7 Usp30 Vps13d
|
||||
Mitochondrial dynamics and surveillance > Autophagy MitoCarta3.0 Bcl2l13 Fkbp8 Fundc1 Marchf5 Nbr1 Nipsnap1 Nipsnap2 Park7 Parl Pgam5 Pink1 Prkn Rab24 Snap29 Stx17 Tomm7 Usp30 Vps13d
|
||||
Mitochondrial dynamics and surveillance > Apoptosis MitoCarta3.0 Aifm1 Aifm2 Aifm3 Bad Bak1 Bax Bbc3 Bcl2 Bcl2a1d Bcl2l1 Bcl2l10 Bcl2l11 Bcl2l13 Bcl2l2 Bid Bik Bnip3 Bnip3l Bok Casp3 Casp8 Casp9 Chchd2 Cycs Diablo Endog Ghitm Htra2 Ifi27 Mcl1 Pmaip1 Septin4 Sphk2 Styxl1
|
||||
Mitochondrial dynamics and surveillance > Cristae formation MitoCarta3.0 Apoo Apool Atp5k Atp5l Atp5md Chchd3 Chchd6 Immt Micos10 Micos13 Opa1
|
||||
Mitochondrial dynamics and surveillance > Cristae formation > MICOS complex MitoCarta3.0 Apoo Apool Chchd3 Chchd6 Immt Micos10 Micos13
|
||||
@@ -0,0 +1,7 @@
|
||||
Metabolism MitoCarta3.0 Aadat Aass Abat Abcb10 Abcb6 Abcb7 Abhd10 Abhd11 Acaa1a Acaa1b Acaa2 Acaca Acacb Acad10 Acad11 Acad12 Acad8 Acadl Acadm Acads Acadsb Acadvl Acat1 Acly Aco2 Acod1 Acot10 Acot11 Acot13 Acot2 Acot7 Acot9 Acp6 Acsf2 Acsf3 Acsl1 Acsl6 Acsm1 Acsm2 Acsm3 Acsm4 Acsm5 Acss1 Acss3 Adhfe1 Agk Agmat Agpat4 Agpat5 Agxt Agxt2 Aifm2 Aifm3 Ak2 Ak3 Ak4 Akr1b10 Akr1b7 Akr7a5 Alas1 Alas2 Aldh18a1 Aldh1b1 Aldh1l1 Aldh1l2 Aldh2 Aldh3a2 Aldh4a1 Aldh5a1 Aldh6a1 Aldh7a1 Aldh9a1 Amacr Amt Antkmt Arg2 Auh Bcat2 Bckdha Bckdhb Bckdk Bco2 Bdh1 Bola1 Bola3 Bphl Car5a Car5b Cat Cbr2 Cbr3 Cbr4 Chchd7 Chdh Chpt1 Cisd1 Cisd3 Ckmt1 Ckmt2 Clybl Cmpk2 Coasy Comt Coq10a Coq10b Coq2 Coq3 Coq4 Coq5 Coq6 Coq7 Coq8a Coq8b Coq9 Cox10 Cox11 Cox15 Cox17 Cox19 Cpox Cps1 Cpt1a Cpt1b Cpt1c Cpt2 Crat Crls1 Crot Cs Cyb5b Cyb5r3 Cyc1 Cycs Cyct Cyp11a1 Cyp11b1 Cyp11b2 Cyp24a1 Cyp27a1 Cyp27b1 D2hgdh Dbi Dbt Dcxr Decr1 Dglucy Dguok Dhodh Dhrs1 Dhrs2 Dhrs4 Dhtkd1 Dlat Dld Dlst Dmgdh Dna2 Dut Ech1 Echdc1 Echs1 Eci1 Eci2 Ehhadh Ephx2 Etfa Etfb Etfbkmt Etfdh Etfrf1 Ethe1 Fabp1 Fahd1 Fam210b Fasn Fdps Fdx1 Fdx2 Fdxr Fech Fh1 Fhit Flad1 Fpgs Fth1 Ftmt Fxn Gatm Gcat Gcdh Gcsh Gldc Glrx2 Glrx5 Gls Gls2 Glud1 Glyat Glyctk Gm4952 Gm4984 Got2 Gpam Gpat2 Gpd2 Gpt2 Gpx1 Gpx4 Grhpr Grpel1 Grpel2 Gsr Gstk1 Gstz1 Gtpbp3 Guk1 H2-Ke6 Hadh Hadha Hadhb Hagh Hao2 Hccs Hibadh Hibch Hint1 Hint2 Hmgcl Hmgcs2 Hoga1 Hscb Hsd17b10 Hsd17b4 Hspa9 Htd2 Iba57 Idh2 Idh3a Idh3b Idh3g Idi1 Isca1 Isca2 Iscu Ivd Kmo Kyat3 L2hgdh Lactb Ldhal6b Ldhb Ldhd Lias Lipt1 Lipt2 Lypla1 Lyplal1 Lyrm4 Maoa Maob Mcat Mccc1 Mccc2 Mcee Mdh2 Me2 Me3 Mecr Mgst1 Mgst3 Mlycd Mmaa Mmab Mmadhc Mmut Mocs1 Mpc1 Mpc2 Mpst Mrps36 Msra Msrb2 Msrb3 Mtarc1 Mtarc2 Mtfmt Mthfd1l Mthfd2 Mthfd2l Mthfs Mthfsl Mto1 Nadk2 Nags Nat8l Naxd Naxe Ndufab1 Ndufs1 Ndufs2 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Neu4 Nfs1 Nfu1 Nit1 Nit2 Nme3 Nme4 Nme6 Nmnat3 Nnt Noct Nt5dc2 Nt5m Nthl1 Nubpl Nudt13 Nudt19 Nudt2 Nudt5 Nudt8 Nudt9 Oat Ogdh Ogdhl Osbpl1a Otc Oxct1 Oxct2a Oxr1 Oxsm Paics Pank2 Pcbd2 Pcca Pccb Pck2 Pcx Pdha1 Pdha2 Pdhb Pdhx Pdk1 Pdk2 Pdk3 Pdk4 Pdp1 Pdp2 Pdpr Pdss1 Pdss2 Pgs1 Phyh Pisd Pld6 Plpbp Plscr3 Pnpla8 Pnpo Ppa2 Ppm1k Ppox Prdx2 Prdx3 Prdx4 Prdx5 Prdx6 Prelid1 Prelid3a Prelid3b Prodh Prodh2 Prxl2a Ptges2 Ptpmt1 Pycr1 Pycr2 Qdpr Rdh13 Rdh14 Rfk Rpia Rsad1 Sardh Sco1 Sco2 Scp2 Sdha Sdhb Sdhc Sdhd Sdsl Selenoo Serac1 Sfxn1 Sfxn3 Sfxn5 Shmt2 Sirt3 Sirt4 Sirt5 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a19 Slc25a2 Slc25a20 Slc25a21 Slc25a23 Slc25a24 Slc25a25 Slc25a28 Slc25a29 Slc25a3 Slc25a30 Slc25a31 Slc25a32 Slc25a33 Slc25a36 Slc25a37 Slc25a38 Slc25a4 Slc25a41 Slc25a42 Slc25a44 Slc25a5 Slc25a51 Sod1 Sod2 Sphk2 Spr Sptlc2 Sqor Star Stard7 Sucla2 Suclg1 Suclg2 Sugct Suox Tamm41 Taz Them4 Them5 Tk2 Tmlhe Triap1 Tspo Tst Tstd1 Txn2 Txnrd1 Txnrd2 Uqcrfs1 Zadh2 mt-Co1 mt-Cytb
|
||||
Mitochondrial central dogma MitoCarta3.0 2810006K23Rik Aars2 Alkbh1 Angel2 Apex1 Atad3a Aurkaip1 Cars2 Cdk5rap1 Chchd1 Coa3 Cox14 Dap3 Dars2 Ddx28 Dhx30 Dna2 Dus2 Ears2 Elac2 Endog Eral1 Exd2 Exog Fars2 Fastk Fastkd1 Fastkd2 Fastkd3 Fastkd5 Gadd45gip1 Gars Gatb Gatc Gfm1 Gfm2 Grsf1 Gtpbp10 Gtpbp3 Guf1 Hars2 Hemk1 Hsd17b10 Iars2 Kars Lactb2 Lars2 Lig3 Lrpprc Malsu1 Mars2 Metap1d Mettl15 Mettl17 Mettl4 Mettl5 Mettl8 Mgme1 Mief1 Mpv17l2 Mrm1 Mrm2 Mrm3 Mrpl1 Mrpl10 Mrpl11 Mrpl12 Mrpl13 Mrpl14 Mrpl15 Mrpl16 Mrpl17 Mrpl18 Mrpl19 Mrpl2 Mrpl20 Mrpl21 Mrpl22 Mrpl23 Mrpl24 Mrpl27 Mrpl28 Mrpl3 Mrpl30 Mrpl32 Mrpl33 Mrpl34 Mrpl35 Mrpl36 Mrpl37 Mrpl38 Mrpl39 Mrpl4 Mrpl40 Mrpl41 Mrpl42 Mrpl43 Mrpl44 Mrpl45 Mrpl46 Mrpl47 Mrpl48 Mrpl49 Mrpl50 Mrpl51 Mrpl52 Mrpl53 Mrpl54 Mrpl55 Mrpl57 Mrpl58 Mrpl9 Mrps10 Mrps11 Mrps12 Mrps14 Mrps15 Mrps16 Mrps17 Mrps18a Mrps18b Mrps18c Mrps2 Mrps21 Mrps22 Mrps23 Mrps24 Mrps25 Mrps26 Mrps27 Mrps28 Mrps30 Mrps31 Mrps33 Mrps34 Mrps35 Mrps36 Mrps5 Mrps6 Mrps7 Mrps9 Mrrf Mterf1a Mterf1b Mterf2 Mterf3 Mterf4 Mtfmt Mtg1 Mtg2 Mtif2 Mtif3 Mto1 Mtpap Mtres1 Mtrf1 Mtrf1l Mutyh Myg1 Nars2 Ngrn Noa1 Nsun2 Nsun3 Nsun4 Ogg1 Osgepl1 Oxa1l Pars2 Pde12 Pdf Pif1 Pnpt1 Polb Poldip2 Polg Polg2 Polq Polrmt Ppa2 Primpol Prorp Ptcd1 Ptcd2 Ptcd3 Pus1 Pusl1 Qrsl1 Qtrt1 Rars2 Rbfa Rcc1l Recql4 Rexo2 Rmnd1 Rnaseh1 Rpusd3 Rpusd4 Sars2 Slirp Ssbp1 Supv3l1 Taco1 Tars2 Tbrg4 Tefm Tfam Tfb1m Tfb2m Thg1l Timm21 Top1mt Top3a Trit1 Trmt1 Trmt10c Trmt2b Trmt5 Trmu Trnt1 Trub2 Tsfm Tufm Twnk Ung Vars2 Wars2 Yars2 Ybey Yrdc
|
||||
Mitochondrial dynamics and surveillance MitoCarta3.0 Ahcyl1 Aifm1 Aifm2 Aifm3 Apoo Apool Arl2 Armc10 Armcx1 Armcx3 Atad3a Atp5k Atp5l Atp5md Bad Bak1 Bax Bbc3 Bcl2 Bcl2a1d Bcl2l1 Bcl2l10 Bcl2l11 Bcl2l13 Bcl2l2 Bid Bik Bnip3 Bnip3l Bok Casp3 Casp8 Casp9 Chchd2 Chchd3 Chchd6 Cycs Diablo Dnajc11 Dnm1l Endog Fis1 Fkbp8 Fundc1 Fundc2 Ghitm Htra2 Ifi27 Immt Marchf5 Mcl1 Mff Mfn1 Mfn2 Mgarp Micos10 Micos13 Mief1 Mief2 Miga1 Miga2 Mtch2 Mtfp1 Mtfr1 Mtfr2 Mtx1 Mtx2 Mtx3 Mul1 Myo19 Nbr1 Nipsnap1 Nipsnap2 Oma1 Opa1 Park7 Parl Pgam5 Pigbos1 Pink1 Pld6 Pmaip1 Prkn Rab24 Rhot1 Rhot2 Rmdn3 Samm50 Septin4 Slc25a46 Snap29 Sphk2 Spire1 Stx17 Styxl1 Synj2bp Tmem11 Tomm20 Tomm7 Usp30 Vdac1 Vps13d
|
||||
OXPHOS MitoCarta3.0 Acad9 Aifm1 Atp5a1 Atp5b Atp5c1 Atp5d Atp5e Atp5g1 Atp5g2 Atp5g3 Atp5h Atp5j Atp5j2 Atp5k Atp5l Atp5md Atp5mpl Atp5o Atp5pb Atpaf1 Atpaf2 Atpif1 Atpsckmt Bcs1l Cep89 Cmc1 Cmc2 Coa3 Coa4 Coa5 Coa6 Coa7 Coa8 Cox10 Cox11 Cox14 Cox15 Cox16 Cox17 Cox18 Cox19 Cox20 Cox4i1 Cox4i2 Cox5a Cox5b Cox6a1 Cox6a2 Cox6b1 Cox6b2 Cox6c Cox7a1 Cox7a2 Cox7a2l Cox7b Cox7c Cox8a Cox8b Cox8c Cyc1 Cycs Cyct Dmac1 Dmac2 Dmac2l Ecsit Fmc1 Foxred1 Hccs Higd1a Higd2a Lyrm2 Lyrm7 Ndufa1 Ndufa10 Ndufa11 Ndufa12 Ndufa13 Ndufa2 Ndufa3 Ndufa4 Ndufa5 Ndufa6 Ndufa7 Ndufa8 Ndufa9 Ndufab1 Ndufaf1 Ndufaf2 Ndufaf3 Ndufaf4 Ndufaf5 Ndufaf6 Ndufaf7 Ndufaf8 Ndufb10 Ndufb11 Ndufb2 Ndufb3 Ndufb4 Ndufb5 Ndufb6 Ndufb7 Ndufb8 Ndufb9 Ndufc1 Ndufc2 Ndufs1 Ndufs2 Ndufs3 Ndufs4 Ndufs5 Ndufs6 Ndufs7 Ndufs8 Ndufv1 Ndufv2 Ndufv3 Nubpl Pet100 Pet117 Pnkd Rab5if Sco1 Sco2 Sdha Sdhaf1 Sdhaf2 Sdhaf3 Sdhaf4 Sdhb Sdhc Sdhd Smim20 Surf1 Taco1 Timm21 Timmdc1 Tmem126a Tmem126b Tmem177 Tmem186 Tmem70 Ttc19 Uqcc1 Uqcc2 Uqcc3 Uqcr10 Uqcr11 Uqcrb Uqcrc1 Uqcrc2 Uqcrfs1 Uqcrh Uqcrq mt-Atp6 mt-Atp8 mt-Co1 mt-Co2 mt-Co3 mt-Cytb mt-Nd1 mt-Nd2 mt-Nd3 mt-Nd4 mt-Nd4l mt-Nd5 mt-Nd6
|
||||
Protein import, sorting and homeostasis MitoCarta3.0 Afg1l Afg3l1 Afg3l2 Agk Aifm1 Atad1 Atp23 Casp3 Casp8 Casp9 Chchd4 Clpb Clpp Clpx Dnaja3 Dnajc11 Dnajc15 Dnajc19 Dnajc4 Dnlz Fkbp10 Gfer Grpel1 Grpel2 Hspd1 Hspe1 Htra2 Ide Immp1l Immp2l Lactb Lap3 Lonp1 Maip1 Metap1d Mipep Mtx1 Mtx2 Mul1 Nln Nrd1 Oma1 Oxa1l Pam16 Park7 Parl Pdf Phb Phb2 Pitrm1 Pmpca Pmpcb Prss35 Romo1 Samm50 Spg7 Stoml2 Timm10 Timm10b Timm13 Timm17a Timm17b Timm21 Timm22 Timm23 Timm29 Timm44 Timm50 Timm8a1 Timm8a2 Timm8b Timm9 Tomm20 Tomm20l Tomm22 Tomm34 Tomm40 Tomm40l Tomm5 Tomm6 Tomm7 Tomm70a Trap1 Uqcrc1 Uqcrc2 Usp30 Xpnpep3 Yme1l1
|
||||
Signaling MitoCarta3.0 Acod1 Adcy10 Akap1 Akap10 Bloc1s1 C1qbp Cstad Dele1 Efhd1 Fundc2 Ifi27 Letm1 Lypla1 Macrod1 Mavs Mcrip2 Mcu Mcub Micu1 Micu2 Micu3 Mrs2 Mul1 Nlrx1 Ociad2 Pde2a Pink1 Ppif Pptc7 Prkaca Rhot1 Rhot2 Sirt3 Slc25a12 Slc25a13 Slc25a23 Slc25a24 Slc25a25 Slc25a3 Slc25a31 Slc25a4 Slc25a5 Slc8b1 Smdt1 Sphkap Vdac1 Vdac3
|
||||
Small molecule transport MitoCarta3.0 Abca9 Abcb10 Abcb6 Abcb7 Abcb8 Abcd1 Abcd2 Abcd3 Ccdc51 Gm4984 Letmd1 Mcu Mcub Micu1 Micu2 Micu3 Mpc1 Mpc2 Mpv17 Mpv17l Mrs2 Mtch1 Mtch2 Romo1 Sfxn1 Sfxn2 Sfxn3 Sfxn4 Sfxn5 Slc25a1 Slc25a10 Slc25a11 Slc25a12 Slc25a13 Slc25a14 Slc25a15 Slc25a16 Slc25a18 Slc25a19 Slc25a2 Slc25a20 Slc25a21 Slc25a22 Slc25a23 Slc25a24 Slc25a25 Slc25a26 Slc25a27 Slc25a28 Slc25a29 Slc25a3 Slc25a30 Slc25a31 Slc25a32 Slc25a33 Slc25a34 Slc25a35 Slc25a36 Slc25a37 Slc25a38 Slc25a39 Slc25a4 Slc25a40 Slc25a41 Slc25a42 Slc25a43 Slc25a44 Slc25a45 Slc25a46 Slc25a47 Slc25a48 Slc25a5 Slc25a51 Slc25a53 Slc25a54 Slc30a9 Slc8b1 Smdt1 Stard7 Ucp1 Ucp2 Ucp3 Vdac1 Vdac2 Vdac3
|
||||
File diff suppressed because it is too large
Load Diff
File diff suppressed because it is too large
Load Diff
@@ -0,0 +1,18 @@
|
||||
# MitoCarta3.0（小鼠）结构化提取
|
||||
|
||||
来源：`ref/Mouse.MitoCarta3.0.xls`（Broad Institute MitoCarta3.0，Rath et al. 2021, NAR）。
|
||||
由 `script/18_mitocarta_extract.py` 生成，勿手改。
|
||||
|
||||
| 文件 | 内容 |
|
||||
|---|---|
|
||||
| `Mouse_MitoCarta3.0_genes.csv` | 1140 个线粒体定位基因：Symbol、亚线粒体定位（Matrix/MIM/MOM/IMS）、所属 MitoPathways、证据 |
|
||||
| `MitoPathways.csv` | 149 条通路 + 层级（L1/L2/L3）+ 基因数 |
|
||||
| `MitoPathways_long.csv` | 基因 × 通路长表，1037 个基因 |
|
||||
| `MitoPathways.gmt` | 全层级 term 的 GMT，供 gseapy prerank |
|
||||
| `MitoPathways_L1.gmt` | 7 个一级大类 GMT，供模块打分 |
|
||||
|
||||
与本项目分析的直接衔接：
|
||||
- 模块打分可用 L1/L2 级基因集（如 OXPHOS > Complex I）替代 P0/P1 手工整理的 ETC/CI 列表做敏感性核对；
|
||||
- GSEA prerank 可用 `MitoPathways.gmt` 补充 Hallmark 覆盖不到的线粒体特异通路
|
||||
（mtDNA maintenance、mito-ribosome、Fe-S cluster、mitophagy 等）；
|
||||
- 基因 Symbol 为小鼠原始大小写，与本项目 var_names 直接兼容（已核实分隔符为 ", "）。
|
||||
@@ -51,9 +51,12 @@ ax.set_yticks(range(len(genes)), genes, fontsize=7)
|
||||
for i in range(len(genes)):
|
||||
for j in range(len(groups_pb)):
|
||||
v = mat[groups_pb].values[i, j]
|
||||
if np.isnan(v):
|
||||
ax.text(j, i, "n.d.", ha="center", va="center", fontsize=5, color="grey")
|
||||
continue
|
||||
ax.text(j, i, f"{v:+.1f}", ha="center", va="center", fontsize=6,
|
||||
color="white" if abs(v) > 0.7 * vmax else "black")
|
||||
ax.set_title("IFN–JAK–STAT 逐基因 LFC（突变−WT，pseudobulk）")
|
||||
ax.set_title("IFN-JAK-STAT gene-level LFC (V291D - WT, pseudobulk)")
|
||||
fig.colorbar(im, ax=ax, label="mean LFC (S1,S2)")
|
||||
fig.tight_layout()
|
||||
fig.savefig(OUT / "ifn_gene_heatmap.png", bbox_inches="tight")
|
||||
@@ -68,7 +71,7 @@ ax.set_yticks(range(len(mg_genes)), mg_genes, fontsize=7)
|
||||
ax.set_xticks([])
|
||||
for i, g in enumerate(mg_genes):
|
||||
ax.text(0, i, f"{det_delta[g]:+.2f}", ha="center", va="center", fontsize=6)
|
||||
ax.set_title("Microglia Δ检出率\n(WT 8 核，仅方向)")
|
||||
ax.set_title("Microglia detection-rate diff\n(WT n=8 nuclei, direction only)")
|
||||
fig.colorbar(im, ax=ax, label="Δdet")
|
||||
fig.tight_layout()
|
||||
fig.savefig(OUT / "ifn_gene_heatmap_microglia.png", bbox_inches="tight")
|
||||
@@ -140,7 +143,7 @@ ax.bar(x + w/2, np.log10(cw["pseudo_ratio"]), width=w, color="teal", label="pseu
|
||||
ax.axhline(0, color="k", lw=0.5)
|
||||
ax.set_xticks(x, cw["group"])
|
||||
ax.set_ylabel("log10(UP/DOWN)")
|
||||
ax.set_title("细胞级 vs pseudobulk DE 方向偏斜（灰=细胞级被深度污染，类作者 artifact）")
|
||||
ax.set_title("Cell-level vs pseudobulk DE direction bias (grey = depth-biased, author-like artifact)")
|
||||
ax.legend(fontsize=7, frameon=False)
|
||||
fig.tight_layout()
|
||||
fig.savefig(OUT / "celllevel_vs_pseudobulk.png", bbox_inches="tight")
|
||||
|
||||
@@ -0,0 +1,91 @@
|
||||
#!/usr/bin/env python
|
||||
# -*- coding: utf-8 -*-
|
||||
"""
|
||||
18_mitocarta_extract.py — 将 ref/Mouse.MitoCarta3.0.xls 结构化提取为可复用资产
|
||||
|
||||
产出（按用户指示存回 ref/mitocarta3.0/，属"参考资产结构化"而非改动原始文件）：
|
||||
1. Mouse_MitoCarta3.0_genes.csv 1140 个小鼠线粒体基因主表（Symbol/亚线粒体定位/通路归属/证据）
|
||||
2. MitoPathways.csv 149 条 MitoPathway，层级拆分为 L1/L2/L3 + 基因数
|
||||
3. MitoPathways_long.csv 基因 × 通路 长表（一个基因可属多条通路）
|
||||
4. MitoPathways.gmt GMT 格式（全层级路径为 term 名），供 gseapy prerank
|
||||
5. MitoPathways_L1.gmt 仅一级通路（8 大类），供粗粒度模块打分
|
||||
6. README.md 来源与字段说明
|
||||
"""
|
||||
from pathlib import Path
|
||||
|
||||
import pandas as pd
|
||||
|
||||
SRC = Path("ref/Mouse.MitoCarta3.0.xls")
|
||||
OUT = Path("ref/mitocarta3.0")
|
||||
OUT.mkdir(parents=True, exist_ok=True)
|
||||
|
||||
xl = pd.ExcelFile(SRC)
|
||||
|
||||
# ---- 1. 主基因表 ----
|
||||
genes = xl.parse("A Mouse MitoCarta3.0")[
|
||||
["MouseGeneID", "Symbol", "HumanOrthologGeneID", "Description",
|
||||
"MitoCarta3.0_Evidence", "MitoCarta3.0_SubMitoLocalization",
|
||||
"MitoCarta3.0_MitoPathways"]
|
||||
].rename(columns={
|
||||
"MitoCarta3.0_Evidence": "Evidence",
|
||||
"MitoCarta3.0_SubMitoLocalization": "SubMitoLocalization",
|
||||
"MitoCarta3.0_MitoPathways": "MitoPathways",
|
||||
})
|
||||
genes = genes[genes["Symbol"].notna()].reset_index(drop=True)
|
||||
genes.to_csv(OUT / "Mouse_MitoCarta3.0_genes.csv", index=False)
|
||||
print(f"genes: {len(genes)}")
|
||||
|
||||
# ---- 2. 通路表 + 层级拆分 ----
|
||||
pw = xl.parse("C MitoPathways")
|
||||
pw["n_genes"] = pw["Genes"].str.split(", ").str.len()
|
||||
hier = pw["MitoPathway Hierarchy"].str.split(" > ", expand=True)
|
||||
hier.columns = [f"L{i+1}" for i in range(hier.shape[1])]
|
||||
pw = pd.concat([pw, hier], axis=1)
|
||||
pw.to_csv(OUT / "MitoPathways.csv", index=False)
|
||||
print(f"pathways: {len(pw)}; L1 大类:")
|
||||
print(pw.groupby("L1")["n_genes"].agg(["count", "sum"]).to_string())
|
||||
|
||||
# ---- 3. 长表（基因 × 通路） ----
|
||||
rows = []
|
||||
for _, r in pw.iterrows():
|
||||
for g in str(r["Genes"]).split(", "):
|
||||
rows.append({"Symbol": g.strip(), "MitoPathway": r["MitoPathway"],
|
||||
"Hierarchy": r["MitoPathway Hierarchy"], "L1": r["L1"]})
|
||||
long = pd.DataFrame(rows)
|
||||
long.to_csv(OUT / "MitoPathways_long.csv", index=False)
|
||||
print(f"long rows: {len(long)}; unique genes in pathways: {long['Symbol'].nunique()}")
|
||||
|
||||
# ---- 4/5. GMT ----
|
||||
def write_gmt(df, term_col, path):
|
||||
with open(path, "w", encoding="utf-8") as f:
|
||||
for _, r in df.iterrows():
|
||||
gl = ", ".join(sorted(set(str(r["Genes"]).split(", "))))
|
||||
f.write(f"{r[term_col]}\tMitoCarta3.0\t{gl.replace(', ', chr(9))}\n")
|
||||
|
||||
write_gmt(pw, "MitoPathway Hierarchy", OUT / "MitoPathways.gmt")
|
||||
l1 = long.groupby("L1")["Symbol"].agg(lambda s: sorted(set(s))).reset_index()
|
||||
with open(OUT / "MitoPathways_L1.gmt", "w", encoding="utf-8") as f:
|
||||
for _, r in l1.iterrows():
|
||||
f.write(f"{r['L1']}\tMitoCarta3.0\t" + "\t".join(r["Symbol"]) + "\n")
|
||||
|
||||
# ---- 6. README ----
|
||||
(OUT / "README.md").write_text(f"""# MitoCarta3.0（小鼠）结构化提取
|
||||
|
||||
来源：`ref/Mouse.MitoCarta3.0.xls`（Broad Institute MitoCarta3.0，Rath et al. 2021, NAR）。
|
||||
由 `script/18_mitocarta_extract.py` 生成，勿手改。
|
||||
|
||||
| 文件 | 内容 |
|
||||
|---|---|
|
||||
| `Mouse_MitoCarta3.0_genes.csv` | {len(genes)} 个线粒体定位基因：Symbol、亚线粒体定位（Matrix/MIM/MOM/IMS）、所属 MitoPathways、证据 |
|
||||
| `MitoPathways.csv` | {len(pw)} 条通路 + 层级（L1/L2/L3）+ 基因数 |
|
||||
| `MitoPathways_long.csv` | 基因 × 通路长表，{long['Symbol'].nunique()} 个基因 |
|
||||
| `MitoPathways.gmt` | 全层级 term 的 GMT，供 gseapy prerank |
|
||||
| `MitoPathways_L1.gmt` | {len(l1)} 个一级大类 GMT，供模块打分 |
|
||||
|
||||
与本项目分析的直接衔接：
|
||||
- 模块打分可用 L1/L2 级基因集（如 OXPHOS > Complex I）替代 P0/P1 手工整理的 ETC/CI 列表做敏感性核对；
|
||||
- GSEA prerank 可用 `MitoPathways.gmt` 补充 Hallmark 覆盖不到的线粒体特异通路
|
||||
（mtDNA maintenance、mito-ribosome、Fe-S cluster、mitophagy 等）；
|
||||
- 基因 Symbol 为小鼠原始大小写，与本项目 var_names 直接兼容（已核实分隔符为 ", "）。
|
||||
""", encoding="utf-8")
|
||||
print("Done ->", OUT)
|
||||
Reference in New Issue
Block a user