RGC-ADOA/output/08_replication/module_score_comparison.csv

1	group	geneset	n_WT	n_V291D	median_WT	median_V291D	delta	wilcoxon_p_exploratory	per_sample_median
2	RGC_highETC(~RGC-2)	ETC_WP295	21	658	-0.1946	-0.1777	0.0169	8.91e-01	Opa1V291D_S1:-0.181; Opa1V291D_S2:-0.175; WT:-0.195
3	RGC_highETC(~RGC-2)	CI_biogenesis_RE	21	658	-0.1199	-0.1065	0.0135	4.31e-01	Opa1V291D_S1:-0.105; Opa1V291D_S2:-0.107; WT:-0.120
4	RGC_highETC(~RGC-2)	Glycolysis_WP157	21	658	0.1865	0.0645	-0.122	1.01e-02	Opa1V291D_S1:0.049; Opa1V291D_S2:0.085; WT:0.187
5	RGC_highETC(~RGC-2)	Ribosomal_WP163	21	658	0.0607	0.0574	-0.0033	8.51e-01	Opa1V291D_S1:0.067; Opa1V291D_S2:0.047; WT:0.061
6	RGC_highETC(~RGC-2)	Mitophagy_Autophagy	21	658	0.0283	-0.0259	-0.0542	3.48e-02	Opa1V291D_S1:-0.036; Opa1V291D_S2:-0.022; WT:0.028
7	RGC_lowETC(~RGC-1)	ETC_WP295	48	284	-0.3585	-0.306	0.0524	7.51e-09	Opa1V291D_S1:-0.298; Opa1V291D_S2:-0.310; WT:-0.358
8	RGC_lowETC(~RGC-1)	CI_biogenesis_RE	48	284	-0.2539	-0.2048	0.0491	3.12e-05	Opa1V291D_S1:-0.200; Opa1V291D_S2:-0.213; WT:-0.254
9	RGC_lowETC(~RGC-1)	Glycolysis_WP157	48	284	-0.1084	0.0418	0.1502	4.71e-09	Opa1V291D_S1:0.005; Opa1V291D_S2:0.073; WT:-0.108
10	RGC_lowETC(~RGC-1)	Ribosomal_WP163	48	284	-0.0173	0.0344	0.0517	1.22e-12	Opa1V291D_S1:0.039; Opa1V291D_S2:0.025; WT:-0.017
11	RGC_lowETC(~RGC-1)	Mitophagy_Autophagy	48	284	-0.0804	-0.0501	0.0303	2.11e-01	Opa1V291D_S1:-0.054; Opa1V291D_S2:-0.048; WT:-0.080
12	Muller	ETC_WP295	183	2389	-0.1572	-0.0374	0.1198	9.40e-18	Opa1V291D_S1:-0.030; Opa1V291D_S2:-0.040; WT:-0.157
13	Muller	CI_biogenesis_RE	183	2389	-0.12	-0.0401	0.0799	1.44e-11	Opa1V291D_S1:-0.027; Opa1V291D_S2:-0.048; WT:-0.120
14	Muller	Glycolysis_WP157	183	2389	-0.027	0.0957	0.1227	2.37e-08	Opa1V291D_S1:0.105; Opa1V291D_S2:0.085; WT:-0.027
15	Muller	Ribosomal_WP163	183	2389	0.052	0.1099	0.0579	1.85e-18	Opa1V291D_S1:0.127; Opa1V291D_S2:0.097; WT:0.052
16	Muller	Mitophagy_Autophagy	183	2389	0.0031	0.0006	-0.0025	5.19e-01	Opa1V291D_S1:-0.002; Opa1V291D_S2:0.004; WT:0.003
17	Rod	ETC_WP295	1773	7866	0.2393	0.2202	-0.0191	4.65e-05	Opa1V291D_S1:0.247; Opa1V291D_S2:0.175; WT:0.239
18	Rod	CI_biogenesis_RE	1773	7866	0.1843	0.1666	-0.0177	3.52e-01	Opa1V291D_S1:0.192; Opa1V291D_S2:0.133; WT:0.184
19	Rod	Glycolysis_WP157	1773	7866	0.6418	0.5654	-0.0764	8.04e-08	Opa1V291D_S1:0.584; Opa1V291D_S2:0.541; WT:0.642
20	Rod	Ribosomal_WP163	1773	7866	0.3027	0.2896	-0.0131	3.33e-06	Opa1V291D_S1:0.314; Opa1V291D_S2:0.236; WT:0.303
21	Rod	Mitophagy_Autophagy	1773	7866	-0.0343	-0.0451	-0.0108	2.65e-04	Opa1V291D_S1:-0.036; Opa1V291D_S2:-0.049; WT:-0.034
22	Cone	ETC_WP295	99	1208	-0.1267	-0.0106	0.1161	1.23e-18	Opa1V291D_S1:-0.009; Opa1V291D_S2:-0.012; WT:-0.127
23	Cone	CI_biogenesis_RE	99	1208	-0.0917	-0.0038	0.0879	3.90e-10	Opa1V291D_S1:0.003; Opa1V291D_S2:-0.013; WT:-0.092
24	Cone	Glycolysis_WP157	99	1208	0.0502	0.2017	0.1515	9.06e-10	Opa1V291D_S1:0.195; Opa1V291D_S2:0.218; WT:0.050
25	Cone	Ribosomal_WP163	99	1208	0.0557	0.1371	0.0814	2.13e-30	Opa1V291D_S1:0.149; Opa1V291D_S2:0.122; WT:0.056
26	Cone	Mitophagy_Autophagy	99	1208	-0.0822	-0.0601	0.0221	2.56e-02	Opa1V291D_S1:-0.038; Opa1V291D_S2:-0.075; WT:-0.082
27	Bipolar	ETC_WP295	106	1426	-0.1576	-0.0933	0.0643	5.37e-06	Opa1V291D_S1:-0.095; Opa1V291D_S2:-0.091; WT:-0.158
28	Bipolar	CI_biogenesis_RE	106	1426	-0.1219	-0.067	0.0548	4.32e-05	Opa1V291D_S1:-0.079; Opa1V291D_S2:-0.062; WT:-0.122
29	Bipolar	Glycolysis_WP157	106	1426	0.0026	0.0638	0.0611	5.00e-03	Opa1V291D_S1:0.062; Opa1V291D_S2:0.066; WT:0.003
30	Bipolar	Ribosomal_WP163	106	1426	0.0395	0.0986	0.059	5.73e-11	Opa1V291D_S1:0.111; Opa1V291D_S2:0.092; WT:0.040
31	Bipolar	Mitophagy_Autophagy	106	1426	-0.0443	-0.0391	0.0052	8.30e-01	Opa1V291D_S1:-0.020; Opa1V291D_S2:-0.055; WT:-0.044
32	Amacrine	ETC_WP295	184	2273	-0.3016	-0.178	0.1236	4.02e-39	Opa1V291D_S1:-0.176; Opa1V291D_S2:-0.180; WT:-0.302
33	Amacrine	CI_biogenesis_RE	184	2273	-0.2142	-0.116	0.0982	1.72e-31	Opa1V291D_S1:-0.112; Opa1V291D_S2:-0.121; WT:-0.214
34	Amacrine	Glycolysis_WP157	184	2273	-0.0855	0.0529	0.1385	2.04e-19	Opa1V291D_S1:0.041; Opa1V291D_S2:0.062; WT:-0.086
35	Amacrine	Ribosomal_WP163	184	2273	0.0038	0.0745	0.0707	3.44e-44	Opa1V291D_S1:0.087; Opa1V291D_S2:0.066; WT:0.004
36	Amacrine	Mitophagy_Autophagy	184	2273	-0.0772	-0.0386	0.0386	3.31e-02	Opa1V291D_S1:-0.045; Opa1V291D_S2:-0.034; WT:-0.077