RGC-ADOA/output/16_gsea/gsea_RGC1-like_Hallmark.csv

1	Name	Term	ES	NES	NOM p-val	FDR q-val	FWER p-val	Tag %	Gene %	Lead_genes
2	prerank	Oxidative Phosphorylation	0.619921119543991	2.3406622674210014	0.0	0.0	0.0	73/159	19.00%	Grpel1;Atp6v1f;Mrpl34;Uqcr11;Ndufs7;Ndufa1;Cox8a;Acadvl;Mdh2;Cox4i1;Phb2;Ndufs6;Cox6c;Ndufa2;Ndufa3;Timm10;Cox6b1;Casp7;Ndufc2;Bax;Htra2;Phyh;Timm13;Ndufb7;Ndufb5;Timm8b;Polr2f;Ndufb2;Ndufa7;Sdhd;Mrps22;Ndufv1;Ndufb8;Cox17;Cox5b;Ndufa4;Atp6ap1;Ndufa8;Cox5a;Ndufc1;Uqcrc1;Ndufb6;Ech1;Uqcr10;Gpx4;Por;Uqcrq;Vdac1;Ldha;Cox7c;Cox7a2;Uqcrb;Cycs;Surf1;Oxa1l;Atp1b1;Tomm22;Mfn2;Mgst3;Aldh6a1;Etfb;Cpt1a;Slc25a4;Cox7a2l;Ndufb3;Atp6v1d;Dld;Vdac2;Sdhb;Uqcrh;Hadhb;Hspa9;Cox7b
3	prerank	Reactive Oxygen Species Pathway	0.6434005446098667	1.9192917168244554	0.0	0.0033347448655515564	0.006	14/37	11.01%	Prdx4;Srxn1;Lamtor5;Prnp;Sbno2;Ercc2;Prdx6;Junb;Cdkn2d;Atox1;Cat;Glrx;Oxsr1;Gpx4
4	prerank	p53 Pathway	0.4542903018399436	1.6212700640313085	0.0	0.08448020326063943	0.201	40/102	22.11%	Ddit3;Ctsd;Hras;Ier3;Nupr1;Sat1;Bax;Rpl36;Jun;Rps12;Ctsf;Rack1;Wrap73;Hint1;Rrp8;Rpl18;Ndrg1;Tprkb;Cgrrf1;Pom121;Slc3a2;Fuca1;Tm7sf3;Polh;Cd81;Tob1;Pmm1;Zmat3;Hdac3;Hexim1;Pvt1;Plxnb2;Cdk5r1;Slc35d1;Acvr1b;Jag2;Cdh13;Csrnp2;Rchy1;Apaf1
5	prerank	Adipogenesis	0.4335678965104166	1.6164400505587286	0.0011695906432748538	0.0664170019055685	0.21	53/148	23.70%	Grpel1;Ccng2;Uqcr11;Cox8a;Chchd10;Apoe;Mdh2;Reep6;Ddt;Vegfb;Phyh;Slc27a1;Ndufb7;Slc5a6;Cat;Lpcat3;Cd151;Dnajb9;Phldb1;Uqcrc1;Ubc;Ech1;Ubqln1;Uqcr10;Gpx4;Por;Uqcrq;Aplp2;Aldoa;Tob1;Col4a1;Mgst3;Rreb1;Etfb;Ptcd3;Lifr;Gpat4;Dld;Rmdn3;Sdhb;Taldo1;Qdpr;Cox7b;Angpt1;Nabp1;Ifngr1;Pparg;Ndufa5;Ndufs3;Idh3g;Lipe;Tkt;Lama4
6	prerank	Epithelial Mesenchymal Transition	0.4426960476031183	1.5509308565475173	0.011873350923482849	0.10182087656150753	0.369	25/79	17.35%	Spp1;Fbln1;Cald1;Adam12;Sat1;Magee1;Slit3;Jun;Scg2;Gpc1;Bdnf;Fuca1;Lgals1;Fbn1;Plod1;Flna;Col11a1;Col4a1;Colgalt1;Pvr;Pfn2;Tgfbr3;Ppib;Plod3;Slc6a8
7	prerank	Myc Targets V1	0.40814294683439184	1.5367782955156422	0.0011737089201877935	0.09596654668642812	0.402	80/161	31.35%	Prdx4;Snrpd2;Phb2;Rpl34;Nme1;Rps10;Rps3;Ran;Rack1;Rpl18;Nolc1;Eif3d;Cox5a;Rsl1d1;Psma4;Pa2g4;Dut;Vdac1;Ldha;Cnbp;Rps2;Rplp0;Impdh2;Eef1b2;Pabpc4;Rpl6;Snrpg;Rps5;Rrp9;Psmd8;Eif4g2;Ppm1g;Odc1;Hspe1;Cct7;Rnps1;Tcp1;Ptges3;Set;Snrpd3;Srsf3;Clns1a;Cct5;Ppia;Uba2;Rpl14;Cct2;Psma7;Snrpa1;Ddx21;Hdgf;Xrcc6;Canx;Psmd3;Psma2;Usp1;Glo1;Mrpl23;Ifrd1;Ranbp1;Lsm7;U2af1;Eif3b;Psma6;Ndufab1;G3bp1;Phb;Hsp90ab1;Pcbp1;Psmb3;Sf3b3;Eif4h;Cct4;Cbx3;Hspd1;Rps6;Rpl22;Fbl;Psmc4;Pgk1
8	prerank	Hypoxia	0.4099888220656954	1.4860976501485275	0.014814814814814815	0.1324370103747618	0.555	28/110	14.94%	Ddit3;Ccng2;Csrp2;Ncan;Cited2;Ier3;Hspa5;Mif;Siah2;Jun;Slc37a4;Ndrg1;Ampd3;Chst2;Pgm2;Gpc1;Ankzf1;Glrx;Hexa;Has1;Gaa;Gapdh;Cdkn1b;Ldha;Aldoa;Anxa2;Aldoc;P4ha2
9	prerank	UV Response Up	0.42238379894098116	1.4790938295467728	0.012610340479192938	0.12282976921448233	0.58	26/85	17.38%	Grpel1;Atp6v1f;Rpn1;Pdap1;Bcl2l11;Casp3;Hspa13;Junb;Fkbp4;Creg1;Ret;Cebpg;Grina;Asns;Bsg;Ap2s1;Selenow;Kcnh2;Sigmar1;Aldoa;Psmc3;Nptxr;Tmbim6;Rxrb;Slc6a8;Slc25a4
10	prerank	Unfolded Protein Response	0.4174843795895568	1.4557584958398218	0.015444015444015444	0.13437786717481828	0.652	32/87	24.23%	Yif1a;Slc7a5;Rps14;Lsm4;Calr;Hspa5;Pdia6;Slc1a4;Eef2;Aldh18a1;Dnajb9;Cebpg;Nolc1;Asns;Xbp1;Herpud1;Tubb2a;Dcp2;Hyou1;Rrp9;Ssr1;Wipi1;Cxxc1;Hsp90b1;Hspa9;Dnaja4;Nabp1;Atf4;Imp3;Mthfd2;Nfyb;Tspyl2
11	prerank	IL-2/STAT5 Signaling	0.41711427714794586	1.447972040681071	0.023316062176165803	0.1300550497565107	0.672	27/89	23.53%	Spp1;Etv4;Penk;Wls;Prnp;Casp3;Ptrh2;Ndrg1;P2rx4;Gabarapl1;Xbp1;Nfkbiz;Twsg1;Gpx4;Cd81;Tnfrsf21;Gsto1;Lrig1;Ttc39b;Odc1;Plec;Dennd5a;Hk2;Ifngr1;Ahr;Aplp1;Scn9a
12	prerank	heme Metabolism	0.38127398011854036	1.3971966225563734	0.028151774785801713	0.17765095374665563	0.814	39/129	23.77%	Lrp10;Khnyn;Endod1;Rad23a;Bpgm;Htra2;Cat;Nfe2l1;Ppp2r5b;Adipor1;Pgls;Asns;Bsg;Blvra;Arl2bp;Slc25a37;Rcl1;Bach1;Gde1;Osbp2;Mgst3;P4ha2;Aldh6a1;Mospd1;Fn3k;Psmd9;Optn;Mpp1;Slc6a8;Fech;Nek7;Isca1;Alas2;Sidt2;Ranbp10;Acsl6;Gclm;Hdgf;Ctsb
13	prerank	mTORC1 Signaling	0.37340860855558616	1.3903486136073684	0.022592152199762187	0.17201725598136777	0.826	54/146	26.25%	Ddit3;Slc7a5;Rpn1;Pdap1;Calr;Nupr1;Hspa5;Nufip1;Lgmn;Slc1a4;Slc37a4;Asns;Xbp1;Glrx;Psma4;Gapdh;Ldha;Ppa1;Aldoa;Atp2a2;Psmb5;Rrp9;Ssr1;Cacybp;Ufm1;Abcf2;Hspe1;Atp6v1d;Pdk1;Hsp90b1;Ldlr;Gtf2h1;Hspa9;Qdpr;Idi1;Psme3;Hk2;Fkbp2;Ppia;Dhcr24;Sqstm1;Elovl5;Tpi1;Sqle;Sytl2;Hmgcs1;Mthfd2;Slc6a6;Psph;Canx;Ifrd1;Got1;Sc5d;Pgm1
14	prerank	Spermatogenesis	-0.35372317805680414	-1.3796487152906651	0.05785123966942149	0.4027504911591356	0.43	19/60	20.79%	Dmc1;Cnih2;Oaz3;Cftr;Camk4;Grm8;Pgs1;Slc12a2;Chfr;Clpb;Tle4;Rad17;Gmcl1;Braf;Pacrg;Arl4a;Adcyap1;Snap91;Ip6k1
15	prerank	Myogenesis	0.3844208121062666	1.3522962249111645	0.05157232704402516	0.21008892652974803	0.9	36/90	28.01%	Fxyd1;Ptp4a3;Adam12;Kifc3;Prnp;Cryab;Igfbp7;Kcnh1;Ckb;Pvalb;Clu;Actn2;Cacna1h;Atp6ap1;Cnn3;Gaa;Kcnh2;Fabp3;Fhl1;Slc6a8;Plxnb2;Akt2;Hdac5;Ppfia4;Psen2;Cdh13;Ptgis;Fdps;Pdlim7;Ifrd1;Adcy9;Flii;Myo1c;Reep1;Ocel1;Camk2b
16	prerank	Complement	0.38531825394882924	1.3459753948991577	0.06508135168961202	0.20516620791869578	0.911	14/88	7.62%	Gngt2;Ctsd;Prss36;Mmp15;Casp3;Hspa5;Sirt6;Lgmn;Casp7;Dgkg;Atox1;Clu;Actn2;Ctsl
17	prerank	Xenobiotic Metabolism	0.3831864788226124	1.3293073404406845	0.0678617157490397	0.2148316747829769	0.933	25/85	19.25%	Fbln1;Ptgds;Apoe;Lonp1;Ddt;Vtn;Dhrs1;Cat;Pgrmc1;Gabarapl1;Cbr1;Ech1;Por;Atp2a2;Pmm1;Abcd2;Slc46a3;Gsto1;Tmbim6;Pink1;Entpd5;Acox3;Ptges3;Slc35d1;Ssr3
18	prerank	DNA Repair	0.3679493401248192	1.3283374335454894	0.05375	0.2025162767308914	0.935	38/116	21.91%	Cetn2;Ercc2;Nme1;Rad51;Aprt;Polr3c;Polr2j;Guk1;Arl6ip1;Polr2e;Polr2f;Cant1;Pde6g;Polr2k;Pole4;Polr1d;Cox17;Pom121;Edf1;Polh;Gpx4;Dut;Surf1;Impdh2;Vps37b;Ercc8;Polr2c;Dad1;Eif1b;Nt5c;Gtf2h1;Dgcr8;Rbx1;Nelfcd;Nudt21;Adrm1;Taf10;Ssrp1
19	prerank	KRAS Signaling Up	0.377718191111655	1.304695877054277	0.10533159947984395	0.22885503979275384	0.961	15/78	16.19%	Spp1;Etv1;Gpnmb;Etv4;Nap1l2;Bpgm;Pcsk1n;Glrx;Fuca1;Dock2;Pcp4;Mmd;Gadd45g;Etv5;Ptcd2
20	prerank	Apoptosis	0.3798835725067369	1.3014662345553973	0.08122503328894808	0.22101947914461148	0.968	22/74	21.55%	Ddit3;Bcl2l11;Casp3;Ier3;Sat1;Casp7;Bax;Jun;Clu;Dpyd;Ppp2r5b;Gpx4;Cdkn1b;Nefh;Timp2;Tgfbr3;Vdac2;Mcl1;Psen2;Smad7;Sqstm1;Ifngr1
21	prerank	Glycolysis	0.3533024969072083	1.2934477159942654	0.07627118644067797	0.22313538451251994	0.972	40/124	22.18%	Chpf;Mdh2;Cited2;Copb2;Ier3;Hspa5;Slc25a13;Mif;Prps1;Fkbp4;Slc37a4;Pgls;Pgam1;Cacna1h;Chst2;Pgm2;Xylt2;Gpc1;Ankzf1;Glrx;Ldha;Ndufv3;Plod1;Gne;Aldoa;Hax1;Nol3;P4ha2;Chst12;Gmppa;Pkm;Dld;Taldo1;Ppfia4;B4galt4;Hk2;Ppia;Dpysl4;Tpi1;Polr3k
22	prerank	Bile Acid Metabolism	0.3696117390314927	1.20662816405311	0.17753120665742025	0.3670998306161339	0.998	18/57	23.27%	Ttr;Rbp1;Bmp6;Pex6;Phyh;Cat;Cyp46a1;Abca2;Abcd2;Prdx5;Optn;Slc29a1;Pex19;Idi1;Nudt12;Dhcr24;Gclm;Lipe
23	prerank	Apical Surface	-0.3985625019149619	-1.200579777651937	0.22969187675070027	0.6155861165684349	0.834	2/20	2.65%	Pkhd1;Crybg1
24	prerank	Hedgehog Signaling	-0.3537478281913628	-1.1829352572062866	0.22674418604651161	0.44968347522375024	0.862	4/27	8.33%	Cdk6;Shh;Unc5c;Tle1
25	prerank	Angiogenesis	0.45006017307214286	1.152849605704238	0.2857142857142857	0.4696167690027525	1.0	4/17	13.50%	Spp1;Vtn;Lrpap1;Tnfrsf21
26	prerank	Estrogen Response Early	0.3202577761175286	1.1457554653526965	0.24015247776365947	0.46539901449386945	1.0	18/103	13.09%	Celsr2;Slc7a5;Endod1;Podxl;Siah2;Hes1;Slc1a4;Fkbp4;Slc26a2;Cant1;Ret;Syt12;Slc1a1;Unc119;Xbp1;Slc22a5;Tob1;Syngr1
27	prerank	Inflammatory Response	0.343677014173989	1.1128593248951348	0.27034482758620687	0.5261164145854238	1.0	17/52	24.87%	Slc7a1;Chst2;Slc31a1;P2rx4;Atp2a2;Ly6e;Pvr;Tapbp;Ldlr;Acvr1b;Itga5;Selenos;Adrm1;Ahr;Ptger4;Cx3cl1;Gabbr1
28	prerank	Apical Junction	-0.2356305465622273	-1.0356495552232514	0.33163265306122447	0.75	0.982	36/117	25.49%	Col9a1;Egfr;Mmp9;Vav2;Itga10;Inppl1;Sorbs3;Map4k2;Epb41l2;Mpp5;Pik3r3;Jup;Cadm2;Lama3;Exoc4;Dlg1;Crat;Gnai1;Rsu1;Pik3cb;Actn1;Rasa1;Pbx2;Cdh11;Tjp1;Nf1;Baiap2;Pard6g;Akt3;Lima1;Wasl;Vcl;Ptk2;Adam9;Nf2;Itga9
29	prerank	Notch Signaling	0.399847827918841	1.0197119168626385	0.4358974358974359	0.7571260321829346	1.0	8/17	21.85%	Notch3;Hes1;Psenen;Dtx4;St3gal6;Rbx1;Psen2;Aph1a
30	prerank	Estrogen Response Late	0.28712203186271557	1.006757252677638	0.463254593175853	0.7633897946220622	1.0	15/81	12.51%	Celsr2;Slc7a5;Cox6c;Siah2;Ckb;Slc1a4;Fkbp4;Slc26a2;Fabp5;Ret;Mocs2;Xbp1;Slc22a5;Pcp4;Tob1
31	prerank	Androgen Response	0.2884323946031561	1.0015961386380297	0.45611702127659576	0.7471538624407563	1.0	24/74	25.55%	Dbi;Sat1;Slc26a2;Abcc4;Uap1;Ndrg1;Rab4a;Dnajb9;Pgm3;Pa2g4;Lifr;Srp19;Abhd2;Bmpr1b;Idi1;Adrm1;Dhcr24;Elovl5;Ube2j1;Lman1;Hmgcs1;Xrcc6;Sgk1;Iqgap2
32	prerank	Fatty Acid Metabolism	0.2808233490668568	0.9984402645691206	0.45591939546599497	0.7281271320017879	1.0	31/97	22.90%	Acadvl;Erp29;Mdh2;Reep6;Mif;Prdx6;Sdhd;Ncaph2;Gabarapl1;Blvra;Lgals1;Cbr1;Ech1;Hsdl2;Slc22a5;Ldha;Serinc1;Aldoa;Cpt1a;Odc1;Dld;Hadhb;Bmpr1b;Idi1;Hsp90aa1;Dhcr24;Eci2;Elovl5;Fasn;Idh3g;Hmgcs1
33	prerank	Pperoxisome	0.29520251049695345	0.97821913372473	0.5116598079561042	0.757661973322041	1.0	15/65	21.45%	Ttr;Pex6;Hras;Cat;Ech1;Cnbp;Nudt19;Pex2;Abcd2;Prdx5;Slc25a4;Idi1;Dhcr24;Eci2;Elovl5
34	prerank	Myc Targets V2	0.3284418751910447	0.9696695222900162	0.5	0.7518508107792389	1.0	19/33	33.29%	Tfb2m;Nolc1;Pa2g4;Rcl1;Rabepk;Rrp9;Hspe1;Hk2;Prmt3;Ndufaf4;Las1l;Mrto4;Pprc1;Phb;Cbx3;Hspd1;Npm1;Supv3l1;Mphosph10
35	prerank	TNF-alpha Signaling via NF-kB	0.26011523232554457	0.894600418023324	0.6771752837326608	0.9148687275037052	1.0	8/73	5.95%	Plpp3;Ier3;Sat1;Smad3;Hes1;Jun;Junb;Litaf
36	prerank	Coagulation	0.2927301625154501	0.8806583834528166	0.6666666666666666	0.9175568426300942	1.0	4/39	6.01%	Dct;Mmp15;Lgmn;Clu
37	prerank	PI3K/AKT/mTOR Signaling	0.24582824201503325	0.8558574210392627	0.6987620357634112	0.9455043801609148	1.0	19/79	24.71%	Ddit3;Hras;Calr;Gngt1;Csnk2b;Cdkn1b;Them4;Dusp3;Ralb;Arpc3;Ap2m1;Pdk1;Hsp90b1;Sqstm1;Pin1;Plcg1;Ripk1;Pla2g12a;Rps6ka1
38	prerank	Cholesterol Homeostasis	0.2739145845269427	0.8547575112449235	0.6930555555555555	0.9192443169788077	1.0	20/43	28.29%	Lgmn;Clu;Fabp5;Ech1;Abca2;Aldoc;Ldlr;Idi1;Pparg;Fasn;Sqle;Hmgcs1;Pmvk;Fdps;Pnrc1;Sc5d;Pcyt2;Acat2;Ctnnb1;Atf5
39	prerank	G2-M Checkpoint	0.23397119797899435	0.8494276587838939	0.7564259485924113	0.9039120200271512	1.0	39/117	30.73%	Slc7a5;Smad3;Slc7a1;Kif22;Jpt1;Nolc1;Pttg1;Chmp1a;Cdkn1b;Arid4a;E2f4;Lmnb1;Hspa8;Polq;Odc1;Lbr;Hira;Katna1;Meis2;Sqle;Ss18;Cdc25b;Ncl;Nsd2;Nasp;Pml;Tmpo;Smc2;G3bp1;Orc6;Atf5;Hmgn2;Prmt5;Upf1;Nup50;Uck2;Tle3;Brca2;Odf2
40	prerank	Pancreas Beta Cells	-0.27556487299059124	-0.8479661202906396	0.648876404494382	1.0	1.0	3/20	5.53%	Foxo1;Mafb;Slc2a2
41	prerank	E2F Targets	0.23035715984259164	0.8269813074733565	0.784409257003654	0.9224857082362905	1.0	17/108	11.77%	Prdx4;Prps1;Nme1;Spag5;Ncapd2;Ran;Kif22;Jpt1;Pole4;Lyar;Nolc1;Mms22l;Pttg1;Pa2g4;Cdkn1b;Dut;Phf5a
42	prerank	Interferon Gamma Response	0.23937713363156826	0.8015886390583518	0.803840877914952	0.9457706965911498	1.0	17/62	25.09%	Gpr18;Rnf213;Casp3;Bpgm;Casp7;Ifi27;Psme2;Rnf31;Ly6e;Cmtr1;Tapbp;Tor1b;Trim26;Mthfd2;Slc25a28;Ripk1;Psma2
43	prerank	Protein Secretion	0.2216951127676127	0.7759364123245033	0.871536523929471	0.9645524203008853	1.0	9/85	11.32%	Cd63;Copb2;Vamp7;Cope;Vamp3;Ap2s1;Ergic3;Rer1;Tmx1
44	prerank	Allograft Rejection	0.23999552665871182	0.7643178683577514	0.8465829846582985	0.9564574813064844	1.0	9/51	14.75%	Nme1;Rps9;Rpl39;Csk;Rps19;Eif3d;Degs1;Flna;Eif5a
45	prerank	KRAS Signaling Dn	0.22613743228164682	0.7504661223471343	0.8862433862433863	0.9500602615677779	1.0	7/61	10.85%	Celsr2;Kcnmb1;Arhgdig;Entpd7;Chst2;Kcnd1;Sncb
46	prerank	IL-6/JAK/STAT3 Signaling	0.2691815278013144	0.7328446756427207	0.8408736349453978	0.9478456489519373	1.0	11/23	37.58%	Jun;Hax1;Tnfrsf21;Acvr1b;Ifngr1;Ptpn11;Grb2;Stat2;Csf2ra;Ptpn1;Ptpn2
47	prerank	Interferon Alpha Response	0.2679035902985367	0.7317911311561915	0.8115501519756839	0.9259474910014821	1.0	7/23	23.06%	Ifi27;Psme2;Rnf31;Ly6e;Cmtr1;Trim26;Slc25a28
48	prerank	UV Response Dn	0.1840611345380614	0.6682328764160463	0.9852034525277436	0.9571776413296633	1.0	19/106	21.77%	Pik3cd;Plpp3;Cited2;Smad3;Slc7a1;Bdnf;Synj2;Mta1;Cdkn1b;Anxa2;Col11a1;Tgfbr3;Dbp;Ldlr;Nek7;Smad7;Abcc1;Pparg;Pias3
49	prerank	Mitotic Spindle	-0.13654734956699302	-0.6225645742263682	1.0	1.0	1.0	47/143	31.64%	Smc4;Mid1;Epb41l2;Alms1;Dock4;Arl8a;Dlg1;Stk38l;Nck2;Rasa1;Cdc42bpa;Tuba4a;Cd2ap;Kif1b;Wasf1;Clip2;Rapgef6;Nf1;Ssh2;Als2;Hook3;Ccdc88a;Pcgf5;Clip1;Wasl;Cdk5rap2;Rock1;Ckap5;Numa1;Vcl;Rasa2;Cttn;Tubgcp5;Fgd4;Pcnt;Incenp;Bin1;Sorbs2;Pafah1b1;Rictor;Fscn1;Cntrl;Rapgef5;Kif5b;Pcm1;Tiam1;Tbcd
50	prerank	TGF-beta Signaling	-0.17788089584593306	-0.6052933201645828	0.9689655172413794	1.0	1.0	5/37	13.38%	Bcar3;Fnta;Cdk9;Hdac1;Klf10
51	prerank	Wnt-beta Catenin Signaling	-0.19113300492610838	-0.5890794535568823	0.9709302325581395	0.9900130975769482	1.0	23/23	80.93%	Hdac2;Ncstn;Gnai1;Cul1;Nkd1;Axin1;Wnt5b;Numb;Ncor2;Rbpj;Dvl2;Ptch1;Adam17;Ppard;Skp2;Maml1;Hdac11;Csnk1e;Ctnnb1;Axin2;Psen2;Jag2;Hdac5